{"id":"https://openalex.org/W3425171","doi":null,"title":"Photodynamic effects on choroidal neovascularization and physiological choroid.","display_name":"Photodynamic effects on choroidal neovascularization and physiological choroid.","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W3425171","mag":"3425171","pmid":"https://pubmed.ncbi.nlm.nih.gov/11867605"},"language":"en","primary_location":{"id":"pmid:11867605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053563726","display_name":"Ursula Margarethe Schmidt-Erfurth","orcid":"https://orcid.org/0000-0002-7788-7311","observed_orcids":["https://orcid.org/0000-0002-7788-7311"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ursula Schmidt-Erfurth","raw_affiliation_strings":["Eye Hospital, University of L\u00fcbeck, Ratzeburger Allee 160, D-23538 L\u00fcbeck, Germany. uschmidterfurth@ophtha.mu-luebeck.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eye Hospital, University of L\u00fcbeck, Ratzeburger Allee 160, D-23538 L\u00fcbeck, Germany. uschmidterfurth@ophtha.mu-luebeck.de","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113827770","display_name":"Stephan Michels","orcid":"https://orcid.org/0000-0002-3146-7805","observed_orcids":["https://orcid.org/0000-0002-3146-7805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Michels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083263034","display_name":"IRENE A. BARBAZETTO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irene Barbazetto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058311677","display_name":"Horst Laqua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Horst Laqua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.4467,"has_fulltext":false,"cited_by_count":232,"citation_normalized_percentile":{"value":0.99627117,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"43","issue":"3","first_page":"830","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choroidal-neovascularization","display_name":"choroidal neovascularization","score":0.9129999876022339},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9700000286102295},{"id":"https://openalex.org/keywords/verteporfin","display_name":"verteporfin","score":0.996999979019165},{"id":"https://openalex.org/keywords/indocyanine-green-angiography","display_name":"indocyanine green angiography","score":0.8949999809265137},{"id":"https://openalex.org/keywords/choroidal-circulation","display_name":"choroidal blood flow","score":0.7820000052452087},{"id":"https://openalex.org/keywords/lesion-recurrence","display_name":"lesion recurrence","score":0.5519999861717224},{"id":"https://openalex.org/keywords/subfoveal-cnv","display_name":"subfoveal CNV","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2776694393","wikidata":"https://www.wikidata.org/wiki/Q271762","display_name":"Choroid","level":3,"score":0.907279908657074},{"id":"https://openalex.org/C2781359195","wikidata":"https://www.wikidata.org/wiki/Q5105209","display_name":"Choroidal neovascularization","level":3,"score":0.8730019330978394},{"id":"https://openalex.org/C2781148688","wikidata":"https://www.wikidata.org/wiki/Q782318","display_name":"Verteporfin","level":4,"score":0.826073408126831},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6989511251449585},{"id":"https://openalex.org/C2781065829","wikidata":"https://www.wikidata.org/wiki/Q905662","display_name":"Indocyanine green","level":2,"score":0.6967580318450928},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.591865599155426},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.5711992979049683},{"id":"https://openalex.org/C2776599846","wikidata":"https://www.wikidata.org/wiki/Q5145979","display_name":"Collateral circulation","level":2,"score":0.5131343007087708},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.4959889352321625},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.477045476436615},{"id":"https://openalex.org/C2777858674","wikidata":"https://www.wikidata.org/wiki/Q1248007","display_name":"Vascular occlusion","level":2,"score":0.41673290729522705},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.34163594245910645},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3343495726585388},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3174595534801483},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.24784642457962036},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.17171719670295715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08741390705108643},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.06813168525695801},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077362","descriptor_name":"Verteporfin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D002829","descriptor_name":"Choroid","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007208","descriptor_name":"Indocyanine