{"id":"https://openalex.org/W340259138","doi":null,"title":"Anti-P185~(erbB2) scFv-Fc-IL-2 modulates tumor cell surface molecules and activates immune effector cells","display_name":"Anti-P185~(erbB2) scFv-Fc-IL-2 modulates tumor cell surface molecules and activates immune effector cells","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W340259138","mag":"340259138"},"language":"en","primary_location":{"id":"mag:2382551210","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTotal-ZLSW200606006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Cancer","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084169778","display_name":"Jun Wang","orcid":"https://orcid.org/0000-0003-0064-3551","observed_orcids":["https://orcid.org/0000-0003-0064-3551","https://orcid.org/0000-0002-1169-3071","https://orcid.org/0000-0002-2755-7031","https://orcid.org/0000-0001-9115-3755","https://orcid.org/0009-0004-5785-3626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0064-3551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061494975","display_name":"zhang guo ling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"zhang guo ling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039192349","display_name":"\u987e\u6d2a\u6d9b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u987e\u6d2a\u6d9b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060143558","display_name":"Ning Guo","orcid":"https://orcid.org/0009-0005-5706-6400","observed_orcids":["https://orcid.org/0009-0005-5706-6400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-5706-6400","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033603470","display_name":"\u65bd\u660e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u65bd\u660e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084063243","display_name":"\u6c88\u500d\u594b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6c88\u500d\u594b","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081228008","display_name":"\u6bdb\u6d77\u5a77","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6bdb\u6d77\u5a77","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091579723","display_name":"\u674e\u7fe0\u73b2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u7fe0\u73b2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057499674","display_name":"\u6e29\u57f9\u5a25","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6e29\u57f9\u5a25","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3080,"currency":"USD","value_usd":3080},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03428019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"6","first_page":"412","last_page":"416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8535000085830688,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fas-fasl-pathway","display_name":"Fas/FasL pathway","score":0.9620000123977661},{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.7490000128746033},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.282653272151947}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2382551210","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTotal-ZLSW200606006.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306555428","display_name":"\u764c\u75c7\uff1a\u82f1\u6587\u7248","issn_l":"1000-467X","issn":["1000-467X","1944-446X","2523-3548"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","dongbi-b","ki-jl-1","medline","norway-2","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Cancer","raw_type":null},{"id":"mag:340259138","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90527X/200606/23489968.