{"id":"https://openalex.org/W341602972","doi":null,"title":"THE EXPRESSION OF MSX GENES DURING EARLY CRANIAL SUTURE EMBRYOGENESIS","display_name":"THE EXPRESSION OF MSX GENES DURING EARLY CRANIAL SUTURE EMBRYOGENESIS","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W341602972","mag":"341602972"},"language":"en","primary_location":{"id":"mag:341602972","doi":null,"is_oa":false,"landing_page_url":"http://www.ndsl.kr/soc_img/society/kapd/SOCGB@/2003/v30n1/SOCGB@_2003_v30n1_171.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764893290","display_name":"THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY","issn_l":"1226-8496","issn":["1226-8496","2288-3819"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4353108600","host_organization_name":"Korean Academy of Pediatric Dentistry","host_organization_lineage":["https://openalex.org/P4353108600"],"host_organization_lineage_names":["Korean Academy of Pediatric Dentistry"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102875484","display_name":"Sangyoup Lee","orcid":"https://orcid.org/0000-0002-7961-3904","observed_orcids":["https://orcid.org/0000-0002-7961-3904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sangyoup Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7961-3904","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101487936","display_name":"Mi\u2010Hyun Park","orcid":"https://orcid.org/0000-0002-2844-3546","observed_orcids":["https://orcid.org/0000-0002-2844-3546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mi\u2010Hyun Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2844-3546","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006589634","display_name":"Hyun\u2010Mo Ryoo","orcid":"https://orcid.org/0000-0001-6769-8341","observed_orcids":["https://orcid.org/0000-0001-6769-8341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyun\u2010Mo Ryoo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6769-8341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000642212","display_name":"Soon-Hyeun Nam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soon-Hyeun Nam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440455","display_name":"Young\u2010Jin Kim","orcid":"https://orcid.org/0000-0002-7213-5348","observed_orcids":["https://orcid.org/0000-0002-7213-5348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young\u2010Jin Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7213-5348","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100439541","display_name":"Hyun-Jung Kim","orcid":"https://orcid.org/0000-0003-1318-7153","observed_orcids":["https://orcid.org/0000-0003-1318-7153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyun-Jung Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1318-7153","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03548621,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"1","first_page":"171","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/msx1","display_name":"MSX1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/msx2","display_name":"Msx2","score":1.0},{"id":"https://openalex.org/keywords/cranial-sutures","display_name":"cranial sutures","score":0.9120000004768372},{"id":"https://openalex.org/keywords/craniosynostosis","display_name":"craniosynostosis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/sagittal-suture","display_name":"sagittal suture","score":0.7860000133514404},{"id":"https://openalex.org/keywords/coronal-suture","display_name":"coronal suture","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dura-mater","display_name":"dura mater","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.7649999856948853},{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5419999957084656},{"id":"https://openalex.org/keywords/mouse-embryo","display_name":"mouse embryo","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.8683406114578247},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.8174514174461365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7440876364707947},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5645854473114014},{"id":"https://openalex.org/C2779302956","wikidata":"https://www.wikidata.org/wiki/Q378183","display_name":"Craniosynostosis","level":2,"score":0.547814667224884},{"id":"https://openalex.org/C2775853885","wikidata":"https://www.wikidata.org/wiki/Q775497","display_name":"Coronal suture","level":3,"score":0.5339948534965515},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5290535688400269},{"id":"https://openalex.org/C2777327002","wikidata":"https://www.wikidata.org/wiki/Q2865760","display_name":"Fibrous