{"id":"https://openalex.org/W339589975","doi":null,"title":"Input-specific organization of cellular and subcellular connectivity in superficial layers of the prefrontal cortex","display_name":"Input-specific organization of cellular and subcellular connectivity in superficial layers of the prefrontal cortex","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W339589975","mag":"339589975"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3602689","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3602689","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3602689","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031512174","display_name":"Justin P. Little","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Little, Justin P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031512174"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.9769999980926514},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"functional connectivity","score":0.6449999809265137},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.746999979019165},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.8050000071525574},{"id":"https://openalex.org/keywords/layer-2","display_name":"Layer 2","score":0.7789999842643738},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.7289999723434448},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/emotional-control","display_name":"emotional control","score":0.7699999809265137},{"id":"https://openalex.org/keywords/synaptic-targeting","display_name":"synaptic targeting","score":0.5830000042915344},{"id":"https://openalex.org/keywords/optogenetics","display_name":"optogenetics","score":0.5789999961853027},{"id":"https://openalex.org/keywords/two-photon-microscopy","display_name":"two-photon microscopy","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6521379947662354},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.557701826095581},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3769337236881256},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3723424971103668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34835371375083923},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1097756028175354}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3602689","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3602689","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3602689","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":277,"referenced_works":["https://openalex.org/W173603340","https://openalex.org/W1486520839","https://openalex.org/W1489513029","https://openalex.org/W1499578761","https://openalex.org/W1516345629","https://openalex.org/W1549050411","https://openalex.org/W1551756182","https://openalex.org/W1552487630","https://openalex.org/W1557481078","https://openalex.org/W1559348600","https://openalex.org/W1563017295","https://openalex.org/W1566654154","https://openalex.org/W1566861944","https://openalex.org/W1588643584","https://openalex.org/W1596185512","https://openalex.org/W1620103507","https://openalex.org/W1637489043","https://openalex.org/W1763296052","https://openalex.org/W1780715584","https://openalex.org/W1798313689","https://openalex.org/W1809216657","https://openalex.org/W1836832549","https://openalex.org/W1845163922","https://openalex.org/W1849447353","https://openalex.org/W1866333058","https://openalex.org/W1878427780","https://openalex.org/W1925663400","https://openalex.org/W1934624205","https://openalex.org/W1953927931","https://openalex.org/W1966123655","https://openalex.org/W1966307937","https://openalex.org/W1966681799","https://openalex.org/W1967324141","https://openalex.org/W1967804600","https://openalex.org/W1967887989","https://openalex.org/W1969161388","https://openalex.org/W1969584830","https://openalex.org/W1971887764","https://openalex.org/W1972529694","https://openalex.org/W1972815737","https://openalex.org/W1974098012","https://openalex.org/W1974424738","https://openalex.org/W1974893701","https://openalex.org/W1974971758","https