{"id":"https://openalex.org/W342851802","doi":"https://doi.org/10.21236/ada554154","title":"Systematic Investigation of Key Survival and Growth Pathways in Breast Cancer","display_name":"Systematic Investigation of Key Survival and Growth Pathways in Breast Cancer","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W342851802","doi":"https://doi.org/10.21236/ada554154","mag":"342851802"},"language":"en","primary_location":{"id":"doi:10.21236/ada554154","doi":"https://doi.org/10.21236/ada554154","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada554154","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100365539","display_name":"Junjie Chen","orcid":"https://orcid.org/0000-0002-1493-2189","observed_orcids":["https://orcid.org/0000-0002-1493-2189"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Junjie Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100365539"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.9279999732971191},{"id":"https://openalex.org/keywords/wwp2","display_name":"WWP2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pten-degradation","display_name":"PTEN degradation","score":0.968999981880188},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.7950000166893005},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9890000224113464},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.6815487742424011},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6192787885665894},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4691319167613983},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40441465377807617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38364356756210327},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3800138235092163},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3436626195907593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3275126814842224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2907983362674713},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09684610366821289}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada554154","doi":"https://doi.org/10.21236/ada554154","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada554154","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2792200045","https://openalex.org/W7010231931","https://openalex.org/W4393992806","https://openalex.org/W4413161061","https://openalex.org/W7133034705","https://openalex.org/W7098469412","https://openalex.org/W2092696994","https://openalex.org/W2278129394","https://openalex.org/W3025483560","https://openalex.org/W4392871861"],"abstract_inverted_index":{"Abstract":[0],":":[1],"We":[2,18],"are":[3],"performing":[4],"proteomic":[5],"studies":[6,75],"to":[7],"identify":[8],"new":[9,21],"regulators":[10,22],"involved":[11],"in":[12,23,83],"the":[13,45,78],"RTK/PI3K/AKT":[14],"and":[15,33,39,57,72,87],"Hippo/YAP":[16],"pathways.":[17],"discovered":[19],"several":[20],"these":[24,71,81],"pathways,":[25],"including":[26],"WWP2,":[27],"which":[28,35],"targets":[29],"PTEN":[30],"for":[31],"degradation,":[32],"AMOTL3,":[34],"associates":[36],"with":[37],"YAP1":[38,42],"negatively":[40],"regulates":[41],"activity.":[43],"In":[44],"pass":[46],"funding":[47],"period,":[48],"we":[49],"also":[50],"uncovered":[51],"MEMO1":[52,60],"as":[53],"an":[54],"IRS1-interacting":[55],"protein":[56],"showed":[58],"that":[59,70],"promotes":[61],"epithelial-to-mesenchymal":[62],"transition":[63],"via":[64],"regulating":[65],"IRS1/Snail..":[66],"It":[67],"is":[68],"likely":[69],"other":[73],"ongoing":[74],"will":[76],"reveal":[77],"roles":[79],"of":[80],"interactions":[82],"breast":[84],"cancer":[85],"development":[86],"treatment.":[88]},"counts_by_year":[],"updated_date":"2026-03-25T13:04:00.132906","created_date":"2016-06-24T00:00:00"}