joint","level":2,"score":0.49436521530151367},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47699788212776184},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4190623164176941},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3105512261390686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2870018184185028},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26587486267089844},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.23837009072303772}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:341602972","doi":null,"is_oa":false,"landing_page_url":"http://www.ndsl.kr/soc_img/society/kapd/SOCGB@/2003/v30n1/SOCGB@_2003_v30n1_171.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764893290","display_name":"THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY","issn_l":"1226-8496","issn":["1226-8496","2288-3819"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":"https://openalex.org/P4353108600","host_organization_name":"Korean Academy of Pediatric Dentistry","host_organization_lineage":["https://openalex.org/P4353108600"],"host_organization_lineage_names":["Korean Academy of Pediatric Dentistry"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRY","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2155343233","https://openalex.org/W3010844812","https://openalex.org/W2087321947","https://openalex.org/W1995666993","https://openalex.org/W1991941177","https://openalex.org/W2091371315","https://openalex.org/W2358702239","https://openalex.org/W2513424529","https://openalex.org/W1985648832","https://openalex.org/W1994761385"],"abstract_inverted_index":{"The":[0],"development":[1],"of":[2,11,16,28,37,55,70,88,102,111,118,126,158,181,209,218,242,247,255,267],"calvarial":[3,24],"bones":[4],"is":[5],"tighly":[6],"co-ordinated":[7],"with":[8,96],"the":[9,12,23,42,109,115,124,149,156,161,169,173,177,188,194,238],"growth":[10],"brain":[13],"and":[14,58,64,77,104,135,160,172,191,212,230,240],"needs":[15],"harmonious":[17],"interactions":[18,90,98],"between":[19],"different":[20],"tissues":[21],"within":[22],"sutures.":[25],"Premature":[26],"fusion":[27],"cranial":[29,120,244],"sutures,":[30],"known":[31],"as":[32,68],"craniosynostosis,":[33],"presumably":[34],"involves":[35],"disturbance":[36],"these":[38,225],"interactions.":[39],"Mutations":[40],"in":[41,82,114,129,139,155,168,187,193,236],"homeobox-containg":[43,61],"gene":[44],"Msx2":[45,57,78,164,231],"cause":[46],"human":[47],"craniosynostosis":[48],"syndrome.":[49],"Msx":[50,112,182,248],"genes,":[51,79],"which":[52],"are":[53,60,94,250],"consist":[54],"Msx1,":[56,219],"Msx3,":[59],"transcripton":[62],"factors,":[63],"were":[65,184],"originally":[66],"identified":[67],"homologue":[69],"Drosophila":[71],"msh(muscle":[72],"segment":[73],"homeobox)":[74],"gene.":[75],"Msx1":[76,152,197,211,229],"expressed":[80,154,167,185,192,251],"mostly":[81],"overlapping":[83],"patterns":[84],"at":[85],"multiple":[86],"site":[87],"tissue":[89],"during":[91,99,132],"vertebrate":[92],"development,":[93],"associated":[95],"epithelial-mesenchymal":[97],"organogenesis,":[100],"targets":[101],"BMP":[103],"FGF":[105],"signaling.":[106],"To":[107],"elucidate":[108],"function":[110,260],"genes":[113,183,232,249],"early":[116],"morphogenesis":[117,239],"mouse":[119,141],"suture,":[121,151],"we":[122],"analyzed":[123],"expression":[125,201,208,217],"them":[127],"by":[128],"situ":[130],"hybridization":[131],"embryonic(E15-E18)":[133],"stage,":[134],"did":[136],"vivo":[137],"experiments":[138],"E15.5":[140],"using":[142],"rhBMP-2,":[143],"rhFGF-2":[144],"protein":[145],"soaked":[146],"bead.":[147],"In":[148,176],"sagittal":[150],"was":[153,165],"mesenchyme":[157,171,190],"suture":[159,179],"dura":[162,174],"mater,":[163],"intensely":[166,186],"sutural":[170,189],"mater.":[175],"coronal":[178],"both":[180,210],"periosteum":[195],"also.":[196],"had":[198],"a":[199],"broader":[200],"pattern":[202],"than":[203],"Msx2.":[204,222],"BMP2":[205],"beads":[206,215],"induced":[207,216],"Msx2,":[213],"FGF2":[214],"but":[220,253],"not":[221],"Taken":[223],"together,":[224],"data":[226],"suggest":[227],"that":[228],"have":[233],"important":[234],"role":[235],"regulating":[237],"maintenance":[241],"embryonic":[243],"suture.":[245],"Both":[246],"similarly":[252],"because":[254],"their":[256],"upstream":[257],"signaling,":[258],"they":[259],"dependently":[261],"or":[262],"cooperatively":[263],"according":[264],"to":[265],"change":[266],"signaling":[268],"molecule.":[269]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}