{"id":"https://openalex.org/W33955680","doi":null,"title":"Bone marrow-derived stem cells as an adjunctive treatment for acute myocardial infarction: a systematic review and meta-analysis.","display_name":"Bone marrow-derived stem cells as an adjunctive treatment for acute myocardial infarction: a systematic review and meta-analysis.","publication_year":2011,"publication_date":"2011-07-01","ids":{"openalex":"https://openalex.org/W33955680","mag":"33955680","pmid":"https://pubmed.ncbi.nlm.nih.gov/21979282"},"language":"en","primary_location":{"id":"pmid:21979282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21979282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Indonesiana","raw_type":"Journal Article"},"parent_works":[],"lineage":["https://openalex.org/W33955680"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038955473","display_name":"Raden Ayu Tuty Kuswardhani","orcid":"https://orcid.org/0000-0002-3940-0605","observed_orcids":["https://orcid.org/0000-0002-3940-0605"]},"institutions":[{"id":"https://openalex.org/I126826664","display_name":"Udayana University","ror":"https://ror.org/035qsg823","country_code":"ID","type":"education","lineage":["https://openalex.org/I126826664"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"R A Tuty Kuswardhani","raw_affiliation_strings":["Department of Geriatric Medicine, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali, Indonesia. tutykuswardhani@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Faculty of Medicine, Udayana University-Sanglah Hospital, Bali, Indonesia. tutykuswardhani@yahoo.com","institution_ids":["https://openalex.org/I126826664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061423366","display_name":"Andreas Soejitno","orcid":"https://orcid.org/0000-0001-6703-8378","observed_orcids":["https://orcid.org/0000-0001-6703-8378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Soejitno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5244,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.58440726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"43","issue":"3","first_page":"168","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7680000066757202},{"id":"https://openalex.org/keywords/left-ventricular-ejection-fraction","display_name":"left ventricular ejection fraction","score":0.9430000185966492},{"id":"https://openalex.org/keywords/left-ventricular-end-systolic-volume","display_name":"left ventricular end-systolic volume","score":0.9729999899864197},{"id":"https://openalex.org/keywords/left-ventricular-end-diastolic-volume","display_name":"left ventricular end-diastolic volume","score":1.0},{"id":"https://openalex.org/keywords/recurrent-myocardial-infarction","display_name":"reinfarction","score":0.8769999742507935},{"id":"https://openalex.org/keywords/heart-failure-readmission","display_name":"heart failure readmission","score":0.9700000286102295},{"id":"https://openalex.org/keywords/all-cause-mortality","display_name":"all-cause mortality","score":0.9190000295639038},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.958196759223938},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8202071189880371},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.714799165725708},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.709733784198761},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6378416419029236},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.607860267162323},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5114954710006714},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.24254626035690308},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0744975209236145},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21979282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21979282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Indonesiana","raw_type":"Journal Article"},{"id":"mag:33955680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21979282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1059833853","https://openalex.org/W1103840912","https://openalex.org/W1494331226","https://openalex.org/W1597142791","https://openalex.org/W1600899541","https://openalex.org/W1631250427","https://openalex.org/W1728174319","https://openalex.org/W1979423827","https://openalex.org/W1979993133","https://openalex.org/W1982179799","https://openalex.org/W2000442546","https://openalex.org/W2003996125","https://openalex.org/W2009485059","https://openalex.org/W2009545124","https://openalex.org/W2014802114","https://openalex.org/W2016823790","https://openalex.org/W2029178175","https://openalex.org/W2031201324","https://openalex.org/W2033890227","https://openalex.org/W2041773259","https://openalex.org/W2057997111","https://openalex.org/W2061187219","https://openalex.org/W2065427776","https://openalex.org/W2069364701","https://openalex.org/W2072022353","https://openalex.org/W2078429787","https://openalex.org/W2081678513","https://openalex.org/W2085972521","https://openalex.org/W2096493223","https://openalex.org/W2097077362","https://openalex.org/W2097834438","https://openalex.org/W2104898886","https://openalex.org/W2111486034","https://openalex.org/W2112792041","https://openalex.org/W2114140981","https://openalex.org/W2115844889","https://openalex.org/W2122059700","https://openalex.org/W2123143802","https://openalex.org/W2123163588","https://openalex.org/W2124181709","https://openalex.org/W2125635123","https://openalex.org/W2143823027","https://openalex.org/W2145233450","https://openalex.org/W2151722542","https://openalex.org/W2164505584","https://openalex.org/W2164755477","https://openalex.org/W2167595513","https://openalex.org/W2171328857","https://openalex.org/W2278660621","https://openalex.org/W2345010225","https://openalex.org/W2373138909","https://openalex.org/W2396690099","https://openalex.org/W2542860684","https://openalex.org/W2554314047","https://openalex.org/W2577448887","https://openalex.org/W2599049309","https://openalex.org/W2619796536","https://openalex.org/W2767170048","https://openalex.org/W2767682362","https://openalex.org/W2792057361","https://openalex.org/W2796886518","https://openalex.org/W2800238839","https://openalex.org/W2914032227","https://openalex.org/W2964252018","https://openalex.org/W2977949433","https://openalex.org/W2990277106","https://openalex.org/W2998176959","https://openalex.org/W3012509420"],"related_works":["https://openalex.org/W2888857379","https://openalex.org/W2406693686","https://openalex.org/W7166123844","https://openalex.org/W1969530887","https://openalex.org/W2047436971","https://openalex.org/W2359253784","https://openalex.org/W2003002932","https://openalex.org/W2140928988","https://openalex.org/W2014970208","https://openalex.org/W4281980154"],"abstract_inverted_index":{"AIM:":[0],"to":[1,17,58,65,99,109,120,133,147,152,159,175,188,203,225,238],"confirm":[2],"the":[3,18,41,48,60,66,207,229,242],"beneficial":[4],"effect":[5],"of":[6,45,50,200,231,244],"BMCs":[7,46,94,140,212],"therapy":[8,95,141,213],"over":[9],"placebo":[10,100,153],"in":[11],"AMI":[12],"patients":[13],"with":[14,145],"inclusion":[15],"only":[16],"randomized":[19],"double":[20],"blind":[21],"placebo-controlled":[22,38],"trials.":[23],"METHODS:":[24],"we":[25],"searched":[26],"multiple":[27],"database":[28],"(MEDLINE,":[29],"CENTRAL,":[30],"CINAHL)":[31],"through":[32],"January":[33],"2011":[34],"for":[35,47,85,181,196],"randomized,":[36],"double-blind,":[37],"trials":[39],"evaluating":[40],"efficacy":[42],"and":[43,72,77,125,179,221,240,247],"safety":[44],"treatment":[49],"AMI.":[51],"We":[52],"subsequently":[53],"performed":[54],"a":[55,197],"random-effect":[56],"meta-analysis":[57,209],"assess":[59],"eligible":[61],"studies":[62],"included":[63],"related":[64],"primary":[67,232],"outcomes":[68,79,193],"(mean":[69],"LVEF,":[70],"LVESV,":[71,220],"LVEDV":[73,126],"changes":[74],"from":[75,138],"baseline)":[76],"secondary":[78],"(all-cause":[80],"mortality,":[81],"recurrent":[82,168,245],"MI,":[83],"rehospitalization":[84,180],"HF).":[86],"RESULTS:":[87],"ten":[88],"RCTs":[89],"(total=906":[90],"patients)":[91],"were":[92,194],"included.":[93],"was":[96],"proven":[97],"superior":[98],"regarding":[101],"mean":[102],"LVEF":[103],"change":[104],"(2.07%;":[105],"95%":[106,116,129,156,172,185],"CI,":[107,117,130,157,173,186],"0.55%":[108],"3.59%;":[110],"[I2=57%;":[111],"p=0.008]),":[112],"LVESV":[113],"(5.52":[114],"mL;":[115,122,128,135],"-7.68":[118],"mL":[119,132],"-3.36":[121],"[I2=16%;":[123],"p<0.00001]),":[124],"(3.08":[127],"-5.57":[131],"-0.58":[134],"[I2=23%,":[136],"p=0.02])":[137],"baseline.":[139],"showed":[142],"no":[143],"difference":[144],"regards":[146],"mortality":[148],"events":[149],"when":[150,223],"compared":[151,224],"(OR":[154,170,183],"1.01;":[155],"0.35":[158],"2.94;":[160],"[I2=0%;":[161,190],"p=0.98]),":[162],"but":[163],"exerts":[164],"protective":[165],"effects":[166],"toward":[167],"MI":[169,246],"0.45;":[171],"0.09":[174],"2.16;":[176],"[I2=8%;":[177],"p=0.32])":[178],"HF":[182],"0.39;":[184],"0.08":[187],"1.85;":[189],"p=0.24]).":[191],"All":[192],"sustained":[195],"long":[198],"period":[199],"time":[201],"(up":[202],"5":[204],"years).":[205],"CONCLUSION:":[206],"resulting":[208],"concluded":[210],"that":[211],"consistently":[214],"improves":[215],"cardiac":[216],"performance":[217],"parameters":[218],"(LVEF,":[219],"LVEDV)":[222],"placebo,":[226],"even":[227],"after":[228],"establishment":[230],"intervention.":[233],"It":[234],"is":[235],"also":[236],"safe":[237],"use":[239],"prevents":[241],"development":[243],"HF.":[248]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}