{"id":"https://openalex.org/W33845565","doi":null,"title":"Gene expression and genetic engineering in the lens. Friedenwald lecture.","display_name":"Gene expression and genetic engineering in the lens. Friedenwald lecture.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W33845565","mag":"33845565","pmid":"https://pubmed.ncbi.nlm.nih.gov/3026987"},"language":"en","primary_location":{"id":"pmid:3026987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3026987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067297656","display_name":"Joram Piatigorsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J Piatigorsky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067297656"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4791,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89616702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"28","issue":"1","first_page":"9","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.6425999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.16609999537467957,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11291","display_name":"Intraocular Surgery and Lenses","score":0.045499999076128006,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lens","display_name":"lens","score":0.6669999957084656},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.953000009059906},{"id":"https://openalex.org/keywords/genetic-engineering","display_name":"genetic engineering","score":0.9710000157356262},{"id":"https://openalex.org/keywords/crystalline-lens","display_name":"crystalline lens","score":0.6299999952316284},{"id":"https://openalex.org/keywords/ophthalmic-genetics","display_name":"ocular genetics","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.5452629923820496},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.47310757637023926},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43570971488952637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34942930936813354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3179478645324707},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.23226642608642578},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.19175374507904053},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13419410586357117},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000123","descriptor_name":"Acetyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000952","descriptor_name":"Antigens, Polyomavirus Transforming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000957","descriptor_name":"Antigens, Viral, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003461","descriptor_name":"Crystallography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3026987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3026987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:33845565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3026987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W8028680","https://openalex.org/W61912170","https://openalex.org/W132475858","https://openalex.org/W190919892","https://openalex.org/W254561787","https://openalex.org/W267085019","https://openalex.org/W301438226","https://openalex.org/W1416344515","https://openalex.org/W1496644699","https://openalex.org/W1511379322","https://openalex.org/W1511716040","https://openalex.org/W1522550631","https://openalex.org/W1535060211","https://openalex.org/W1552057640","https://openalex.org/W1572187558","https://openalex.org/W1584686445","https://openalex.org/W1586297339","https://openalex.org/W1848344374","https://openalex.org/W1884183593","https://openalex.org/W1957398633","https://openalex.org/W1963875432","https://openalex.org/W1965372133","https://openalex.org/W1966371940","https://openalex.org/W1966648387","https://openalex.org/W1966999260","https://openalex.org/W1968997934","https://openalex.org/W1969915151","https://openalex.org/W1971589484","https://openalex.org/W1978942031","https://openalex.org/W1981057134","https://openalex.org/W1981796510","https://openalex.org/W1981836564","https://openalex.org/W1981997822","https://openalex.org/W1984955764","https://openalex.org/W1986981224","https://openalex.org/W1987458920","https://openalex.org/W1991172675","https://openalex.org/W1993704650","https://openalex.org/W1993847207","https://openalex.org/W1995394417","https://openalex.org/W1996133970","https://openalex.org/W1996804932","https://openalex.org/W1998160383","https://openalex.org/W2000823208","https://openalex.org/W2001107577","https://openalex.org/W2002609010","https://openalex.org/W2005282714","https://openalex.org/W2006295254","https://openalex.org/W2008718743","https://openalex.org/W2012348124","https://openalex.org/W2013939292","https://openalex.org/W2015878392","https://openalex.org/W2016192215","https://openalex.org/W2016470202","https://openalex.org/W2016697658","https://openalex.org/W2020022390","https://openalex.org/W2020422130","https://openalex.org/W2021128616","https://openalex.org/W2022274660","https://openalex.org/W2023679200","https://openalex.org/W2027596020","https://openalex.org/W2031715332","https://openalex.org/W2033065494","https://openalex.org/W2033597620","https://openalex.org/W2034303388","https://openalex.org/W2036042116","https://openalex.org/W2038218774","https://openalex.org/W2044215151","https://openalex.org/W2046383401","https://openalex.org/W2047602106","https://openalex.org/W2048400898","https://openalex.org/W2050858239","https://openalex.org/W2052264293","https://openalex.org/W2053572117","https://openalex.org/W2054199889","https://openalex.org/W2055091962","https://openalex.org/W2056182498","https://openalex.org/W2057073066","https://openalex.org/W2057893650","https://openalex.org/W2058469411","https://openalex.org/W2060193542","https://openalex.org/W2061227947","https://openalex.org/W2065265764","https://openalex.org/W2073273861","https://openalex.org/W2076521338","https://openalex.org/W2086432537","https://openalex.org/W2086501414","https://openalex.org/W2088016975","https://openalex.org/W2088032669","https://openalex.org/W2088167128","https://openalex.org/W2089723533","https://openalex.org/W2091400806","https://openalex.org/W2093524404","https://openalex.org/W2108317548","https://openalex.org/W2126601733","https://openalex.org/W2127496773","https://openalex.org/W2135338236","https://openalex.org/W2144206181","https://openalex.org/W2144881376","https://openalex.org/W2146951815","https://openalex.org/W2193875022","https://openalex.org/W2290166085","https://openalex.org/W2343181233","https://openalex.org/W2409267713","https://openalex.org/W2411813740","https://openalex.org/W2413379033","https://openalex.org/W3013908881","https://openalex.org/W3015197445","https://openalex.org/W3018546675","https://openalex.org/W3019475956","https://openalex.org/W3022970511","https://openalex.org/W3023196487","https://openalex.org/W3023898787","https://openalex.org/W3024580769","https://openalex.org/W3026544498","https://openalex.org/W3028390009","https://openalex.org/W3032607812","https://openalex.org/W3032810375","https://openalex.org/W3032840500","https://openalex.org/W3033025976","https://openalex.org/W3033842779","https://openalex.org/W3034867627","https://openalex.org/W3037072021","https://openalex.org/W3038127715","https://openalex.org/W3040322207","https://openalex.org/W3042014887","https://openalex.org/W3042239856","https://openalex.org/W3047181901","https://openalex.org/W3048209469","https://openalex.org/W3048758853","https://openalex.org/W3048867825","https://openalex.org/W3081735060","https://openalex.org/W3082481576","https://openalex.org/W3082799353","https://openalex.org/W3087229286"],"related_works":["https://openalex.org/W2773011705","https://openalex.org/W1128850927","https://openalex.org/W1167372589","https://openalex.org/W1254430773","https://openalex.org/W1004143289","https://openalex.org/W779883491","https://openalex.org/W1022076484","https://openalex.org/W948982435","https://openalex.org/W2993971628","https://openalex.org/W2994607510"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
