{"id":"https://openalex.org/W337737587","doi":null,"title":"Immunolocalization of glutathione-peroxidase (GSH-PO) in human adrenal gland--studies on adrenocortical adenomas associated with primary aldosteronism and Cushing's syndrome.","display_name":"Immunolocalization of glutathione-peroxidase (GSH-PO) in human adrenal gland--studies on adrenocortical adenomas associated with primary aldosteronism and Cushing's syndrome.","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W337737587","mag":"337737587","pmid":"https://pubmed.ncbi.nlm.nih.gov/8797265"},"language":"en","primary_location":{"id":"pmid:8797265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8797265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tokai journal of experimental and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109265049","display_name":"Masanori Murakoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Murakoshi","raw_affiliation_strings":["Safety Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Safety Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038703763","display_name":"R Y Osamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Y Osamura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102765229","display_name":"S. Yoshimura","orcid":"https://orcid.org/0009-0003-9712-3049","observed_orcids":["https://orcid.org/0009-0003-9712-3049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Yoshimura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103124295","display_name":"Kazuhiro Watanabe","orcid":"https://orcid.org/0000-0002-4069-0785","observed_orcids":["https://orcid.org/0000-0002-4069-0785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Watanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"20","issue":"2","first_page":"89","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.03779999911785126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/adrenal-gland","display_name":"adrenal gland","score":0.7559999823570251},{"id":"https://openalex.org/keywords/adrenal-adenoma","display_name":"adrenal adenoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"primary aldosteronism","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adrenal-cortex","display_name":"adrenal cortex","score":0.5889999866485596},{"id":"https://openalex.org/keywords/zona-fasciculata","display_name":"zona fasciculata","score":0.890999972820282},{"id":"https://openalex.org/keywords/zona-reticularis","display_name":"zona reticularis","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9919999837875366},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.921999990940094},{"id":"https://openalex.org/keywords/cortisol-production","display_name":"cortisol production","score":0.9200000166893005},{"id":"https://openalex.org/keywords/aldosterone-biosynthesis","display_name":"aldosterone biosynthesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lipofuscin","display_name":"lipofuscin","score":0.8220000267028809},{"id":"https://openalex.org/keywords/smooth-endoplasmic-reticulum","display_name":"smooth endoplasmic reticulum","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2778736161","wikidata":"https://www.wikidata.org/wiki/Q3301573","display_name":"Zona fasciculata","level":3,"score":0.7867964506149292},{"id":"https://openalex.org/C2777784954","wikidata":"https://www.wikidata.org/wiki/Q3549771","display_name":"Zona reticularis","level":5,"score":0.7669272422790527},{"id":"https://openalex.org/C2780233176","wikidata":"https://www.wikidata.org/wiki/Q1939330","display_name":"Primary aldosteronism","level":3,"score":0.751467764377594},{"id":"https://openalex.org/C2777977426","wikidata":"https://www.wikidata.org/wiki/Q19065","display_name":"Adrenal cortex","level":2,"score":0.6832904815673828},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6700544357299805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6408566832542419},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5556412935256958},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.4161933660507202},{"id":"https://openalex.org/C2778674399","wikidata":"https://www.wikidata.org/wiki/Q4684749","display_name":"Adrenocortical adenoma","level":3,"score":0.412455290555954},{"id":"https://openalex.org/C2780178468","wikidata":"https://www.wikidata.org/wiki/Q3551060","display_name":"Zona