{"id":"https://openalex.org/W342333256","doi":"https://doi.org/10.4049/jimmunol.186.supp.48.3","title":"The role of amyloid precursor-like protein 2 in Ewing\u2019s sarcoma resistance to immunity (48.3)","display_name":"The role of amyloid precursor-like protein 2 in Ewing\u2019s sarcoma resistance to immunity (48.3)","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W342333256","doi":"https://doi.org/10.4049/jimmunol.186.supp.48.3","mag":"342333256"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.186.supp.48.3","doi":"https://doi.org/10.4049/jimmunol.186.supp.48.3","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.48.3","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059889590","display_name":"Haley L. Peters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley Peters","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100638595","display_name":"Xiaojian Wang","orcid":"https://orcid.org/0000-0001-8232-0558","observed_orcids":["https://orcid.org/0000-0001-8232-0558"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojian Wang","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075164788","display_name":"Tara M. Nordgren","orcid":"https://orcid.org/0000-0001-6398-8528","observed_orcids":["https://orcid.org/0000-0001-6398-8528"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara Nordgren","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006751323","display_name":"Christine E Gilling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Gilling","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shantaram Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shantaram Joshi","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395068","display_name":"Yan Yan","orcid":"https://orcid.org/0000-0002-5917-1475","observed_orcids":["https://orcid.org/0000-0002-5917-1475","https://orcid.org/0009-0003-4258-1149"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Yan","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086505077","display_name":"Joyce C. Solheim","orcid":"https://orcid.org/0000-0002-6313-8213","observed_orcids":["https://orcid.org/0000-0002-6313-8213"]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Solheim","raw_affiliation_strings":["University of Nebraska Medical Center , Omaha, NE","1University of Nebraska Medical Center, Omaha, NE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nebraska Medical Center , Omaha, NE","institution_ids":["https://openalex.org/I59130452"]},{"raw_affiliation_string":"1University of Nebraska Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I59130452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"186","issue":"1_Supplement","first_page":"48.3","last_page":"48.3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.018699999898672104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplp2","display_name":"APLP2","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ewing-sarcoma","display_name":"Ewing sarcoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6959999799728394},{"id":"https://openalex.org/keywords/lymphokine-activated-killer-cells","display_name":"lymphokine-activated killer cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.847000002861023},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9390000104904175},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-immune-recognition","display_name":"tumor immune recognition","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6555087566375732},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5578975081443787},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5108553767204285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5095153450965881},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47330108284950256},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4223489761352539},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4173693358898163},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2386557161808014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20321926474571228},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05822846293449402}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.186.supp.48.3","doi":"https://doi.org/10.4049/jimmunol.186.supp.48.3","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.186.supp.48.3","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134374536","https://openalex.org/W1989774519","https://openalex.org/W2530104270","https://openalex.org/W2781923253","https://openalex.org/W1638124197","https://openalex.org/W2125354405","https://openalex.org/W1977583182","https://openalex.org/W2012731036","https://openalex.org/W1543343845","https://openalex.org/W2170153138"],"abstract_inverted_index":{"Abstract":[0],"Metastasized":[1],"Ewing\u2019s":[2,20,38,59,76,141,171,211],"sarcoma,":[3],"a":[4,11,122,140,170],"childhood":[5],"cancer":[6],"of":[7,45,71,90,139,179,187,205,210],"the":[8,30,69,184],"bone,":[9],"has":[10],"dismal":[12],"20-30%":[13],"5-year":[14],"survival":[15],"rate,":[16],"despite":[17],"multi-modal":[18],"therapy.":[19],"sarcoma":[21,39,60,77,142,172,212],"cells":[22,61,78,86,99,120,192],"have":[23,34,121],"been":[24],"shown":[25],"to":[26,53,82,102,104,125,130,135,165,183,189],"escape":[27],"elimination":[28],"by":[29,109,157],"immune":[31,64,110,208],"system.":[32],"We":[33,51],"found":[35,164],"that":[36,62,79,94,118],"several":[37],"cell":[40,106,143,173],"lines":[41],"express":[42],"substantial":[43],"levels":[44,89],"amyloid":[46],"precursor-like":[47],"protein":[48],"2":[49],"(APLP2).":[50],"sought":[52],"characterize":[54],"cellular":[55],"changes":[56],"associated":[57],"with":[58,66,113,145],"avoid":[63],"recognition,":[65],"emphasis":[67],"on":[68],"function":[70],"APLP2":[72,91,96,146,167],"in":[73,97,127,169,175],"this":[74,114],"process.":[75],"survived":[80],"exposure":[81,134],"lymphokine-activated":[83],"killer":[84],"(LAK)":[85],"exhibited":[87],"higher":[88],"expression,":[92],"suggesting":[93],"elevated":[95],"these":[98,200],"may":[100,181],"contribute":[101,182],"resistance":[103],"apoptotic":[105],"death":[107],"mediated":[108],"effectors.":[111],"Consistent":[112],"theory,":[115],"we":[116],"demonstrated":[117],"LAK-challenged":[119],"reduced":[123,147],"tendency":[124],"arrest":[126,150],"G2/M":[128,149],"and":[129,151,160],"undergo":[131],"apoptosis":[132],"following":[133],"gamma-irradiation.":[136],"Transient":[137],"transfection":[138],"line":[144,174],"irradiation-mediated":[148],"apoptosis.":[152],"IFN-gamma":[153,180,188],"(a":[154],"cytokine":[155],"produced":[156],"LAK,":[158],"NK":[159],"T":[161],"cells)":[162],"was":[163],"up-regulate":[166],"production":[168],"vitro.":[176],"This":[177],"effect":[178],"known":[185],"ability":[186],"protect":[190],"tumor":[191],"from":[193,199],"LAK-mediated":[194],"lysis.":[195],"Overall,":[196],"our":[197,203],"findings":[198],"studies":[201],"increase":[202],"understanding":[204],"mechanisms":[206],"regulating":[207],"recognition":[209],"cells.":[213]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}