://openalex.org/W1976401996","https://openalex.org/W1976587054","https://openalex.org/W1976738367","https://openalex.org/W1979009696","https://openalex.org/W1979356066","https://openalex.org/W1981349335","https://openalex.org/W1982241694","https://openalex.org/W1983553517","https://openalex.org/W1985450720","https://openalex.org/W1986287415","https://openalex.org/W1987510656","https://openalex.org/W1990389323","https://openalex.org/W1990397347","https://openalex.org/W1991148015","https://openalex.org/W1991233288","https://openalex.org/W1991444801","https://openalex.org/W1991481439","https://openalex.org/W1991864133","https://openalex.org/W1992616517","https://openalex.org/W1992728373","https://openalex.org/W1995341919","https://openalex.org/W1996712322","https://openalex.org/W1997381540","https://openalex.org/W1997862361","https://openalex.org/W1998961405","https://openalex.org/W1999149787","https://openalex.org/W1999615421","https://openalex.org/W1999838582","https://openalex.org/W1999968276","https://openalex.org/W2000616436","https://openalex.org/W2001728178","https://openalex.org/W2003039550","https://openalex.org/W2003292964","https://openalex.org/W2004643793","https://openalex.org/W2005156903","https://openalex.org/W2005266832","https://openalex.org/W2005465545","https://openalex.org/W2006406301","https://openalex.org/W2008520902","https://openalex.org/W2008595762","https://openalex.org/W2008795575","https://openalex.org/W2009365661","https://openalex.org/W2009797032","https://openalex.org/W2010975466","https://openalex.org/W2012533002","https://openalex.org/W2012568486","https://openalex.org/W2012661701","https://openalex.org/W2013115334","https://openalex.org/W2013659331","https://openalex.org/W2016190349","https://openalex.org/W2020871845","https://openalex.org/W2021282423","https://openalex.org/W2021760975","https://openalex.org/W2022050643","https://openalex.org/W2022286642","https://openalex.org/W2022777861","https://openalex.org/W2022995207","https://openalex.org/W2024034126","https://openalex.org/W2024174536","https://openalex.org/W2025206376","https://openalex.org/W2026108792","https://openalex.org/W2027281915","https://openalex.org/W2027616533","https://openalex.org/W2028346529","https://openalex.org/W2028848126","https://openalex.org/W2029318834","https://openalex.org/W2030531936","https://openalex.org/W2031167848","https://openalex.org/W2031534534","https://openalex.org/W2032192786","https://openalex.org/W2032404387","https://openalex.org/W2033708181","https://openalex.org/W2034139708","https://openalex.org/W2036182292","https://openalex.org/W2037528692","https://openalex.org/W2038595565","https://openalex.org/W2039436203","https://openalex.org/W2040038329","https://openalex.org/W2040527392","https://openalex.org/W2040879146","https://openalex.org/W2041457323","https://openalex.org/W2042125519","https://openalex.org/W2042404539","https://openalex.org/W2042479971","https://openalex.org/W2042808523","https://openalex.org/W2042934979","https://openalex.org/W2043212816","https://openalex.org/W2044833738","https://openalex.org/W2044870013","https://openalex.org/W2045426666","https://openalex.org/W2045591619","https://openalex.org/W2045721385","https://openalex.org/W2046033738","https://openalex.org/W2046900303","https://openalex.org/W2046924947","https://openalex.org/W2050639539","https://openalex.org/W2051743763","https://openalex.org/W2053358664","https://openalex.org/W2054077218","https://openalex.org/W2054797412","https://openalex.org/W2054958816","https://openalex.org/W2056025481","https://openalex.org/W2057613746","https://openalex.org/W2058349042","https://openalex.org/W2058467798","https://openalex.org/W2059058130","https://openalex.org/W2059310590","https://openalex.org/W2060610605","https://openalex.org/W2060971056","https://openalex.org/W2061581290","https://openalex.org/W2061681507","https://openalex.org/W2062148835","https://openalex.org/W2063738372","https://openalex.org/W2064477978","https://openalex.org/