glomerulosa","level":4,"score":0.3990175724029541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3569828271865845},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.3564302921295166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3216326832771301},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.2866494953632355},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.24362120032310486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.141008198261261},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.11017411947250366},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.05025249719619751},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.049319684505462646},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D003480","descriptor_name":"Cushing Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006929","descriptor_name":"Hyperaldosteronism","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016253","descriptor_name":"Microscopy, Immunoelectron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8797265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8797265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tokai journal of experimental and clinical medicine","raw_type":"Journal Article"},{"id":"mag:337737587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8797265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2088840939","https://openalex.org/W2073375185","https://openalex.org/W2029008270","https://openalex.org/W2045063687","https://openalex.org/W2322663891","https://openalex.org/W408647682","https://openalex.org/W351246346","https://openalex.org/W2064973870","https://openalex.org/W2517909978","https://openalex.org/W2605930889"],"abstract_inverted_index":{"Immunocytochemical":[0],"localization":[1,217],"of":[2,29,49,151,170,188,218,284],"glutathione-peroxidase":[3],"(GSH-PO)":[4],"in":[5,43,62,68,77,87,116,138,148,185,212,223,244,250],"human":[6],"adrenal":[7,22,37,51],"glands":[8,23],"was":[9,40,58,74,84,105,114,124,164,209],"studied":[10],"on":[11,128],"adrenocortical":[12,97,201,246,253,286],"adenomas":[13],"associated":[14,100,204],"with":[15,101,205],"primary":[16,102],"aldosteronism":[17],"and":[18,47,161,267],"Cushing's":[19,206],"syndrome.":[20],"Normal":[21],"were":[24],"obtained":[25],"from":[26],"non-adenomatous":[27],"regions":[28],"the":[30,35,44,50,96,119,149,152,157,171,181,186,200,226,237,245,251,264,281,285],"same":[31],"surgical":[32],"specimens.":[33],"In":[34,53,95,109,199],"normal":[36,252],"glands,":[38],"GSH-PO":[39,57,73,83,104,113,123,132,163,208,219,269],"immunohistochemically":[41],"localized":[42,59,86,115,210],"zonae":[45],"fasciculata":[46,80],"reticularis":[48,93],"cortex.":[52],"immunoelectron":[54,110],"microscopic":[55,111],"investigations,":[56,112],"not":[60],"only":[61,222],"cytoplasm":[63,117,224],"(cytosol":[64],"GSH-PO)":[65],"but":[66],"also":[67],"mitochondria":[69],"(mitochondrial":[70],"GSH-PO).":[71],"Mitochondrial":[72,122],"mostly":[75],"observed":[76,221],"lipid-depleted":[78,213],"inner":[79],"cells.":[81,94,215,254,288],"Cytosol":[82],"mainly":[85,211],"lipid-laden":[88],"or":[89,107,156,231],"lipofuscin":[90],"granule-laden":[91],"zona":[92],"adenoma":[98,202,247,287],"cells":[99,203,248],"aldosteronism,":[103],"weak":[106],"negative.":[108],"near":[118,225],"lipid":[120,145,182,239],"droplets.":[121],"hardly":[125],"seen.":[126],"Based":[127],"our":[129],"findings,":[130],"cytosol":[131,268],"may":[133,191,270,278],"play":[134],"an":[135],"important":[136,173],"role":[137],"protective":[139],"effects":[140],"against":[141],"cell":[142],"injury":[143],"by":[144],"peroxides":[146],"induced":[147],"process":[150,187],"steroid":[153],"hormone":[154],"synthesis":[155,190],"cellular":[158],"aging":[159],"process,":[160],"mitochondrial":[162,265],"strongly":[165],"suggested":[166],"to":[167,280],"be":[168,192,261,271],"one":[169],"most":[172],"enzymes":[174],"for":[175],"steroidogenesis,":[176],"especially":[177],"cortisol":[178,197],"synthesis.":[179,198],"Furthermore,":[180,255],"peroxidation":[183,240],"rate":[184,241],"aldosterone":[189],"less":[193,243],"than":[194,249],"that":[195,236],"during":[196],"syndrome,":[207],"compact":[214],"Intracellular":[216],"w2s":[220],"well-developed":[227],"smooth":[228],"endoplasmic":[229],"reticulum":[230],"round":[232],"mitochondria.":[233],"This":[234],"suggests":[235],"intramitochondrial":[238],"is":[242],"intramitochondrially":[256],"derived":[257],"free":[258],"radicals":[259],"might":[260],"diffuse":[262],"across":[263],"membrane,":[266],"enhanced":[272],"as":[273],"a":[274],"result.":[275],"These":[276],"findings":[277],"correspond":[279],"functional":[282],"significance":[283]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
