{"id":"https://openalex.org/W340820028","doi":null,"title":"Gene Expression and Alzheimer's Disease: Evaluation of Gene Expression Patterns in Brain and Blood for an Alzheimer's Disease Mouse Model","display_name":"Gene Expression and Alzheimer's Disease: Evaluation of Gene Expression Patterns in Brain and Blood for an Alzheimer's Disease Mouse Model","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W340820028","mag":"340820028"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.liberty.edu:honors-1521","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.liberty.edu/honors/497","pdf_url":"https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1521&context=honors","source":{"id":"https://openalex.org/S4306400581","display_name":"Digital Commons (Liberty University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67789559","host_organization_name":"Liberty University","host_organization_lineage":["https://openalex.org/I67789559"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Honors Theses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1521&context=honors","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083693282","display_name":"Amanda Hazy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amanda Hazy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5083693282"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00321798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9610000252723694},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7089999914169312},{"id":"https://openalex.org/keywords/mir-17","display_name":"miR-17","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9120000004768372},{"id":"https://openalex.org/keywords/blood-transcriptome","display_name":"blood transcriptome","score":0.875},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.871999979019165},{"id":"https://openalex.org/keywords/mouse-models-of-alzheimer-s-disease","display_name":"mouse models of Alzheimer's disease","score":0.7850000262260437},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8230000138282776}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.7247032523155212},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7026203274726868},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5722797513008118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4544040560722351},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4525845944881439},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.45182013511657715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4439356327056885},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34669703245162964},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28787732124328613},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17200186848640442},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0681973397731781},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.liberty.edu:honors-1521","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.liberty.edu/honors/497","pdf_url":"https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1521&context=honors","source":{"id":"https://openalex.org/S4306400581","display_name":"Digital Commons (Liberty University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67789559","host_organization_name":"Liberty University","host_organization_lineage":["https://openalex.org/I67789559"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Honors Theses","raw_type":"text"},{"id":"mag:340820028","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1521&context=honors","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.liberty.edu:honors-1521","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.liberty.edu/honors/497","pdf_url":"https://digitalcommons.liberty.edu/cgi/viewcontent.cgi?article=1521&context=honors","source":{"id":"https://openalex.org/S4306400581","display_name":"Digital Commons (Liberty University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67789559","host_organization_name":"Liberty University","host_organization_lineage":["https://openalex.org/I67789559"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Senior Honors Theses","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W340820028.pdf","grobid_xml":"https://content.openalex.org/works/W340820028.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W142208266","https://openalex.org/W168279297","https://openalex.org/W1521541385","https://openalex.org/W1566270348","https://openalex.org/W1772878786","https://openalex.org/W1901162059","https://openalex.org/W1917905880","https://openalex.org/W1963793691","https://openalex.org/W1964589079","https://openalex.org/W1971922487","https://openalex.org/W1972862259","https://openalex.org/W1980912292","https://openalex.org/W1980940682","https://openalex.org/W1981322456","https://openalex.org/W1981546185","https://openalex.org/W1981702595","https://openalex.org/W1985342884","https://openalex.org/W1990061381","https://openalex.org/W1992120851","https://openalex.org/W1993136341","https://openalex.org/W1995509509","https://openalex.org/W1996241541","https://openalex.org/W1997609831","https://openalex.org/W2001179326","https://openalex.org/W2003268936","https://openalex.org/W2006467356","https://openalex.org/W2006876731","https://openalex.org/W2007961618","https://openalex.org/W2009075843","https://openalex.org/W2013602457","https://openalex.org/W2015490507","https://openalex.org/W2017026565","https://openalex.org/W2019845348","https://openalex.org/W2019945818","https://openalex.org/W2021956333","https://openalex.org/W2024905696","https://openalex.org/W2026303819","https://openalex.org/W2031969613","https://openalex.org/W2033105784","https://openalex.org/W2037584836","https://openalex.org/W2043642541","https://openalex.org/W2044783100","https://openalex.org/W2045169230","https://openalex.org/W2046006229","https://openalex.org/W2051029644","https://openalex.org/W2051359509","https://openalex.org/W2054360935","https://openalex.org/W2064861163","https://openalex.org/W2066480609","https://openalex.org/W2068894842","https://openalex.org/W2073690379","https://openalex.org/W2074274706","https://openalex.org/W2074528387","https://openalex.org/W2074938894","https://openalex.org/W2078210863","https://openalex.org/W2084762017","https://openalex.org/W2088440542","https://openalex.org/W2091767438","https://openalex.org/W2092197373","https://openalex.org/W2094105781","https://openalex.org/W2096321911","https://openalex.org/W2097065948","https://openalex.org/W2100305481","https://openalex.org/W2102072515","https://openalex.org/W2104488717","https://openalex.org/W2104822288","https://openalex.org/W2107493728","https://openalex.org/W2110412832","https://openalex.org/W2116064001","https://openalex.org/W2116622558","https://openalex.org/W2122866775","https://openalex.org/W2122981189","https://openalex.org/W2127932580","https://openalex.org/W2132582013","https://openalex.org/W2133538808","https://openalex.org/W2139655181","https://openalex.org/W2141458291","https://openalex.org/W2141792156","https://openalex.org/W2142663409","https://openalex.org/W2148535178","https://openalex.org/W2155636551","https://openalex.org/W2159677246","https://openalex.org/W2169727478","https://openalex.org/W2170644095","https://openalex.org/W2332500686","https://openalex.org/W2333248224"],"related_works":["https://openalex.org/W310280502","https://openalex.org/W175827031","https://openalex.org/W2538843994","https://openalex.org/W6908073654","https://openalex.org/W4293536424","https://openalex.org/W2351024772","https://openalex.org/W2765420908","https://openalex.org/W2521567832","https://openalex.org/W2620659077","https://openalex.org/W7166822248"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"established":[3],"a":[4],"causative":[5],"role":[6],"for":[7],"altered":[8],"gene":[9,105],"expression":[10,30,45,68,93,106],"in":[11,38,72,80,84,114],"development":[12],"of":[13,31,51,57,69],"Alzheimer\u2019s":[14],"disease":[15],"(AD).":[16],"These":[17],"changes":[18,46,107],"can":[19],"be":[20],"affected":[21],"by":[22,42,49],"methylation":[23,36],"and":[24,55,59,74,86,110],"miRNA":[25,32],"regulation.":[26],"In":[27],"this":[28,101],"study,":[29],"known":[33],"to":[34],"change":[35],"status":[37],"AD":[39,60,109,118],"was":[40],"assessed":[41],"qPCR.":[43],"Genome-wide":[44],"were":[47],"determined":[48],"RNA-sequencing":[50],"mRNA":[52],"from":[53,100],"hippocampus":[54],"blood":[56,115],"control":[58],"mice.":[61],"The":[62],"qPCR":[63],"data":[64,76,99],"showed":[65],"significantly":[66],"increased":[67],"Mir":[70],"17":[71],"AD,":[73],"sequencing":[75],"revealed":[77,103],"230":[78],"genes":[79,83,89,113],"hippocampus,":[81],"58":[82],"blood,":[85],"8":[87],"overlapping":[88],"showing":[90],"significant":[91],"differential":[92],"(p":[94],"value":[95],"\u2264":[96],"0.05).":[97],"Expression":[98],"study":[102],"novel":[104],"affecting":[108],"identified":[111],"changing":[112],"as":[116],"potential":[117],"biomarkers.":[119]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}