{"id":"https://openalex.org/W33814885","doi":null,"title":"Production of thymine glycols in DNA by radiation and chemical carcinogens as detected by a monoclonal antibody.","display_name":"Production of thymine glycols in DNA by radiation and chemical carcinogens as detected by a monoclonal antibody.","publication_year":1987,"publication_date":"1987-06-01","ids":{"openalex":"https://openalex.org/W33814885","mag":"33814885","pmid":"https://pubmed.ncbi.nlm.nih.gov/3477281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149462"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1520834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149462","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066104958","display_name":"Steven A. Leadon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S A Leadon","raw_affiliation_strings":["Division of Biology and Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology and Medicine, Lawrence Berkeley Laboratory, University of California, Berkeley 94720","institution_ids":["https://openalex.org/I148283060","https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066104958"],"corresponding_institution_ids":["https://openalex.org/I148283060","https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":2.5307,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.88510788,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":null,"first_page":"113","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.19580000638961792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymine-glycol","display_name":"thymine glycol","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6579999923706055},{"id":"https://openalex.org/keywords/chemical-carcinogens","display_name":"chemical carcinogens","score":0.8600000143051147},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/monoclonal-antibody-detection","display_name":"monoclonal antibody detection","score":0.7170000076293945},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6489999890327454},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/indirect-dna-damage","display_name":"indirect DNA damage","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2776858809","wikidata":"https://www.wikidata.org/wiki/Q171973","display_name":"Thymine","level":3,"score":0.8650293350219727},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.7720154523849487},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7286996245384216},{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6093838810920715},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5745663642883301},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.509430468082428},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4145743250846863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38877689838409424},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.3266388177871704},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.22357600927352905},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17894509434700012},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013941","descriptor_name":"Thymine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015081","descriptor_name":"2-Naphthylamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015081","descriptor_name":"2-Naphthylamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1520834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:3477281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3477281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of cancer. Supplement","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2149462","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2149462/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer Suppl","raw_type":"Text"},{"id":"mag:33814885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3477281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1520834","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2149462","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W12595362","https://openalex.org/W1606009321","https://openalex.org/W1965368044","https://openalex.org/W1966562381","https://openalex.org/W1967144463","https://openalex.org/W1968861395","https://openalex.org/W1975508610","https://openalex.org/W1980237844","https://openalex.org/W1984353960","https://openalex.org/W1984373476","https://openalex.org/W1988892151","https://openalex.org/W1992717460","https://openalex.org/W2009415712","https://openalex.org/W2017155314","https://openalex.org/W2023998295","https://openalex.org/W2027825341","https://openalex.org/W2038108954","https://openalex.org/W2070570687","https://openalex.org/W2070672695","https://openalex.org/W2080484121","https://openalex.org/W2089820030","https://openalex.org/W2092299362","https://openalex.org/W2113022736","https://openalex.org/W2397373187","https://openalex.org/W2401076721","https://openalex.org/W2436146023","https://openalex.org/W2614442853"],"related_works":["https://openalex.org/W1606009321","https://openalex.org/W2401076721","https://openalex.org/W1992717460","https://openalex.org/W4249728828","https://openalex.org/W2013292325","https://openalex.org/W2136087740","https://openalex.org/W1573285928","https://openalex.org/W2004592672","https://openalex.org/W2405229220","https://openalex.org/W89897701"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,18,46,66,105,137],"understand":[3],"the":[4,20,27,47,106,125,138,156,165],"role":[5],"in":[6,59,85,96,98],"carcinogenesis":[7],"of":[8,31,34,42,54,56,127,131,148,158],"damage":[9],"indirectly":[10],"induced":[11],"by":[12,61,68],"chemical":[13,139,166],"carcinogens,":[14,167],"it":[15],"is":[16],"important":[17],"identify":[19],"primary":[21],"DNA":[22,35,60,97,157],"lesions.":[23],"We":[24,89],"have":[25],"measured":[26],"formation":[28],"and":[29,71,108],"repair":[30],"one":[32],"type":[33],"modification,":[36],"5,6-dihydroxydihydrothymine":[37],"(thymine":[38],"glycol),":[39],"following":[40,135,145,161],"exposure":[41,104,136],"cultured":[43],"human":[44,159],"cells":[45,160],"carcinogens":[48,63,107,140],"N-hydroxy-2-naphthylamine":[49],"or":[50,117,120,170],"benzo(a)pyrene.":[51],"The":[52,129],"efficiency":[53,130],"production":[55,111,134],"thymine":[57,92,132],"glycols":[58,75,93,151],"these":[62],"was":[64,112,141],"compared":[65],"that":[67,91,109,144],"ionizing":[69,168],"radiation":[70,169],"ultraviolet":[72,171],"light.":[73,172],"Thymine":[74,150],"were":[76,94,122,152],"detected":[77],"using":[78],"a":[79,86,99],"monoclonal":[80],"antibody":[81],"against":[82],"this":[83],"product":[84],"sensitive":[87],"immunoassay.":[88],"found":[90],"produced":[95],"dose":[100],"dependent":[101],"manner":[102],"after":[103],"their":[110],"reduced":[113],"if":[114],"either":[115,164],"catalase":[116],"superoxide":[118],"dismutase":[119],"both":[121],"present":[123],"at":[124],"time":[126],"treatment.":[128],"glycol":[133],"greater":[142],"than":[143],"equi-toxic":[146],"doses":[147],"radiation.":[149],"efficiently":[153],"removed":[154],"from":[155],"treatment":[162],"with":[163]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
