{"id":"https://openalex.org/W34208533","doi":null,"title":"A review of factors influencing the incidence and severity of plaque-induced gingivitis.","display_name":"A review of factors influencing the incidence and severity of plaque-induced gingivitis.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W34208533","mag":"34208533","pmid":"https://pubmed.ncbi.nlm.nih.gov/23828258"},"language":"en","primary_location":{"id":"pmid:23828258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23828258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva stomatologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054202534","display_name":"Leonardo Trombelli","orcid":"https://orcid.org/0000-0002-1147-2199","observed_orcids":["https://orcid.org/0000-0002-1147-2199"]},"institutions":[{"id":"https://openalex.org/I201324441","display_name":"University of Ferrara","ror":"https://ror.org/041zkgm14","country_code":"IT","type":"education","lineage":["https://openalex.org/I201324441"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L Trombelli","raw_affiliation_strings":["Research Centre for the Study of Periodontal and Peri-implant Diseases University of Ferrara, Ferrara, Italy - leonardo.trombelli@unife.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Centre for the Study of Periodontal and Peri-implant Diseases University of Ferrara, Ferrara, Italy - leonardo.trombelli@unife.it","institution_ids":["https://openalex.org/I201324441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022391843","display_name":"Roberto Fari\u00f1a","orcid":"https://orcid.org/0000-0002-4621-7809","observed_orcids":["https://orcid.org/0000-0002-4621-7809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Farina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0929,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.93780655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"6","first_page":"207","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-induced-gingivitis","display_name":"plaque-induced gingivitis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dental-plaque","display_name":"dental plaque","score":0.8169999718666077},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6779999732971191},{"id":"https://openalex.org/keywords/systemic-factors","display_name":"systemic factors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.5019999742507935},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/periodontal-disease-classification","display_name":"periodontal disease classification","score":0.7549999952316284},{"id":"https://openalex.org/keywords/etiopathogenesis","display_name":"etiopathogenesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2780791200","wikidata":"https://www.wikidata.org/wiki/Q673083","display_name":"Gingivitis","level":2,"score":0.9198815822601318},{"id":"https://openalex.org/C2779914569","wikidata":"https://www.wikidata.org/wiki/Q143504","display_name":"Dental plaque","level":2,"score":0.7398461103439331},{"id":"https://openalex.org/C2909956956","wikidata":"https://www.wikidata.org/wiki/Q673083","display_name":"Gingival inflammation","level":3,"score":0.67470782995224},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6031004786491394},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.5590476989746094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5208942890167236},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.47970980405807495},{"id":"https://openalex.org/C3020564189","wikidata":"https://www.wikidata.org/wiki/Q16963978","display_name":"Host factors","level":3,"score":0.46645087003707886},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.4506731331348419},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.41745051741600037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.316727876663208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25360405445098877},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.17228400707244873},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08033505082130432},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0724833607673645},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003773","descriptor_name":"Dental Plaque","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003773","descriptor_name":"Dental Plaque","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004200","descriptor_name":"Diseases in Twins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004314","descriptor_name":"Down Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005891","descriptor_name":"Gingivitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D005891","descriptor_name":"Gingivitis","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D005891","descriptor_name":"Gingivitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005891","descriptor_name":"Gingivitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005891","descriptor_name":"Gingivitis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:23828258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23828258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Minerva stomatologica","raw_type":"Journal Article"},{"id":"pmh:oai:sfera.unife.it:11392/1888119","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/1888119","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:34208533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23828258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W103575129","https://openalex.org/W1948560807","https://openalex.org/W2136799184"],"related_works":["https://openalex.org/W2900142662","https://openalex.org/W2416458458","https://openalex.org/W2809458634","https://openalex.org/W2137004598","https://openalex.org/W2066543326","https://openalex.org/W2172599898","https://openalex.org/W2075640755","https://openalex.org/W7217560694","https://openalex.org/W4213156967","https://openalex.org/W4211258849"],"abstract_inverted_index":{"An":[0],"individual":[1,58],"variation":[2],"in":[3,28,35,62],"the":[4,9,49,73,90,100,108,111,132,140,145],"gingival":[5,36,50,78,146],"inflammatory":[6,37,147],"response":[7,38,51,148],"to":[8,52,89,94,105,149],"dental":[10,150],"biofilm":[11],"has":[12],"been":[13],"demonstrated.":[14],"This":[15],"variability":[16],"can":[17,80],"be":[18,56,81],"observed":[19],"between":[20],"individuals":[21],"with":[22],"neither":[23],"quantitative":[24],"nor":[25],"qualitative":[26],"differences":[27,34],"plaque":[29,53],"accumulation.":[30],"The":[31,64,97],"reported":[32],"significant":[33],"under":[39],"quantitatively":[40],"and/or":[41],"qualitatively":[42],"almost":[43],"identical":[44],"bacterial":[45],"challenge":[46],"suggest":[47],"that":[48,72],"accumulation":[54],"may":[55],"an":[57],"trait,":[59],"possibly":[60],"genetic":[61],"origin.":[63],"most":[65],"recent":[66],"classification":[67],"of":[68,76,99,113,135,144],"periodontal":[69],"diseases":[70],"acknowledges":[71],"clinical":[74],"expression":[75],"plaque-induced":[77,114,136],"inflammation":[79],"substantially":[82],"modified":[83],"by":[84],"systemic":[85,124],"factors,":[86],"either":[87],"inherent":[88],"host":[91],"or":[92,142],"related":[93],"environmental":[95,122],"influences.":[96],"aim":[98],"present":[101],"literature":[102],"review":[103],"is":[104],"describe":[106],"(i)":[107],"factors":[109,125],"influencing":[110],"development":[112],"gingivitis":[115],"as":[116,118],"well":[117],"(ii)":[119],"those":[120],"metabolic,":[121],"and":[123],"which":[126],"have":[127],"a":[128],"direct":[129],"impact":[130],"on":[131],"etiopathogenetic":[133],"pathway":[134],"gingivitis,":[137],"thus":[138],"altering":[139],"nature":[141],"course":[143],"biofilm.":[151]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}