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542217","display_name":"\u4e2d\u56fd\u80bf\u7624\u751f\u7269\u6cbb\u7597\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u80bf\u7624\u751f\u7269\u6cbb\u7597\u6742\u5fd7","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1017714796","https://openalex.org/W2382551210","https://openalex.org/W3147324381","https://openalex.org/W2040920410","https://openalex.org/W344224624","https://openalex.org/W2262099091","https://openalex.org/W2373542352","https://openalex.org/W3149574055","https://openalex.org/W962870215","https://openalex.org/W3032549817"],"abstract_inverted_index":{"\u76ee\u7684\uff1a\u5c06\u6297\u4ebaP185erbB2scFv-Fc-IL-2\u878d\u5408\u86cb\u767d\uff08HFI\uff09\u4f5c\u7528\u4e8e\u4eba\u5375\u5de2\u764c\u7ec6\u80de\u682aSKOV3\u7ec6\u80de\u548c\u4eba\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de\uff08PBMC\uff09\uff0c\u901a\u8fc7\u4f53\u5916\u5b9e\u9a8c\u9610\u660eHFI\u8c03\u53d8\u80bf\u7624\u7ec6\u80de\u8868\u9762\u5206\u5b50\u548c\u6fc0\u6d3b\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7684\u6297\u80bf\u7624\u673a\u5236\uff0c\u4e3aHFI\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u5b9e\u9a8c\u4f9d\u636e\u3002\u65b9\u6cd5\uff1aMTT\u6cd5\u68c0\u6d4b\u7ec6\u80de\u589e\u6b96\u3001\u6740\u4f24\u6d3b\u6027\uff1b\u6d41\u5f0f\u7ec6\u80de\u672f\u89c2\u5bdf\u7ec6\u80de\u8868\u9762\u5206\u5b50\u7684\u8868\u8fbe\u6c34\u5e73\uff1b\u751f\u7269\u6d3b\u6027\u6cd5\u68c0\u6d4b\u7ec6\u80de\u819c\u76f8\u5173TNF\u6740\u4f24\u6d3b\u6027\uff1bRT\u2014PCR\u68c0\u6d4b\u7ec6\u80de\u7a7f\u5b54\u7d20\u8868\u8fbe\u6c34\u5e73\u3002\u7ed3\u679c\uff1aHFI\u5904\u7406\u540e\uff0c\u672a\u89c2\u5bdf\u5230\u5bf9SKOV3\u7ec6\u80de\u589e\u6b96\u6d3b\u6027\u7684\u76f4\u63a5\u6291\u5236\u4f5c\u7528\uff1bSKOV3\u7ec6\u80de\u8868\u9762\u6740\u4f24\u76f8\u5173\u5206\u5b50ICAM-1\u3001Fas\u8868\u8fbe\u7387\u5206\u522b\u753124\uff0e85\uff05\u30010\uff0e53\uff05\u589e\u9ad8\u523085\uff0e36\uff05\u300159\uff0e19\uff05\uff08P\u30080\uff0e01\uff09\uff1b\u4ebaPBMC\u7684\u589e\u6b96\u6d3b\u6027\u589e\u5f3a\uff0cCD3^\uff0bCD8^\uff0bT\u7ec6\u80de\u548cCD3^\uff0bCD16^\uff0bCD56^\uff0bNK\u7ec6\u80de\u5206\u522b\u753124\uff0e37\uff05\u30016\uff0e90\uff05\u63d0\u9ad8\u523038\uff0e80\uff05\u300113\uff0e45\uff05\uff08P\u30080\uff0e01\uff09\uff1bCD25\u3001LFA-1\u3001FasL\u8868\u8fbe\u6c34\u5e73\u5206\u522b\u75313\uff0e99\uff05\u300186\uff0e52\uff05\u30015\uff0e02\uff05\u63d0\u9ad8\u523012\uff0e96\uff05\u300199\uff0e06\uff0516\uff0e19\uff05\uff08P\u30080\uff0e01\uff09\uff1b\u7a7f\u5b54\u7d20\u57fa\u56e0\u3001\u819c\u76f8\u5173TNF\u5747\u8868\u8fbe\u589e\u5f3a\uff0cLAK\u6837\u3001NK\u6837\u6740\u4f24\u6d3b\u6027\u5728\u5404\u6548\u9776\u6bd4\u65f6\u5747\u660e\u663e\u589e\u9ad8\uff08P\u30080\uff0e01\uff09\u3002\u7ed3\u8bba\uff1aHFI\u63d0\u9ad8SKOV3\u7ec6\u80de\u6740\u4f24\u76f8\u5173\u5206\u5b50ICAM-1\u3001Fas\u8868\u8fbe\u6c34\u5e73\uff0c\u5e76\u4e14\u5bf9\u4ebaPBMC\u6709\u660e\u663e\u7684\u589e\u6b96\u6d3b\u5316\u4f5c\u7528\uff0c\u901a\u8fc7\u6fc0\u6d3bLFA-1\uff0fICAM-1\u3001Fas\uff0fFasL\u9014\u5f84\u63d0\u9ad8\u6740\u4f24\u4ecb\u8d28\u7a7f\u5b54\u7d20\u548c\u819c\u76f8\u5173TNF\u7684\u91ca\u653e\uff0c\u589e\u5f3aLAK\u6837\u3001NK\u6837\u6740\u4f24\u6d3b\u6027\u3002":[0]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}