{"id":"https://openalex.org/W34006632","doi":null,"title":"[Autoimmune hepatitis in Tunisia. Retrospective multicenter study of 83 cases].","display_name":"[Autoimmune hepatitis in Tunisia. Retrospective multicenter study of 83 cases].","publication_year":2010,"publication_date":"2010-11-01","ids":{"openalex":"https://openalex.org/W34006632","mag":"34006632","pmid":"https://pubmed.ncbi.nlm.nih.gov/21049414"},"language":"fr","primary_location":{"id":"pmid:21049414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21049414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Tunisie medicale","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109274692","display_name":"Radhouane Debbeche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118449","display_name":"H\u00f4pital Charles-Nicolle","ror":"https://ror.org/02f6ghw27","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210118449"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Radhouane Debbeche","raw_affiliation_strings":["Service de Gastro-ent\u00e9rologie, H\u00f4pital Charles Nicolle, Tunis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Gastro-ent\u00e9rologie, H\u00f4pital Charles Nicolle, Tunis","institution_ids":["https://openalex.org/I4210118449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052598262","display_name":"Nadia Maamouri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia Maamouri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113646465","display_name":"Salem Ajmi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salem Ajmi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088923620","display_name":"Mohamed Moussadak Azzouz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Moussaddek Azzouz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110250470","display_name":"Nabyl Ben Mami","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nabyl Ben Mami","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078338549","display_name":"Mohamed H\u00e9di Dougui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed H\u00e9di Dougui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111683343","display_name":"Azza Filali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azza Filali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081656615","display_name":"Abdeljabbar Ghorbel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdeljabbar Ghorbel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050506171","display_name":"F Khedhiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faouzi Khedhiri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063173279","display_name":"Mohamed Salah Krichene","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Salah Krichene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021751347","display_name":"Taoufik Najjar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taoufik Najjar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108590272","display_name":"Hammouda Saffar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hammouda Saffar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111966451","display_name":"B\u00e9chir Zouari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u00e9chir Zouari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.00349476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"88","issue":"11","first_page":"834","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-1-autoimmune-hepatitis","display_name":"type 1 autoimmune hepatitis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/type-2-autoimmune-hepatitis","display_name":"type 2 autoimmune hepatitis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.44600000977516174},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6740000247955322},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.8100000023841858},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8820000290870667},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/encephalopathy","display_name":"encephalopathy","score":0.7580000162124634},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.8299999833106995},{"id":"https://openalex.org/keywords/overlap-syndrome","display_name":"overlap syndrome","score":0.5950000286102295},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.968999981880188},{"id":"https://openalex.org/keywords/tunisia","display_name":"Tunisia","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.9300320148468018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9192563891410828},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.8326675891876221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6518197059631348},{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.5896782875061035},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.567894458770752},{"id":"https://openalex.org/C2776362883","wikidata":"https://www.wikidata.org/wiki/Q187842","display_name":"Autoimmune