{"id":"https://openalex.org/W34267955","doi":null,"title":"Effects of recombinant human leptin treatment as an adjunct of moderate energy restriction on body weight, resting energy expenditure and energy intake in obese humans.","display_name":"Effects of recombinant human leptin treatment as an adjunct of moderate energy restriction on body weight, resting energy expenditure and energy intake in obese humans.","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W34267955","mag":"34267955","pmid":"https://pubmed.ncbi.nlm.nih.gov/12846450"},"language":"en","primary_location":{"id":"pmid:12846450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12846450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, nutrition & metabolism","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091572603","display_name":"Anne J. Fogteloo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A J Fogteloo","raw_affiliation_strings":["Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. a.j.fogteloo@lumc.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. a.j.fogteloo@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042579611","display_name":"Hanno Pijl","orcid":"https://orcid.org/0000-0002-3076-1551","observed_orcids":["https://orcid.org/0000-0002-3076-1551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Pijl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035283138","display_name":"Michael A. Fr\u00f6lich","orcid":"https://orcid.org/0000-0001-5779-1331","observed_orcids":["https://orcid.org/0000-0001-5779-1331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fr\u00f6lich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111881318","display_name":"Mark A. Mccamish","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M McCamish","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111750630","display_name":"Arend Edo Meinders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Meinders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3618,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.77429806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"2","first_page":"109","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-human-leptin","display_name":"recombinant human leptin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9670000076293945},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.8550000190734863},{"id":"https://openalex.org/keywords/resting-energy-expenditure","display_name":"resting energy expenditure","score":0.9980000257492065},{"id":"https://openalex.org/keywords/energy-intake","display_name":"energy intake","score":0.996999979019165},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.5149999856948853},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.6370000243186951},{"id":"https://openalex.org/keywords/metabolic-adaptation","display_name":"metabolic adaptation","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.7413471937179565},{"id":"https://openalex.org/C139566807","wikidata":"https://www.wikidata.org/wiki/Q25324083","display_name":"Resting energy expenditure","level":3,"score":0.7378329634666443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7111610174179077},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.702247142791748},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.696237325668335},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6934875249862671},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6892837285995483},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5679062008857727},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.5508522987365723},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5280992388725281},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.4649355113506317},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002153","descriptor_name":"Calorimetry, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004038","descriptor_name":"Diet, Reducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12846450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12846450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, nutrition & metabolism","raw_type":"Clinical Trial"},{"id":"mag:34267955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12846450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993775589","https://openalex.org/W2020984967","https://openalex.org/W2116843182","https://openalex.org/W3091805549","https://openalex.org/W2138521641","https://openalex.org/W2065738278","https://openalex.org/W2129328075","https://openalex.org/W2122571005","https://openalex.org/W2021932374","https://openalex.org/W1950350017"],"abstract_inverted_index":{"We":[0,91],"explored":[1],"the":[2,22,42,136,146,173,203],"effects":[3,43,120],"of":[4,12,24,29,44,47,101,121,138,148,175,190],"recombinant":[5],"human":[6],"leptin":[7],"(rL)":[8],"as":[9,27,187],"an":[10,188],"adjunct":[11,189],"mild":[13],"energy":[14,63,67,125,139,143,149,191],"restriction":[15],"(2092":[16],"kJ/day":[17],"less":[18],"than":[19],"needed)":[20],"in":[21,93,157,163,178,181],"treatment":[23,123],"obese":[25,179],"humans":[26,180],"part":[28],"a":[30,35,99,182],"larger":[31],"multicentre":[32],"trial.":[33],"In":[34],"double":[36],"blind,":[37],"randomised,":[38],"placebo":[39],"(P)-controlled":[40],"design,":[41],"10":[45],"mg":[46],"rL":[48,98,122,132,169,199],"once":[49],"daily":[50,53],"vs":[51],"twice":[52],"(rL":[54,78,82,109,113],"OD/BID,":[55],"by":[56,198],"s.c.":[57],"injection)":[58],"upon":[59,124],"body":[60,102,176],"weight,":[61],"resting":[62],"expenditure":[64,140],"(REE)":[65],"and":[66,80,205],"intake":[68,126,150],"were":[69,129],"compared.":[70],"The":[71],"study":[72],"groups":[73,95],"comprised":[74],"9":[75],"(P),":[76,106],"15":[77],"OD)":[79],"6":[81],"BID)":[83],"healthy":[84],"subjects":[85,159,164],"(body":[86],"mass":[87],"index":[88],"27.5-35":[89],"kg/m2).":[90],"observed":[92],"both":[94],"treated":[96,165],"with":[97,142,166],"decline":[100,137],"weight.":[103],"[2.8+/-1.1":[104],"kg":[105,108,112],"5.2+/-0.9":[107],"OD),":[110],"7.9+/-1.4":[111],"BID),":[114],"p":[115],"<":[116],"0.035].":[117],"No":[118],"significant":[119],"or":[127],"REE":[128],"observed.":[130],"However,":[131],"tended":[133],"to":[134,151,154,171,201],"reduce":[135],"associated":[141],"restriction,":[144],"whereas":[145],"tendency":[147],"increase":[152],"back":[153],"baseline":[155],"levels":[156],"placebo-treated":[158],"was":[160],"largely":[161],"prevented":[162],"rL.":[167],"Thus,":[168],"appears":[170],"enhance":[172],"loss":[174,211],"weight":[177,210],"dose-dependent":[183],"fashion":[184],"if":[185],"prescribed":[186],"restriction.":[192],"This":[193],"effect":[194],"might":[195],"be":[196],"mediated":[197],"ability":[200],"counteract":[202],"behavioural":[204],"metabolic":[206],"adaptations":[207],"that":[208],"accompany":[209],"attempts.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}