{"id":"https://openalex.org/W33870042","doi":null,"title":"Free radical metabolism of antiparasitic agents.","display_name":"Free radical metabolism of antiparasitic agents.","publication_year":1986,"publication_date":"1986-09-01","ids":{"openalex":"https://openalex.org/W33870042","mag":"33870042","pmid":"https://pubmed.ncbi.nlm.nih.gov/3017765"},"language":"en","primary_location":{"id":"pmid:3017765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3017765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Federation proceedings","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Docampo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032324284","display_name":"Silvia N.J. Moreno","orcid":"https://orcid.org/0000-0002-2041-6295","observed_orcids":["https://orcid.org/0000-0002-2041-6295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S N Moreno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.6093,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.96830221,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"45","issue":"10","first_page":"2471","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0551999993622303,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-radical-metabolism","display_name":"free radical metabolism","score":0.8080000281333923},{"id":"https://openalex.org/keywords/antiparasitic-drugs","display_name":"antiparasitic drugs","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nitro-compounds","display_name":"nitro compounds","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nifurtimox","display_name":"nifurtimox","score":0.8849999904632568},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.953000009059906},{"id":"https://openalex.org/keywords/benznidazole","display_name":"benznidazole","score":0.9340000152587891},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.996999979019165},{"id":"https://openalex.org/keywords/niridazole","display_name":"niridazole","score":0.8500000238418579},{"id":"https://openalex.org/keywords/5-nitroimidazoles","display_name":"5-nitroimidazoles","score":0.9070000052452087},{"id":"https://openalex.org/keywords/redox-cycling","display_name":"redox cycling","score":0.6380000114440918},{"id":"https://openalex.org/keywords/autooxidation","display_name":"autooxidation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.6209999918937683},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/covalent-attachment","display_name":"covalent binding","score":0.7110000252723694},{"id":"https://openalex.org/keywords/detoxification","display_name":"detoxification","score":0.5490000247955322},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.7229999899864197},{"id":"https://openalex.org/keywords/trichomoniasis","display_name":"trichomoniasis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/giardiasis","display_name":"giardiasis","score":0.8989999890327454},{"id":"https://openalex.org/keywords/balantidiasis","display_name":"balantidiasis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/amoebiasis","display_name":"amoebiasis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":1.0}],"concepts":[{"id":"https://openalex.org/C2776171842","wikidata":"https://www.wikidata.org/wiki/Q425300","display_name":"Benznidazole","level":4,"score":0.8942296504974365},{"id":"https://openalex.org/C2781049234","wikidata":"https://www.wikidata.org/wiki/Q411582","display_name":"Nifurtimox","level":4,"score":0.826499342918396},{"id":"https://openalex.org/C2781421772","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic","level":2,"score":0.7458688616752625},{"id":"https://openalex.org/C2911037157","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic agent","level":2,"score":0.7087697982788086},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6560103297233582},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.5875958204269409},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.5534828901290894},{"id":"https://openalex.org/C2780497538","wikidata":"https://www.wikidata.org/wiki/Q1192006","display_name":"Detoxification (alternative medicine)","level":3,"score":0.532481849193573},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46672263741493225},{"id":"https://openalex.org/C2776635100","wikidata":"https://www.wikidata.org/wiki/Q582559","display_name":"Antiprotozoal","level":3,"score":0.4595325291156769},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.4517322778701782},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.43876686692237854},{"id":"https://openalex.org/C2776955177","wikidata":"https://www.wikidata.org/wiki/Q142698","display_name":"Nitrofuran","level":2,"score":0.4187544882297516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3646043539047241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27441540360450745},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11860072612762451},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1165093183517456},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10059002041816711},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002621","descriptor_name":"Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009547","descriptor_name":"Nifurtimox","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009560","descriptor_name":"Niridazole","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009574","descriptor_name":"Nitro Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009574","descriptor_name":"Nitro Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009593","descriptor_name":"Nitroimidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010272","descriptor_name":"Parasitic Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014318","descriptor_name":"Tritrichomonas","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3017765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3017765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Federation proceedings","raw_type":"Journal Article"},{"id":"mag:33870042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3017765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2131342243"],"related_works":["https://openalex.org/W2054526547","https://openalex.org/W2063979596","https://openalex.org/W1963689126","https://openalex.org/W2031047447","https://openalex.org/W2321540468","https://openalex.org/W2044873877","https://openalex.org/W7028377021","https://openalex.org/W2016292622","https://openalex.org/W1967866945","https://openalex.org/W2170643233"],"abstract_inverted_index":{"In":[0,97],"recent":[1],"years":[2],"it":[3],"has":[4,26],"been":[5,27,65],"apparent":[6],"that":[7,55],"many":[8],"of":[9,32,34,43,71,85,106,112,119,122,135,151],"the":[10,30,41,49,68,83,104,110,120,152],"known":[11],"antiparasitic":[12,73],"drugs":[13],"produce":[14],"free":[15,52],"radicals.":[16],"Intracellular":[17],"reduction":[18,150],"followed":[19],"by":[20,147],"autooxidation":[21],"yielding":[22],"O.-2":[23],"and":[24,39,78,95],"H2O2":[25],"suggested":[28],"as":[29,40,88,100,102],"mode":[31],"action":[33],"nifurtimox":[35],"on":[36],"Trypanosoma":[37],"cruzi":[38],"basis":[42],"its":[44],"toxicity":[45],"in":[46,67,82,103,109,130],"mammals.":[47],"On":[48],"other":[50,72,79,117],"hand,":[51],"radical":[53],"intermediates":[54,121],"do":[56],"not":[57],"generate":[58],"oxygen-reduction":[59],"products":[60],"under":[61,138],"physiological":[62],"conditions":[63,140],"have":[64],"found":[66],"metabolic":[69],"pathways":[70],"nitro":[74],"compounds":[75,137],"(benznidazole,":[76],"metronidazole,":[77],"5-nitroimidazoles)":[80],"used":[81],"treatment":[84,111],"diseases":[86],"such":[87],"Chagas'":[89],"disease,":[90],"trichomoniasis,":[91],"giardiasis,":[92],"balantidiasis,":[93],"amebiasis,":[94],"schistosomiasis.":[96],"these":[98,136],"cases,":[99],"well":[101],"case":[105],"niridazole":[107],"(used":[108],"schistosomiasis),":[113],"covalent":[114],"binding":[115],"or":[116],"interactions":[118],"nitroreduction":[123],"with":[124],"parasite":[125],"macromolecules":[126],"are":[127],"possibly":[128],"involved":[129],"their":[131],"toxicity.":[132],"Redox":[133],"cycling":[134],"aerobic":[139],"appears":[141],"to":[142],"be":[143],"a":[144],"detoxification":[145],"reaction":[146],"inhibiting":[148],"net":[149],"drugs.":[153]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}