W2065286706","https://openalex.org/W2065391976","https://openalex.org/W2065416066","https://openalex.org/W2066002146","https://openalex.org/W2067935544","https://openalex.org/W2068617048","https://openalex.org/W2068904459","https://openalex.org/W2070688122","https://openalex.org/W2070915934","https://openalex.org/W2071318481","https://openalex.org/W2072367309","https://openalex.org/W2072691099","https://openalex.org/W2073860269","https://openalex.org/W2074061123","https://openalex.org/W2074369143","https://openalex.org/W2075385578","https://openalex.org/W2076148352","https://openalex.org/W2078333258","https://openalex.org/W2079279420","https://openalex.org/W2079519119","https://openalex.org/W2079671310","https://openalex.org/W2083060092","https://openalex.org/W2083301995","https://openalex.org/W2084128312","https://openalex.org/W2084679742","https://openalex.org/W2085026965","https://openalex.org/W2085768069","https://openalex.org/W2086837225","https://openalex.org/W2087129491","https://openalex.org/W2088256340","https://openalex.org/W2088955805","https://openalex.org/W2089769736","https://openalex.org/W2089823661","https://openalex.org/W2090004056","https://openalex.org/W2090043895","https://openalex.org/W2090872672","https://openalex.org/W2091194839","https://openalex.org/W2092148083","https://openalex.org/W2092321601","https://openalex.org/W2093072166","https://openalex.org/W2093514926","https://openalex.org/W2098391962","https://openalex.org/W2098694377","https://openalex.org/W2099408092","https://openalex.org/W2100056505","https://openalex.org/W2106235427","https://openalex.org/W2106614406","https://openalex.org/W2108050717","https://openalex.org/W2108809409","https://openalex.org/W2110016065","https://openalex.org/W2110456232","https://openalex.org/W2112256467","https://openalex.org/W2113755074","https://openalex.org/W2116228954","https://openalex.org/W2116865830","https://openalex.org/W2117088111","https://openalex.org/W2118038184","https://openalex.org/W2118069376","https://openalex.org/W2118309627","https://openalex.org/W2118359066","https://openalex.org/W2123483502","https://openalex.org/W2124099961","https://openalex.org/W2124486024","https://openalex.org/W2124682773","https://openalex.org/W2124683806","https://openalex.org/W2127198126","https://openalex.org/W2128312680","https://openalex.org/W2131308810","https://openalex.org/W2131784975","https://openalex.org/W2134128872","https://openalex.org/W2135955567","https://openalex.org/W2138326692","https://openalex.org/W2140845062","https://openalex.org/W2141747781","https://openalex.org/W2141877727","https://openalex.org/W2142955580","https://openalex.org/W2143072133","https://openalex.org/W2143477348","https://openalex.org/W2144874949","https://openalex.org/W2145296723","https://openalex.org/W2145629851","https://openalex.org/W2145935269","https://openalex.org/W2146264275","https://openalex.org/W2146655366","https://openalex.org/W2148923308","https://openalex.org/W2149568171","https://openalex.org/W2151718948","https://openalex.org/W2153060249","https://openalex.org/W2153797761","https://openalex.org/W2155200140","https://openalex.org/W2155572902","https://openalex.org/W2158553737","https://openalex.org/W2162246060","https://openalex.org/W2163438163","https://openalex.org/W2165044614","https://openalex.org/W2166090727","https://openalex.org/W2166740761","https://openalex.org/W2167095271","https://openalex.org/W2167183310","https://openalex.org/W2167614851","https://openalex.org/W2167840036","https://openalex.org/W2168462263","https://openalex.org/W2170281863","https://openalex.org/W2170571810","https://openalex.org/W2171448629","https://openalex.org/W2176759914","https://openalex.org/W2181575857","https://openalex.org/W2194056463","https://openalex.org/W2245199792","https://openalex.org/W2304812151","https://openalex.org/W2337604471","https://openalex.org/W2340522209","https://openalex.org/W2403177503","https://openalex.org/W2406265206","https://openalex.org/W2407977578","https