{"id":"https://openalex.org/W341032647","doi":null,"title":"Estresse oxidativo em indiv\u00edduos com s\u00edndrome de Li-Fraumeni-like e portadores da muta\u00e7\u00e3o germinativa TP53 p.R337H","display_name":"Estresse oxidativo em indiv\u00edduos com s\u00edndrome de Li-Fraumeni-like e portadores da muta\u00e7\u00e3o germinativa TP53 p.R337H","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W341032647","mag":"341032647"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:3181405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10183/60543","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110822488","display_name":"Gabriel de Souza Macedo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gabriel de Souza Macedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110822488"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.5853999853134155,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1842000037431717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.09130000323057175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9150000214576721},{"id":"https://openalex.org/keywords/li-fraumeni-syndrome","display_name":"Li-Fraumeni syndrome","score":0.9089999794960022},{"id":"https://openalex.org/keywords/li-fraumeni-like-syndrome","display_name":"Li-Fraumeni-like syndrome","score":0.9200000166893005},{"id":"https://openalex.org/keywords/germline-tp53-mutation","display_name":"germline TP53 mutation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.8659999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9639999866485596},{"id":"https://openalex.org/keywords/protein-carbonylation","display_name":"protein carbonylation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.847000002861023},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.7680000066757202},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2777169287","wikidata":"https://www.wikidata.org/wiki/Q187542","display_name":"Li\u2013Fraumeni syndrome","level":5,"score":0.6380883455276489},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4104093909263611},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38796135783195496},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35912707448005676},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2945830821990967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20739591121673584},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1194424033164978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0700438916683197},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:americanae.aecid.es:3181405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/210359","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/210359","pdf_url":"http://hdl.handle.net/10183/210359","source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Resumo publicado em evento"},{"id":"pmh:oai:lume.ufrgs.br:10183/60543","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60543","pdf_url":null,"source":{"id":"https://openalex.org/S4306401468","display_name":"Lume (Universidade Federal do Rio Grande do Sul)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210097146","host_organization_name":"Hospital de Cl\u00ednicas de Porto Alegre","host_organization_lineage":["https://openalex.org/I4210097146"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Disserta\u00e7\u00e3o"},{"id":"pmh:oai:www.lume.ufrgs.br:10183/60543","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60543","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:341032647","doi":null,"is_oa":false,"landing_page_url":"https://www.lume.ufrgs.br/bitstream/handle/10183/60543/000856361.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3181405","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10183/60543","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es da UFRGS","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W341032647.pdf","grobid_xml":"https://content.openalex.org/works/W341032647.