{"id":"https://openalex.org/W342210867","doi":null,"title":"Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia","display_name":"Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia","publication_year":2015,"publication_date":"2015-02-11","ids":{"openalex":"https://openalex.org/W342210867","mag":"342210867"},"language":"en","primary_location":{"id":"mag:342210867","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/25834907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088797237","display_name":"David B. Sykes","orcid":"https://orcid.org/0000-0002-9788-0221","observed_orcids":["https://orcid.org/0000-0002-9788-0221"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Sykes","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0002-9788-0221","affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111761036","display_name":"Mark K. Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark K. Haynes","raw_affiliation_strings":["University of New Mexico, albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014727189","display_name":"Anna Waller","orcid":"https://orcid.org/0000-0003-3676-2501","observed_orcids":["https://orcid.org/0000-0003-3676-2501"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Waller","raw_affiliation_strings":["University of New Mexico, albuquerque, NM"],"raw_orcid":"https://orcid.org/0000-0003-3676-2501","affiliations":[{"raw_affiliation_string":"University of New Mexico, albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035319973","display_name":"Matthew J. Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Garcia","raw_affiliation_strings":["University of New Mexico, albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064097191","display_name":"Oleg Ursu","orcid":"https://orcid.org/0000-0003-0596-8339","observed_orcids":["https://orcid.org/0000-0003-0596-8339"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleg Ursu","raw_affiliation_strings":["University of New Mexico, albuquerque, NM"],"raw_orcid":"https://orcid.org/0000-0003-0596-8339","affiliations":[{"raw_affiliation_string":"University of New Mexico, albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035872691","display_name":"Kristine Gouveia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristine Gouveia","raw_affiliation_strings":["University of New Mexico, albuquerque, NM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of New Mexico, albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028187863","display_name":"Larry A. Sklar","orcid":"https://orcid.org/0000-0002-8196-5060","observed_orcids":["https://orcid.org/0000-0002-8196-5060"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry A. Sklar","raw_affiliation_strings":["University of New Mexico, albuquerque, NM"],"raw_orcid":"https://orcid.org/0000-0002-8196-5060","affiliations":[{"raw_affiliation_string":"University of New Mexico, albuquerque, NM","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023645110","display_name":"Timothy A. Lewis","orcid":"https://orcid.org/0000-0001-9748-9575","observed_orcids":["https://orcid.org/0000-0001-9748-9575"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Lewis","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA 02142"],"raw_orcid":"https://orcid.org/0000-0001-9748-9575","affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA 02142","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086104008","display_name":"Sivaraman Dandapani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sivaraman Dandapani","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA 02142","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113212935","display_name":"Benito Mu\u00f1oz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benito Mu\u00f1oz","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA 02142","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Scadden","raw_affiliation_strings":["Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA"],"raw_orcid":"https://orcid.org/0000-0001-9821-7133","affiliations":[{"raw_affiliation_string":"Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112197978","display_name":"Michelle A. J. Palmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Palmer","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA 02142"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA 02142","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035618234","display_name":"Stuart L. Schreiber","orcid":"https://orcid.org/0000-0003-1922-7558","observed_orcids":["https://orcid.org/0000-0003-1922-7558"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart L. Schreiber","raw_affiliation_strings":["The Broad Institute Probe Development Center, Cambridge, MA 02142"],"raw_orcid":"https://orcid.org/0000-0003-1922-7558","affiliations":[{"raw_affiliation_string":"The Broad Institute Probe Development Center, Cambridge, MA 02142","institution_ids":["https://openalex.org/I107606265"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2611,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59576088,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/differentiation-arrest","display_name":"differentiation arrest","score":0.7509999871253967},{"id":"https://openalex.org/keywords/hoxa9","display_name":"HOXA9","score":0.8809999823570251},{"id":"https://openalex.org/keywords/differentiation-therapy","display_name":"differentiation therapy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/small-molecule-screening","display_name":"small molecule screening","score":0.5189999938011169},{"id":"https://openalex.org/keywords/stereospecificity","display_name":"stereospecificity","score":0.6290000081062317},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.7577680945396423},{"id":"https://openalex.org/C2779982571","wikidata":"https://www.wikidata.org/wiki/Q25098780","display_name":"Differentiation therapy","level":5,"score":0.6107754707336426},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.590112030506134},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5803852677345276},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5497796535491943},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5049989819526672},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4931878447532654},{"id":"https://openalex.org/C204258353","wikidata":"https://www.wikidata.org/wiki/Q7670282","display_name":"THP1 