{"id":"https://openalex.org/W34178795","doi":null,"title":"Defining interactions between assembling HIV-1 virions and host cell plasma membrane proteins","display_name":"Defining interactions between assembling HIV-1 virions and host cell plasma membrane proteins","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W34178795","mag":"34178795"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/100089","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100089","pdf_url":"https://hdl.handle.net/2027.42/100089","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/100089","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068500341","display_name":"Jonathan R. Grover","orcid":"https://orcid.org/0000-0003-2137-600X","observed_orcids":["https://orcid.org/0000-0003-2137-600X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jonathan R. Grover","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068500341"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetherin","display_name":"tetherin","score":0.6679999828338623},{"id":"https://openalex.org/keywords/vpu","display_name":"Vpu","score":0.7680000066757202},{"id":"https://openalex.org/keywords/membrane-curvature","display_name":"membrane curvature","score":0.6769999861717224},{"id":"https://openalex.org/keywords/gag","display_name":"Gag","score":0.7210000157356262},{"id":"https://openalex.org/keywords/escrt-machinery","display_name":"ESCRT machinery","score":0.9860000014305115},{"id":"https://openalex.org/keywords/plasma-membrane-microdomains","display_name":"plasma membrane microdomains","score":0.8389999866485596},{"id":"https://openalex.org/keywords/uropod","display_name":"uropod","score":0.7360000014305115},{"id":"https://openalex.org/keywords/psgl-1","display_name":"PSGL-1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hiv-1-replication","display_name":"HIV-1 replication","score":0.6389999985694885},{"id":"https://openalex.org/keywords/hiv-1-accessory-proteins","display_name":"HIV-1 accessory proteins","score":0.5619999766349792},{"id":"https://openalex.org/keywords/super-resolution-microscopy","display_name":"super-resolution microscopy","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5281657576560974},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5248287320137024},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4874875545501709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4819652736186981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4508506953716278},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.43294256925582886},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41446784138679504},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3492552638053894},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3170662522315979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27453917264938354},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.27255386114120483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20127254724502563},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1422557234764099},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10081171989440918},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/100089","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100089","pdf_url":"https://hdl.handle.net/2027.42/100089","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:34178795","doi":null,"is_oa":false,"landing_page_url":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/100089/jrgrover_1.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/100089","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/100089","pdf_url":"https://hdl.handle.net/2027.42/100089","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5083947398","display_name":"Relationships between HIV-1 assembly and the plasma membrane organization","funder_award_id":"R56AI089282","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7175199518","display_name":"Recruitment of BST-2/tetherin to HIV-1 assembly sites","funder_award_id":"R21AI095022","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W34178795.pdf","grobid_xml":"https://content.openalex.org/works/W34178795.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W138856452","https://openalex.org/W1034217151","https://openalex.org/W1501858161","https://openalex.org/W1571744798","https://openalex.org/W1659719610","https://openalex.org/W1813266103","https://openalex.org/W1898326375","https://openalex.org/W1963508527","https://openalex.org/W1965157736","https://openalex.org/W1966655306","https://openalex.org/W1971421092","https://openalex.org/W1978141733","https://openalex.org/W1980192086","https://openalex.org/W1980798766","https://openalex.org/W1980926787","https://openalex.org/W1982692592","https://openalex.org/W1984237320","https://openalex.org/W1985756888","https://openalex.org/W1987346882","https://openalex.org/W1988278060","https://openalex.org/W1988926833","https://openalex.org/W1990254504","https://openalex.org/W1992858116","https://openalex.org/W1993877052","https://openalex.org/W1994324680","https://openalex.org/W1996835624","https://openalex.org/W1997116306","https://openalex.org/W1999678180","https://openalex.org/W2004469343","https://openalex.org/W2007496937","https://openalex.org/W2010458160","https://openalex.org/W2012065621","https://openalex.org/W2012956482","https://openalex.org/W2015712155","https://openalex.org/W2018869629","https://openalex.org/W2021067210","https://openalex.org/W2023420720","https://openalex.org/W2025830466","https://openalex.org/W2026432118","https://openalex.org/W2029930485","https://openalex.org/W2032204627","https://openalex.org/W2032660967","https://openalex.org/W2033320393","https://openalex.org/W2034360565","https://openalex.org/W2036842616","https://openalex.org/W2044040065","https://openalex.org/W2047452261","https://openalex.org/W2050887754","https://openalex.org/W2052610203","https://openalex.org/W2053954543","https://openalex.org/W2054455698","https://openalex.org/W2056548409","https://openalex.org/W2057118173","https://openalex.org/W2059841928","https