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W161782498","https://openalex.org/W1650797637","https://openalex.org/W1750690213","https://openalex.org/W1775749144","https://openalex.org/W1961179371","https://openalex.org/W1969261030","https://openalex.org/W1970399383","https://openalex.org/W1986076152","https://openalex.org/W1988587584","https://openalex.org/W1989032142","https://openalex.org/W1989851980","https://openalex.org/W1991494214","https://openalex.org/W1996463845","https://openalex.org/W1997732467","https://openalex.org/W2001372725","https://openalex.org/W2003471941","https://openalex.org/W2005542290","https://openalex.org/W2007023752","https://openalex.org/W2008257691","https://openalex.org/W2008933923","https://openalex.org/W2010077871","https://openalex.org/W2010094123","https://openalex.org/W2022059814","https://openalex.org/W2027605252","https://openalex.org/W2028810780","https://openalex.org/W2029679807","https://openalex.org/W2029762798","https://openalex.org/W2034059961","https://openalex.org/W2036566995","https://openalex.org/W2036639619","https://openalex.org/W2038091430","https://openalex.org/W2051611229","https://openalex.org/W2051972371","https://openalex.org/W2054549064","https://openalex.org/W2057854840","https://openalex.org/W2059643569","https://openalex.org/W2059880490","https://openalex.org/W2059985270","https://openalex.org/W2061233123","https://openalex.org/W2067904115","https://openalex.org/W2071603995","https://openalex.org/W2073576377","https://openalex.org/W2074177998","https://openalex.org/W2075230059","https://openalex.org/W2077644294","https://openalex.org/W2095834651","https://openalex.org/W2098951927","https://openalex.org/W2102472842","https://openalex.org/W2108158811","https://openalex.org/W2109178988","https://openalex.org/W2118232192","https://openalex.org/W2120961400","https://openalex.org/W2121010990","https://openalex.org/W2125863862","https://openalex.org/W2129769331","https://openalex.org/W2133959309","https://openalex.org/W2140986588","https://openalex.org/W2147785354","https://openalex.org/W2147993424","https://openalex.org/W2152319713","https://openalex.org/W2154799239","https://openalex.org/W2156257249","https://openalex.org/W2157455826","https://openalex.org/W2157618054","https://openalex.org/W2169129430","https://openalex.org/W2174418452","https://openalex.org/W2476895759"],"related_works":["https://openalex.org/W2057405277","https://openalex.org/W2620347334","https://openalex.org/W2090119503","https://openalex.org/W7046206890","https://openalex.org/W2739457561","https://openalex.org/W2338335852","https://openalex.org/W2271028365","https://openalex.org/W2075558761","https://openalex.org/W2285305981","https://openalex.org/W6986141002"],"abstract_inverted_index":{"Muta\u00e7\u00f5es":[0],"germinativas":[1],"no":[2,126,142,149],"gene":[3],"TP53":[4,67,171],"est\u00e3o":[5],"associadas":[6],"com":[7,38,71,98],"a":[8,15,26,79,119],"S\u00edndrome":[9,16],"de":[10,17,55,61,107,111,114,151,163,180,194],"Li-Fraumeni":[11],"e":[12,93,110,118,132,176],"sua":[13],"variante,":[14],"Li-Fraumeni-Like,":[18],"ambas":[19],"doen\u00e7as":[20],"autoss\u00f4micas":[21],"dominantes":[22],"caracterizadas":[23],"pela":[24],"predisposi\u00e7\u00e3o":[25,189],"m\u00faltiplos":[27],"tumores":[28],"em":[29,58,69,154,165],"idade":[30,175],"precoce.Recentemente":[31],"p53":[32,164],"foi":[33,52],"descrita":[34],"como":[35],"uma":[36,85,147],"prote\u00edna":[37,117],"fun\u00e7\u00f5es":[39],"antioxidantes,":[40],"atuando":[41],"na":[42],"manuten\u00e7\u00e3o":[43],"da":[44,64,75,82,96,101,137,160,168,174],"estabilidade":[45],"gen\u00f4mica.Sendo":[46],"assim,":[47],"o":[48],"objetivo":[49],"deste":[50],"trabalho":[51],"investigar":[53],"par\u00e2metros":[54],"estresse":[56],"oxidativo":[57],"sangue":[59],"perif\u00e9rico":[60],"indiv\u00edduos":[62,72,135,166],"portadores":[63,74,92,95,136,167],"muta\u00e7\u00e3o":[65,138,169],"germinativa":[66,170],"p.R337H":[68],"compara\u00e7\u00e3o":[70],"n\u00e3o":[73,94],"altera\u00e7\u00e3o.Foi":[76],"verificado":[77],"que":[78],"atividade":[80,102],"eritrocit\u00e1ria":[81],"enzima":[83],"GPx,":[84],"importante":[86],"defesa":[87],"antioxidante,":[88],"diferiu":[89],"significativamente":[90,124],"entre":[91],"muta\u00e7\u00e3o,":[97],"um":[99,140,181],"aumento":[100,141],"nos":[103],"primeiros":[104],"(p=0.048).O":[105],"conte\u00fado":[106,150],"grupamentos":[108],"carbonila":[109],"malondialde\u00eddo,":[112],"indicadores":[113],"dano":[115],"\u00e0":[116,188],"lip\u00eddios,":[120],"respectivamente,":[121],"tamb\u00e9m":[122],"foram":[123],"maiores":[125],"grupo":[127,193],"dos":[128],"p":[129],"ortadores":[130],"(p=0.04":[131],"p<0.0001).Por":[133],"fim,":[134],"apresentaram":[139],"estado":[143],"antioxidante":[144,162],"total,":[145],"mas":[146],"diminui\u00e7\u00e3o":[148],"\u00e1cido":[152],"asc\u00f3rbico":[153],"plasma.Nossos":[155],"resultados":[156],"apontam":[157],"para":[158],"altera\u00e7\u00f5es":[159,183],"fun\u00e7\u00e3o":[161],"p.R337H,":[172],"independentemente":[173],"do":[177],"diagn\u00f3stico":[178],"pr\u00e9vio":[179],"tumor.Estas":[182],"podem":[184],"estar":[185],"diretamente":[186],"relacionadas":[187],"ao":[190],"c\u00e2ncer":[191],"neste":[192],"pacientes.":[195]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}