{"id":"https://openalex.org/W338405695","doi":null,"title":"Oxidized low density lipoprotein inhibits inducible nitric oxide synthase, GTP cyclohydrolase I and transforming growth factor beta gene expression in rat macrophages.","display_name":"Oxidized low density lipoprotein inhibits inducible nitric oxide synthase, GTP cyclohydrolase I and transforming growth factor beta gene expression in rat macrophages.","publication_year":1999,"publication_date":"1999-09-01","ids":{"openalex":"https://openalex.org/W338405695","mag":"338405695","pmid":"https://pubmed.ncbi.nlm.nih.gov/10574472"},"language":"en","primary_location":{"id":"pmid:10574472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10574472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082864592","display_name":"J\u00f3zef Dulak","orcid":"https://orcid.org/0000-0001-5687-0839","observed_orcids":["https://orcid.org/0000-0001-5687-0839"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"J Dulak","raw_affiliation_strings":["Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krak\u00f3w, Poland. mbdulak@cyf-kr.edu.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krak\u00f3w, Poland. mbdulak@cyf-kr.edu.pl","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110127373","display_name":"M Polus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Polus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046452976","display_name":"I Guevara","orcid":"https://orcid.org/0000-0001-6084-8626","observed_orcids":["https://orcid.org/0000-0001-6084-8626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Guevara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090237882","display_name":"J. Hartwich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hartwich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037724174","display_name":"Iwona Wybra\u0144ska","orcid":"https://orcid.org/0000-0002-7421-7005","observed_orcids":["https://orcid.org/0000-0002-7421-7005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Wybra\u0144ska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081867985","display_name":"Robert Krzesz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Krzesz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016706277","display_name":"Aldona Dembinska-Kiec","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Dembi\u0144ska-Kie\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2348,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.74962811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"50","issue":"3","first_page":"429","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.06340000033378601,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9399999976158142},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/gtp-cyclohydrolase-i","display_name":"GTP cyclohydrolase I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.968999981880188},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.8209999799728394},{"id":"https://openalex.org/keywords/gene-expression-inhibition","display_name":"gene expression inhibition","score":0.7260000109672546},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7129999995231628},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9739999771118164},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.7507005929946899},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.7219634056091309},{"id":"https://openalex.org/C2775956414","wikidata":"https://www.wikidata.org/wiki/Q1487359","display_name":"GTP cyclohydrolase I","level":5,"score":0.6686535477638245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6132248044013977},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6035690307617188},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5288501977920532},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48714277148246765},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4165249764919281},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.38680213689804077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34210067987442017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2894611358642578},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.26656773686408997},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22961363196372986},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006136","descriptor_name":"GTP Cyclohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10574472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10574472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of physiology and pharmacology : an official journal of the Polish Physiological Society","raw_type":"Journal Article"},{"id":"mag:338405695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10574472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2360244644","https://openalex.org/W985930308","https://openalex.org/W3147393115","https://openalex.org/W3027520643","https://openalex.org/W1971226096","https://openalex.org/W1972353756","https://openalex.org/W1963294845","https://openalex.org/W2474654201","https://openalex.org/W77700549","https://openalex.org/W2167363637"],"abstract_inverted_index":{"Several":[0],"studies":[1,192,234],"have":[2,23],"already":[3],"demonstrated":[4],"that":[5,194],"oxidized-":[6],"LDL":[7],"decreases":[8],"nitric":[9,32],"oxide":[10,33],"(NO)":[11],"generation":[12,29,52,173,197],"by":[13,30,53,59,157,176,198,222],"cytokine-stimulated":[14],"macrophages.":[15],"However,":[16],"the":[17,39,66,75,80,90,95,101,136,184,204,207,223,236],"mechanisms":[18],"of":[19,41,68,77,82,153,162,164,174,183,206,210,225,229],"such":[20],"an":[21],"inhibition":[22,152,182],"not":[24],"been":[25],"yet":[26],"elucidated.":[27],"NO":[28,44,51,196],"inducible":[31],"synthase":[34],"(iNOS)":[35],"is":[36,56],"dependent":[37],"on":[38,79,104],"presence":[40],"cofactors":[42],"for":[43,140,241],"generation,":[45],"tetrathydrobiopterin":[46],"(BH4)":[47],"among":[48],"them.":[49],"The":[50],"these":[54],"cells":[55],"also":[57,189],"regulated":[58],"some":[60],"endogenous":[61,227],"inhibitors,":[62],"like":[63],"TGF-beta.":[64],"Therefore,":[65],"aim":[67],"our":[69,233],"recent":[70],"study":[71],"was":[72,133,179,188],"to":[73],"investigate":[74],"influence":[76],"ox-LDL":[78,102,144,199],"expression":[81,106,132,156,187,209],"iNOS":[83,154,165,212],"and":[84,115,128,166,213],"GTP":[85],"cyclohydrolase":[86],"I":[87,168,215],"(GTP-CH":[88],"I),":[89],"key":[91],"enzyme":[92],"involved":[93],"in":[94,107,121],"BH4":[96],"synthesis":[97],"as":[98,100,238],"well":[99],"effect":[103,218],"TGF-beta":[105,129,237],"rat":[108,177],"macrophages":[109,137,178,201],"stimulated":[110],"with":[111,143],"IFNgamma":[112],"(250":[113],"U/ml)":[114],"LPS":[116],"(500":[117],"ng/ml).":[118],"Macrophages,":[119],"activated":[120],"this":[122,242],"way,":[123],"express":[124],"iNOS,":[125],"GTP-CH":[126,167,214],"I,":[127],"mRNA.":[130],"This":[131,217],"inhibited":[134],"when":[135],"were":[138],"preincubated":[139],"24":[141],"hours":[142],"(100":[145],"microg/ml).":[146],"Quantitative":[147],"PCR":[148],"revealed":[149],"about":[150],"10-fold":[151],"gene":[155,230],"ox-LDL.":[158],"As":[159],"a":[160,239],"consequence":[161],"down-regulation":[163],"genes,":[169],"almost":[170],"3-fold":[171],"diminished":[172,208],"NO2-":[175],"observed.":[180],"An":[181],"TGFbeta":[185],"mRNA":[186],"found.":[190],"Our":[191],"indicate":[193],"decreased":[195],"treated":[200],"may":[202,219],"be":[203,220],"result":[205],"both":[211],"genes.":[216],"mediated":[221],"activity":[224],"certain":[226],"inhibitors":[228],"expression,":[231],"however,":[232],"exclude":[235],"candidate":[240],"activity.":[243]},"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