://openalex.org/W2060408981","https://openalex.org/W2060993125","https://openalex.org/W2062409614","https://openalex.org/W2062611394","https://openalex.org/W2063448249","https://openalex.org/W2065865744","https://openalex.org/W2066300705","https://openalex.org/W2067164933","https://openalex.org/W2067455871","https://openalex.org/W2069554621","https://openalex.org/W2071093060","https://openalex.org/W2073576660","https://openalex.org/W2075430187","https://openalex.org/W2075881400","https://openalex.org/W2078189333","https://openalex.org/W2078893156","https://openalex.org/W2081927678","https://openalex.org/W2085136779","https://openalex.org/W2090764201","https://openalex.org/W2091634027","https://openalex.org/W2091634048","https://openalex.org/W2092702426","https://openalex.org/W2093145534","https://openalex.org/W2095719211","https://openalex.org/W2096621401","https://openalex.org/W2098437057","https://openalex.org/W2099164564","https://openalex.org/W2102678034","https://openalex.org/W2105477665","https://openalex.org/W2106017227","https://openalex.org/W2111491759","https://openalex.org/W2113413125","https://openalex.org/W2115395564","https://openalex.org/W2115662151","https://openalex.org/W2123460928","https://openalex.org/W2123865126","https://openalex.org/W2124058652","https://openalex.org/W2124660271","https://openalex.org/W2124733101","https://openalex.org/W2126176654","https://openalex.org/W2126346789","https://openalex.org/W2126850824","https://openalex.org/W2130448025","https://openalex.org/W2137921254","https://openalex.org/W2140205577","https://openalex.org/W2143527074","https://openalex.org/W2146667353","https://openalex.org/W2147579012","https://openalex.org/W2152327707","https://openalex.org/W2155759003","https://openalex.org/W2155957331","https://openalex.org/W2156643487","https://openalex.org/W2156696460","https://openalex.org/W2161656950","https://openalex.org/W2162360553","https://openalex.org/W2164438030","https://openalex.org/W2167531619","https://openalex.org/W2168606329","https://openalex.org/W2168941502","https://openalex.org/W2290028999","https://openalex.org/W2415200025","https://openalex.org/W2438151168"],"related_works":["https://openalex.org/W2017804013","https://openalex.org/W1985756888","https://openalex.org/W2105254630","https://openalex.org/W7095580306","https://openalex.org/W2335114049","https://openalex.org/W2004053219","https://openalex.org/W2951056180","https://openalex.org/W1417711492","https://openalex.org/W7095334486","https://openalex.org/W1963508527"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1,12],"virus":[2,299],"type":[3],"1":[4],"(HIV-1)":[5],"is":[6,16,28,42,82,97,106,120,295],"the":[7,35,45,48,71,85,92,115,136,154,165,169,262,276,312,335],"causative":[8],"agent":[9],"of":[10,34,47,73,87,95,111,117,138,172,186,197,240,250,254,279,286,315,337],"acquired":[11],"syndrome":[13],"(AIDS)":[14],"and":[15,37,55,130,164,211,223,290,347],"a":[17,24,237,258,272,292],"significant":[18],"burden":[19],"on":[20,344],"human":[21],"health.":[22],"As":[23],"successful":[25],"pathogen,":[26],"HIV-1":[27,112,142,155,176,198,241,255,289,324,345],"able":[29],"to":[30,63,109,134,141,175,206,257,269,298,323,333],"overcome":[31],"several":[32],"components":[33],"innate":[36],"adaptive":[38],"immune":[39],"systems.":[40],"This":[41],"facilitated":[43],"by":[44,90,153,190],"activities":[46],"four":[49],"accessory":[50],"proteins":[51,265],"Vif,":[52],"Vpr,":[53],"Vpu,":[54,91],"Nef.":[56],"The":[57],"Vpu":[58],"protein":[59,293,317],"has":[60,101],"been":[61,102],"shown":[62,218,247],"target":[64],"an":[65],"antiviral":[66,93],"protein,":[67,157],"BST-2/tetherin,":[68],"which":[69,235,294],"inhibits":[70],"release":[72],"many":[74],"enveloped":[75],"viruses":[76],"from":[77],"infected":[78,229],"cells.":[79,230,304],"While":[80],"much":[81],"known":[83],"about":[84],"mechanism":[86,116,137],"tetherin":[88,96,105,139,173,187],"antagonism":[89],"function":[94],"poorly":[98],"understood.":[99],"It":[100],"observed":[103],"that":[104,148,183,219,248,308],"specifically":[107,296],"recruited":[108,297],"sites":[110,301],"assembly,":[113],"but":[114],"this":[118,316],"recruitment":[119,140,174,322],"unknown.":[121],"In":[122,231],"my":[123],"thesis":[124],"work":[125,283],"I":[126,145,179,201,305,327],"have":[127,146,180,217,246,306],"employed":[128],"conventional":[129,331],"super-resolution":[131,204],"microscopy":[132,205],"techniques":[133],"determine":[135],"assembly":[143,177,300,325],"sites.":[144,178,326],"determined":[147],"both":[149],"membrane":[150,191,226],"curvature,":[151,192],"mediated":[152],"Gag":[156,163,251,268],"as":[158,160,342],"well":[159],"interactions":[161,208,287],"between":[162,209,288],"ESCRT":[166],"machinery":[167],"are":[168,193,236,318],"critical":[170],"determinants":[171],"also":[181,329],"demonstrated":[182],"low":[184],"levels":[185],"recruitment,":[188],"induced":[189],"sufficient":[194],"for":[195,320],"inhibition":[196],"release.":[199],"Currently":[200],"am":[202,328],"employing":[203,330],"study":[207],"HIV":[210,220],"other":[212],"host":[213,239],"proteins.":[214],"Previously,":[215],"we":[216,245],"interacts":[221],"with":[222,267],"reorganizes":[224],"plasma":[225],"microdomains":[227],"in":[228,243,271,302],"polarized":[232],"T":[233,303],"cells,":[234],"natural":[238],"infection":[242],"vivo,":[244],"multimerization":[249],"mediates":[252],"polarization":[253],"particles":[256],"rear-end":[259],"protrusion":[260],"termed":[261],"uropod.":[263],"Several":[264],"co-polarize":[266],"uropods,":[270],"manner":[273],"dependent":[274],"upon":[275],"matrix":[277],"domain":[278],"Gag.":[280],"My":[281],"current":[282],"involves":[284],"characterization":[285],"PSGL-1,":[291,343],"found":[307],"basic":[309],"residues":[310],"within":[311],"cytoplasmic":[313],"tail":[314],"required":[319],"its":[321],"assays":[332],"examine":[334],"affects":[336],"various":[338],"uropod-directed":[339],"proteins,":[340],"such":[341],"replication":[346],"dissemination.":[348]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}