Green","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014054","descriptor_name":"Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11867605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Clinical Trial"},{"id":"mag:3425171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11867605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1911994","https://openalex.org/W17299339","https://openalex.org/W17858553","https://openalex.org/W45954904","https://openalex.org/W186636329","https://openalex.org/W1489281785","https://openalex.org/W1505548606","https://openalex.org/W1539344594","https://openalex.org/W1580014443","https://openalex.org/W1601975653","https://openalex.org/W1974962502","https://openalex.org/W2025450244","https://openalex.org/W2025634016","https://openalex.org/W2053911275","https://openalex.org/W2057537343","https://openalex.org/W2063634158","https://openalex.org/W2079934342","https://openalex.org/W2106672769","https://openalex.org/W2114900908","https://openalex.org/W2124199139","https://openalex.org/W2133251726","https://openalex.org/W2136522209","https://openalex.org/W2169251966","https://openalex.org/W2442102764"],"related_works":["https://openalex.org/W1966176990","https://openalex.org/W2106672769","https://openalex.org/W2009175584","https://openalex.org/W7027998179","https://openalex.org/W2079564763","https://openalex.org/W2160220292","https://openalex.org/W7217787283","https://openalex.org/W29036150","https://openalex.org/W2387427029","https://openalex.org/W2354542764"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,73,84,87,140,152,189,208,217,222],"effect":[4],"of":[5,14,69,86,133,139,205],"photodynamic":[6],"therapy":[7],"(PDT)":[8],"on":[9,83],"perfusion":[10,215],"and":[11,18,36,57,60,64,81,89,99,113,128,183,211,231],"vascular":[12],"integrity":[13],"choroidal":[15,141,190,233],"neovascularization":[16],"(CNV)":[17],"collateral":[19,90],"physiological":[20],"choroid.":[21,224],"METHODS:":[22],"In":[23],"a":[24,43,65,111,117,212],"prospective":[25],"clinical":[26],"trial,":[27],"patients":[28],"with":[29,34,48],"subfoveal":[30],"CNV":[31,88,121,206],"were":[32,78,104,123],"treated":[33],"PDT":[35,202],"verteporfin.":[37],"Indocyanine":[38],"green":[39],"angiography":[40],"(ICG-A),":[41],"using":[42],"confocal":[44],"laser":[45],"scanning":[46],"system":[47],"tomographic":[49],"sections,":[50],"was":[51,145,173],"performed":[52],"continuously":[53],"1":[54],"week":[55],"before":[56],"1,":[58],"4,":[59],"12":[61,114,178],"weeks":[62,179],"after":[63,72,180,201],"mean":[66],"long-term":[67,196],"follow-up":[68],"16.5":[70],"months":[71],"final":[74],"PDT.":[75,185],"Vascular":[76],"changes":[77,187],"localized":[79],"tomographically":[80],"quantified":[82],"level":[85],"choroid":[91,164],"according":[92],"to":[93,166,177],"early":[94],"lesion":[95],"size,":[96],"late":[97,129],"hyperfluorescence,":[98],"persistence":[100,204],"or":[101],"recurrence.":[102],"Data":[103],"analyzed":[105],"separately":[106],"from":[107,151],"38":[108],"eyes":[109,115],"in":[110,116,126,188,214,229],"single-":[112],"multiple-treatment":[118],"regimen.":[119],"RESULTS:":[120],"lesions":[122,134],"significantly":[124],"reduced":[125],"size":[127],"hyperfluorescence.":[130],"However,":[131],"54%":[132],"primarily":[135],"demonstrated":[136],"persistence,":[137],"typically":[138],"feeding":[142,153],"complex,":[143],"which":[144],"only":[146],"detectable":[147],"by":[148],"ICG-A.":[149],"Regrowth":[150],"vessel":[154,210],"occurred":[155],"regularly,":[156],"but":[157],"did":[158],"not":[159],"reach":[160],"baseline":[161],"dimensions.":[162],"Collateral":[163],"exposed":[165],"photoactivation":[167],"exhibited":[168],"choriocapillary":[169],"occlusion.":[170],"Progressive":[171],"recanalization":[172],"documented":[174],"within":[175,216],"4":[176],"both":[181],"single":[182],"multiple":[184],"Residual":[186],"filling":[191],"pattern":[192],"often":[193],"persisted":[194],"during":[195],"follow-up.":[197],"CONCLUSIONS:":[198],"Tomographic":[199],"ICG-A":[200],"reveals":[203],"and/or":[207],"feeder":[209],"reduction":[213],"entire":[218],"photosensitized":[219],"area,":[220],"including":[221],"surrounding":[223],"Repair":[225],"mechanisms":[226],"occur":[227],"slowly":[228],"neovascular":[230],"normal":[232],"structures.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}