cell line","level":3,"score":0.46350330114364624},{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.44711560010910034},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4277162551879883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40559035539627075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3606427311897278},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3409808874130249},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3350784182548523},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.18039780855178833},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1347057819366455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12106475234031677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10035276412963867},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:342210867","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/25834907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W175241905","https://openalex.org/W2014775266","https://openalex.org/W2113601375"],"related_works":["https://openalex.org/W2973411545","https://openalex.org/W2568611035","https://openalex.org/W2195031314","https://openalex.org/W2126443656","https://openalex.org/W2526797893","https://openalex.org/W2983210117","https://openalex.org/W2811164775","https://openalex.org/W4378417901","https://openalex.org/W3208498531","https://openalex.org/W2553355410"],"abstract_inverted_index":{"Acute":[0],"Myeloid":[1],"Leukemia":[2],"(AML)":[3],"in":[4,35,54,103,138,151,217,295,307,329,344,372,385],"adults":[5],"is":[6,68,281],"a":[7,12,55,81,115,121,310,347,414,443,447],"clinically":[8,415],"devastating":[9],"disease":[10],"with":[11,62,114,250,455],"5-year":[13],"survival":[14],"rate":[15],"of":[16,31,45,51,58,75,86,95,107,118,189,260,279,301,312,317,336,370,401,407,435],"only":[17],"25%.":[18],"We":[19,225,390],"lack":[20],"new":[21,449],"and":[22,27,144,149,163,186,223,242,333,365,381,393,439,450],"effective":[23],"therapies":[24],"for":[25,71,179,291,419,446,453],"AML,":[26,408],"the":[28,43,49,72,92,96,154,190,231,239,293,399,433],"chemotherapy":[29,368,380],"standard":[30,369],"care":[32,371],"remains":[33],"unchanged":[34],"thirty":[36,206,388],"years.":[37,389],"One":[38,188],"success":[39],"story":[40],"has":[41,382],"been":[42],"discovery":[44],"drugs":[46],"that":[47,213,427],"trigger":[48],"differentiation":[50,102,125,270,355,437],"leukemic":[52,363],"blasts":[53],"small":[56,131],"subset":[57],"patients,":[59],"approximately":[60,205],"10%,":[61],"acute":[63,76,87,349,373,420,456],"pro-myelocytic":[64],"leukemia.":[65,422,458],"Differentiation":[66],"therapy":[67,418],"not":[69,383],"available":[70],"remaining":[73],"90%":[74],"myeloid":[77,88,350,374,421,457],"leukemia":[78,274,351,375],"patients.We":[79],"generated":[80],"novel":[82,403],"cell":[83,156,165,219,330,338,404],"line":[84,157,405],"model":[85,406],"leukemia,":[89],"based":[90,182],"on":[91,272,362,377],"potent":[93,235,269,451],"ability":[94],"homeobox":[97],"protein":[98],"HoxA9":[99],"to":[100,198,352,411],"block":[101],"primary":[104,263],"murine":[105,162],"cultures":[106,259],"immature":[108],"myeloblasts.":[109],"These":[110],"cells":[111],"were":[112,135,146,177,214],"engineered":[113],"built-in":[116],"reporter":[117],"differentiation,":[119],"permitting":[120],"high-throughput":[122],"flow-cytometry-based":[123],"phenotypic":[124],"screen":[126],"against":[127,153,258],"more":[128,215,386],"than":[129,387],"330,000":[130],"molecules.":[132],"2,500":[133],"compounds":[134,143,171,212],"retested":[136],"resulting":[137],"twenty-nine":[139],"confirmed":[140],"hits.":[141],"Active":[142],"analogs":[145],"obtained,":[147],"validated,":[148],"tested":[150,343],"dose":[152],"screening":[155],"as":[158,160,230,287,289,357,359],"well":[159,288,358],"other":[161],"human":[164,262],"lines.":[166],"This":[167],"identified":[168,210,413],"twelve":[169],"active":[170,216],"from":[172],"which":[173],"two":[174,191],"distinct":[175],"scaffolds":[176],"chosen":[178,227],"further":[180],"study":[181],"upon":[183],"chemical":[184],"tractability":[185],"availability.":[187],"hits":[192],"demonstrated":[193],"stereospecificity,":[194],"hence":[195],"we":[196,209,409,425],"chose":[197],"explore":[199],"SAR":[200],"about":[201],"this":[202],"lead.":[203],"Of":[204,237],"synthesized":[207],"analogs,":[208],"four":[211],"three":[218],"lines":[220],"(THP-1,":[221],"U937":[222],"ERHOXA9).":[224],"have":[226,412],"compound":[228,241,294],"ML390":[229,245,340,428],"probe":[232],"given":[233],"its":[234,243,268,277,354,360],"activity.":[236],"note,":[238],"lead":[240],"analog":[244],"are":[246,297],"both":[247],"very":[248],"well-tolerated":[249],"limited":[251],"cytotoxicity":[252],"at":[253],"high":[254],"concentrations":[255],"when":[256],"assayed":[257],"normal":[261],"bone":[264],"marrow":[265],"cells.ML390":[266],"exerts":[267],"effect":[271,356,361],"multiple":[273],"models,":[275],"though":[276],"mechanism":[278,434],"action":[280,302],"currently":[282,298],"unknown.":[283],"Target":[284],"identification":[285],"assays":[286],"experiments":[290],"testing":[292],"vivo":[296],"underway.":[299],"Mechanism":[300],"studies":[303,315],"will":[304,341,429,440],"be":[305,342],"performed":[306],"parallel":[308],"using":[309],"combination":[311],"gene":[313],"expression":[314],"(Library":[316],"Integrated":[318],"Network-Based":[319],"Cellular":[320],"Signatures,":[321],"LINCS),":[322],"stable":[323],"isotope":[324],"labeling":[325],"by":[326],"amino":[327],"acids":[328],"culture":[331],"(SILAC),":[332],"next-generation":[334],"sequencing":[335],"compound-resistant":[337],"clones.":[339],"mice":[345],"harboring":[346],"HoxA9-driven":[348],"assess":[353],"progression":[364],"overall":[366],"survival.The":[367],"relies":[376],"traditional":[378],"cytotoxic":[379],"changed":[384],"need":[391],"new,":[392],"less":[394],"toxic,":[395],"therapeutic":[396],"agents.":[397],"In":[398],"context":[400],"our":[402],"hope":[410],"relevant":[416],"pro-differentiation":[417],"If":[423],"successful,":[424],"anticipate":[426],"offer":[430],"insight":[431],"into":[432,442],"overcoming":[436],"arrest,":[438],"translate":[441],"starting":[444],"point":[445],"much-needed":[448],"treatment":[452],"patients":[454]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}