://openalex.org/W2411979696","https://openalex.org/W2412653660","https://openalex.org/W2415617113","https://openalex.org/W2418545556"],"related_works":["https://openalex.org/W2070915934","https://openalex.org/W3213898303","https://openalex.org/W4360951772","https://openalex.org/W2767851849","https://openalex.org/W3095284057","https://openalex.org/W4389465018","https://openalex.org/W6902344466","https://openalex.org/W2810330189","https://openalex.org/W2334851190","https://openalex.org/W2020073898"],"abstract_inverted_index":{"Discovering":[0],"the":[1,8,15,54,63,66,108,114,126,145,151,173,176,199,210,221,235,240,244,258,289,303,312],"rules":[2],"of":[3,21,25,40,57,65,90,110,123,129,147,156,163,201,224,237,246,280,314,330],"connectivity":[4,208],"between":[5,45,141,257],"neurons":[6,91,282,296],"in":[7,14,61,98,107,209,216,234,265,272],"brain":[9,67,111,142],"is":[10,101,263],"a":[11,18,120,134,161,254],"necessary":[12],"step":[13],"path":[16],"to":[17,30,50,103,172,239,288,320],"complete":[19],"understanding":[20],"neural":[22],"function.":[23],"Many":[24],"these":[26],"connections":[27,140,149,185,286,301],"are":[28],"thought":[29],"be":[31,104,213],"exquisitely":[32],"organized":[33],"into":[34],"specific":[35,81,184],"`circuits'":[36],"at":[37,144,311,328],"all":[38],"levels":[39],"analysis:":[41],"from":[42,175,302],"macroscopic":[43],"levels,":[44,52],"broadly":[46],"distributed":[47],"brains":[48],"areas,":[49],"subcellular":[51,196,232,317],"within":[53],"dendritic":[55,154],"trees":[56],"individual":[58,86,148],"neurons.":[59,190],"While":[60],"principle":[62],"components":[64],"could":[68,83,324],"interconnect":[69],"randomly,":[70],"theoretical":[71],"and":[72,87,153,165,180,204,231,260,316,323],"experimental":[73],"work":[74],"suggests":[75],"that":[76,118,170,194,206,262,283,309],"targeted":[77],"connections,":[78],"optimized":[79],"for":[80,137],"functions,":[82],"endow":[84],"both":[85],"large":[88],"networks":[89],"with":[92,186],"unique":[93],"computational":[94],"abilities.":[95],"This":[96],"specificity":[97,197,233,310],"circuit":[99,256],"organization":[100],"likely":[102],"especially":[105],"important":[106],"operations":[109],"areas":[112],"like":[113],"prefrontal":[115],"cortex":[116,181],"(PFC)":[117],"mediate":[119],"diverse":[121],"set":[122],"functions.":[124],"In":[125,220,249],"first":[127],"part":[128,223,273],"this":[130,195,202,225,321],"Thesis,":[131],"I":[132,168,192,227,251,275,306],"describe":[133],"novel":[135],"technique":[136],"mapping":[138],"functional":[139,207],"regions":[143],"level":[146,313,329],"onto":[150],"dendrites":[152],"spines":[155],"PFC":[157,174,189,211,241,259,281],"pyramidal":[158],"cells.":[159],"Using":[160,268],"combination":[162],"optogenetics":[164],"two-photon":[166],"microscopy,":[167],"show":[169,308],"inputs":[171,238],"amygdala,":[177],"thalamus,":[178],"hippocampus,":[179],"each":[182],"make":[183],"layer":[187],"2":[188],"Furthermore,":[191],"demonstrate":[193],"influences":[198],"strength":[200],"connection,":[203],"argue":[205],"may":[212,242],"finely":[214],"tuned":[215],"an":[217],"input-specific":[218],"manner.":[219],"second":[222],"thesis,":[226],"investigate":[228],"how":[229],"synaptic":[230],"targeting":[236,318],"influence":[243,326],"behavior":[245],"larger":[247],"circuits.":[248],"particular,":[250],"focus":[252],"on":[253],"reciprocal":[255],"amygdala":[261,290,304],"involved":[264],"emotional":[266],"control.":[267],"similar":[269],"methods":[270],"as":[271],"one,":[274],"identify":[276],"two":[277],"distinct":[278],"populations":[279],"send":[284],"segregated":[285],"either":[287],"or":[291],"contralateral":[292],"mPFC.":[293],"These":[294],"amygdala-projecting":[295],"receive":[297],"preferentially":[298],"strong":[299],"excitatory":[300],"itself.":[305],"then":[307],"synapses":[315],"contributes":[319],"difference,":[322],"ultimately":[325],"activity":[327],"long-range":[331],"networks.":[332]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