thyroiditis","level":4,"score":0.5585203170776367},{"id":"https://openalex.org/C2775941666","wikidata":"https://www.wikidata.org/wiki/Q7113759","display_name":"Overlap syndrome","level":3,"score":0.5069553852081299},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.47857382893562317},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4732953906059265},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4415481388568878},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.4349965751171112},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.42280322313308716},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36594247817993164},{"id":"https://openalex.org/C2778696486","wikidata":"https://www.wikidata.org/wiki/Q11835644","display_name":"Thyroiditis","level":3,"score":0.19694563746452332}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21049414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21049414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Tunisie medicale","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W108864726","https://openalex.org/W2010525947","https://openalex.org/W3010647078","https://openalex.org/W2020434964","https://openalex.org/W1918071125","https://openalex.org/W2968842334","https://openalex.org/W4316040189","https://openalex.org/W2922291491","https://openalex.org/W4392565309","https://openalex.org/W2037296823"],"abstract_inverted_index":{"BACKGROUND:":[0],"Autoimmune":[1],"hepatitis":[2,88],"(AIH)":[3],"is":[4],"a":[5,213,279,303],"chronic":[6],"inflammatory":[7],"condition":[8],"of":[9,12,36,48,72,80,84,123,132,141,171,178,186,207,216,229,243,267,282],"the":[10,78,81,85,116,142,275,293],"liver":[11],"unknown":[13,24],"etiology.":[14],"Its":[15],"epidemiological":[16,263],"and":[17,20,33,38,46,61,106,129,161,180,232,255,264,299],"anatomoclinical":[18],"characteristics":[19,266],"its":[21],"outcome":[22],"were":[23,64,95,125,134,144,190,249,269],"in":[25,51,66,153,169,176,184,197,205,240,274],"Tunisia.":[26,52],"AIM:":[27],"To":[28],"analyse":[29],"epidemiological,":[30],"anatomoclinical,":[31],"immunological":[32],"histological":[34],"aspects":[35],"AIH":[37,57,73,105,128,268],"to":[39,77,271],"determine":[40],"factors":[41],"predicting":[42],"relapse":[43,222,298],"after":[44],"treatment":[45,224,256],"death":[47,248],"this":[49],"disease":[50],"METHODS:":[53],"Patients":[54],"presenting":[55],"with":[56,115,199,221,225,247,257,278,287,297,301,306],"between":[58],"January":[59],"1996":[60],"December":[62],"2004":[63],"evaluated":[65],"retrospective":[67],"multicentric":[68],"study.":[69],"The":[70],"diagnosis":[71],"was":[74,151,167,203,238,292],"established":[75],"according":[76],"criteria":[79],"revised":[82],"score":[83],"international":[86],"autoimmune":[87,149,159],"group":[89],"(1999)":[90],"RESULTS:":[91],"Eighty":[92,119],"three":[93,120],"patients":[94,143,189],"identified":[96],"(70":[97],"female;":[98],"mean":[99],"age=49+17.9":[100],"years).":[101],"63%":[102],"presented":[103,108,114],"probable":[104],"37%":[107],"definite":[109],"AIH.":[110],"Thirty":[111],"two":[112],"percent":[113,140,210],"acute":[117],"pattern.":[118],"per":[121],"cent":[122],"cases":[124,133,179],"type":[126,135],"I":[127],"5":[130],"%":[131,242],"II":[136],"HAI.":[137],"Fifty":[138,188],"seven":[139],"cirrhotic":[145],"at":[146,284],"presentation.":[147,285],"Associated":[148],"diseases":[150],"seen":[152],"27":[154],"patients,":[155],"dominated":[156],"by":[157,192],"diabetes,":[158],"thyroiditis":[160],"Sj\u00f6gren's":[162],"syndrome.":[163],"An":[164],"overlap":[165],"syndrome":[166],"diagnosed":[168],"25%":[170],"cases;":[172],"primary":[173,181],"biliary":[174],"Cirrhosis-AIH":[175],"20%":[177],"sclerosing":[182],"cholangitis-AIH":[183],"5%":[185],"cases.":[187,208,244],"treated":[191],"glucocorticoids":[193],"as":[194,251],"monotherapy":[195],"or":[196],"combination":[198],"azathioprine.":[200],"Complete":[201],"remission":[202],"achieved":[204],"90%":[206],"Fourteen":[209],"relapsed":[211],"within":[212],"median":[214],"time":[215],"12":[217],"months.":[218,259],"Factors":[219,245],"associated":[220,246,296,305],"were:":[223],"Azathioprine<18":[226,258],"months,":[227],"absence":[228],"lobular":[230],"necrosis":[231],"anti-nuclear":[233],"antibody":[234],"(+)":[235],"profile.":[236],"Mortality":[237],"observed":[239],"17":[241],"encephalopathy":[250,302],"an":[252],"independent":[253],"factor":[254,295,304],"CONCLUSION:":[260],"In":[261],"Tunisia,":[262],"clinical":[265],"similar":[270],"those":[272],"reported":[273],"literature":[276],"but":[277],"higher":[280],"frequency":[281],"cirrhosis":[283],"Treatment":[286],"Azathioprine":[288],"<":[289],"18":[290],"months":[291],"main":[294],"represented":[300],"death.":[307]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}