{"id":"https://openalex.org/W339241222","doi":null,"title":"Cortical Processing of Frequency Modulated Sweeps in a Mouse Model of Presbycusis","display_name":"Cortical Processing of Frequency Modulated Sweeps in a Mouse Model of Presbycusis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W339241222","mag":"339241222"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt86z778ps","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/86z778ps","pdf_url":"https://escholarship.org/uc/item/86z778ps","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/86z778ps","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074502228","display_name":"Michael S. Trujillo","orcid":"https://orcid.org/0000-0001-6939-9388","observed_orcids":["https://orcid.org/0000-0001-6939-9388"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Trujillo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6939-9388","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5074502228"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frequency-modulated-sweeps","display_name":"frequency-modulated sweeps","score":0.9399999976158142},{"id":"https://openalex.org/keywords/auditory-cortex","display_name":"auditory cortex","score":0.9660000205039978},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.7319999933242798},{"id":"https://openalex.org/keywords/direction-selectivity","display_name":"direction selectivity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/auditory-cortex-development","display_name":"auditory cortex development","score":0.31299999356269836},{"id":"https://openalex.org/keywords/auditory-cortex-maturation","display_name":"auditory cortex maturation","score":0.3840000033378601},{"id":"https://openalex.org/keywords/cochlear-hair-cell-loss","display_name":"cochlear hair cell loss","score":0.6359999775886536},{"id":"https://openalex.org/keywords/auditory-processing-deficits","display_name":"auditory processing deficits","score":0.3490000069141388},{"id":"https://openalex.org/keywords/speech-understanding","display_name":"speech understanding","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2779912225","wikidata":"https://www.wikidata.org/wiki/Q1756133","display_name":"Presbycusis","level":3,"score":0.9825038909912109},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.7358707785606384},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.6658616065979004},{"id":"https://openalex.org/C2780297895","wikidata":"https://www.wikidata.org/wiki/Q18676","display_name":"Auditory cortex","level":2,"score":0.6281766891479492},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.5451048016548157},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4876152575016022},{"id":"https://openalex.org/C2776861996","wikidata":"https://www.wikidata.org/wiki/Q241849","display_name":"Sensory processing","level":3,"score":0.478874146938324},{"id":"https://openalex.org/C33612138","wikidata":"https://www.wikidata.org/wiki/Q82654","display_name":"Tonotopy","level":3,"score":0.43626105785369873},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4307522177696228},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4290289282798767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2375342845916748},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt86z778ps","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/86z778ps","pdf_url":"https://escholarship.org/uc/item/86z778ps","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:339241222","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt86z778ps/qt86z778ps.pdf?t=mi3qj9","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt86z778ps","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/86z778ps","pdf_url":"https://escholarship.org/uc/item/86z778ps","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W339241222.pdf","grobid_xml":"https://content.openalex.org/works/W339241222.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W42887599","https://openalex.org/W1530028553","https://openalex.org/W1795411522","https://openalex.org/W1967620797","https://openalex.org/W1976106770","https://openalex.org/W1984402456","https://openalex.org/W1991835766","https://openalex.org/W1991892371","https://openalex.org/W1997628849","https://openalex.org/W2006869880","https://openalex.org/W2008841204","https://openalex.org/W2010849669","https://openalex.org/W2012717802","https://openalex.org/W2013749415","https://openalex.org/W2014944089","https://openalex.org/W2021345058","https://openalex.org/W2024116512","https://openalex.org/W2026740393","https://openalex.org/W2027247649","https://openalex.org/W2031532367","https://openalex.org/W2034696724","https://openalex.org/W2036483999","https://openalex.org/W2045611288","https://openalex.org/W2045733845","https://openalex.org/W2046487969","https://openalex.org/W2048103128","https://openalex.org/W2048549637","https://openalex.org/W2052036764","https://openalex.org/W2053858196","https://openalex.org/W2055808278","https://openalex.org/W2056784894","https://openalex.org/W2056805000","https://openalex.org/W2058811152","https://openalex.org/W2062135637","https://openalex.org/W2062846331","https://openalex.org/W2064414015","https://openalex.org/W2064837683","https://openalex.org/W2069589645","https://openalex.org/W2072274775","https://openalex.org/W2074942478","https://openalex.org/W2076017177","https://openalex.org/W2086699946","https://openalex.org/W2090362587","https://openalex.org/W2092597147","https://openalex.org/W2093282630","https://openalex.org/W2112456820","https://openalex.org/W2114114082","https://openalex.org/W2126617887","https://openalex.org/W2126921619","https://openalex.org/W2127399017","https://openalex.org/W2139731089","https://openalex.org/W2150947848","https://openalex.org/W2152986454","https://openalex.org/W2158084698","https://openalex.org/W2168467995","https://openalex.org/W2169104736","https://openalex.org/W2169509357","https://openalex.org/W2172265909","https://openalex.org/W2271174396","https://openalex.org/W2277829001"],"related_works":["https://openalex.org/W1974436501","https://openalex.org/W3209114785","https://openalex.org/W3133648239","https://openalex.org/W2061383513","https://openalex.org/W2054209424","https://openalex.org/W7098764609","https://openalex.org/W3202656338","https://openalex.org/W2036039853","https://openalex.org/W7098891566","https://openalex.org/W2168819411"],"abstract_inverted_index":{"The":[0,150,205,251,298,310,372,402,428],"population":[1],"over":[2,140],"the":[3,13,22,55,57,75,103,156,165,235,245,255,260,294,302,314,327,341,345,406],"age":[4,28,223,386],"of":[5,21,78,87,106,112,119,128,171,193,203,207,222,228,254,272,313,356,369,405,430],"65":[6],"years":[7],"old":[8,397],"is":[9,19,67,176,266,284,340],"rapidly":[10],"increasing":[11],"around":[12],"world.":[14],"Presbycusis":[15],"(age-related":[16],"hearing":[17,64,80,109,188,198,447],"loss)":[18],"one":[20],"most":[23],"prevalent":[24],"disabilities":[25],"associated":[26],"with":[27,439],"and":[29,34,36,61,82,144,168,278,281,335,382,396,422],"can":[30],"impair":[31],"speech":[32,44],"understanding":[33,45],"social":[35],"emotional":[37],"well-being.":[38],"Deficits":[39],"in":[40,54,124,138,155,178,224,244,326,344,353,366,413],"auditory":[41,249,264,346],"processing,":[42],"including":[43],"are":[46,134],"likely":[47],"caused":[48],"by":[49,190,200],"an":[50],"interaction":[51],"between":[52,384],"changes":[53,71,292],"way":[56],"brain":[58,76],"processes":[59],"sound":[60],"peripheral":[62,79,107],"sensory":[63,108],"loss.":[65,448],"It":[66],"difficult":[68],"to":[69,99,196,211,216],"disambiguate":[70],"that":[72,84,90,136,259,304,318,410],"occur":[73],"within":[74,293],"independent":[77],"loss":[81,110,189,199],"those":[83],"change":[85,137],"because":[86],"it.":[88],"To":[89],"end,":[91],"this":[92,208,282],"dissertation":[93,209],"provides":[94],"a":[95,125,160,220,225,269,295,435],"framework":[96,436],"for":[97,163,268,333,437],"beginning":[98],"tease":[100],"out":[101],"how":[102],"relative":[104],"contributions":[105],"(loss":[111],"cochlear":[113],"hair":[114],"cells)":[115],"on":[116,425],"cortical":[117,213,296],"processing":[118,290],"frequency":[120,139,187],"modulated":[121],"(FM)":[122],"sweeps":[123,133,218],"mouse":[126,157,182,226,263,440],"model":[127,162,227],"presbycusis":[129,411],"(strain":[130],"C57/bl6).":[131],"FM":[132,148,217,238,273,288,306,322,349,362,378,417],"sounds":[135],"time.":[141],"Human":[142],"language":[143],"animal":[145],"vocalizations":[146],"contain":[147],"sweeps.":[149],"genetic":[151,166],"engineering":[152],"tools":[153],"present":[154],"make":[158],"it":[159],"suitable":[161],"probing":[164],"roots":[167],"underlying":[169],"mechanisms":[170,303,320,383],"neural":[172],"dysfunction,":[173],"such":[174],"as":[175,219,434],"seen":[177],"presbycusis.":[179,229],"This":[180],"C57/bl6":[181],"strain":[183],"undergoes":[184,291],"predictable":[185],"high":[186],"6":[191],"months":[192,202],"age,":[194],"continuing":[195],"profound":[197],"12":[201],"age.":[204],"purpose":[206],"was":[210],"establish":[212],"response":[214,240],"properties":[215,241],"function":[221],"Three":[230],"experiments":[231],"were":[232,242,317,409],"performed.":[233],"In":[234],"first":[236,256],"experiment,":[237],"sweep":[239,274,289,307,323,350,363],"profiled":[243],"young":[246,261,328,388],"adult":[247,262,329],"core":[248],"cortex.":[250],"main":[252,311,403],"findings":[253,312,404],"experiment":[257,300,316,374,408],"indicate":[258],"cortex":[265],"selective":[267],"narrow":[270],"range":[271],"rates":[275],"(between":[276],"0.5":[277],"3":[279,391],"kHz/msec)":[280],"selectivity":[283,325,352,365],"depth":[285],"dependent,":[286],"suggesting":[287],"column.":[297],"second":[299,315],"explored":[301],"shape":[305,321],"rate":[308,324,351,364,379,418],"selectivity.":[309],"two":[319],"cortex,":[330,347],"duration":[331],"tuning":[332,360],"tones":[334],"sideband":[336,426],"inhibition.":[337,427],"Sideband":[338],"inhibition":[339],"dominant":[342],"mechanism":[343],"shaping":[348],"approximately":[354,367],"84%":[355],"neurons":[357,370],"tested.":[358,371],"Duration":[359],"shaped":[361],"34%":[368],"third":[373,407],"compared":[375],"direction":[376],"selectivity,":[377,380,415,419],"variability,":[381],"three":[385],"groups,":[387],"(1":[389],"-":[390,399],"months),":[392,395],"middle":[393],"(6-8":[394],"(14":[398],"20":[400],"months).":[401],"results":[412,429],"decreased":[414,423],"slowed":[416],"increased":[420],"variability":[421],"reliance":[424],"these":[431],"studies":[432],"serve":[433],"comparisons":[438],"strains":[441],"who":[442],"do":[443],"not":[444],"experience":[445],"age-related":[446]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
