{"id":"https://openalex.org/W337405371","doi":null,"title":"In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units.","display_name":"In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units.","publication_year":1988,"publication_date":"1988-07-01","ids":{"openalex":"https://openalex.org/W337405371","mag":"337405371","pmid":"https://pubmed.ncbi.nlm.nih.gov/2475123"},"language":"en","primary_location":{"id":"pmid:2475123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2475123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors (Oxford, England)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075526056","display_name":"Charles K. Barlowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C K Barlowe","raw_affiliation_strings":["Department of Chemistry, University of Texas, Austin 78712"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Texas, Austin 78712","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016223938","display_name":"Dean R. Appling","orcid":"https://orcid.org/0000-0002-5309-3015","observed_orcids":["https://orcid.org/0000-0002-5309-3015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Appling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3977,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.91032009,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"1","issue":"2","first_page":"171","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/one-carbon-units","display_name":"one-carbon units","score":0.9670000076293945},{"id":"https://openalex.org/keywords/serine-catabolism","display_name":"serine catabolism","score":0.8299999833106995},{"id":"https://openalex.org/keywords/formate-production","display_name":"formate production","score":0.8259999752044678},{"id":"https://openalex.org/keywords/purine-biosynthesis","display_name":"purine biosynthesis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/folate-coenzymes","display_name":"folate coenzymes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.8059318661689758},{"id":"https://openalex.org/C2779943223","wikidata":"https://www.wikidata.org/wiki/Q414157","display_name":"Sarcosine","level":4,"score":0.7778657674789429},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6375064849853516},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6343739032745361},{"id":"https://openalex.org/C2780178953","wikidata":"https://www.wikidata.org/wiki/Q2001841","display_name":"Formate","level":3,"score":0.6288542151451111},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.5746535062789917},{"id":"https://openalex.org/C169586020","wikidata":"https://www.wikidata.org/wiki/Q3780159","display_name":"Purine metabolism","level":3,"score":0.5498549342155457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5479238033294678},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.48320329189300537},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.41740113496780396},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4054611623287201},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3198423385620117},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.15225443243980408},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.14524897933006287},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.052968740463256836}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005561","descriptor_name":"Formates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007042","descriptor_name":"Hypoxanthines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012521","descriptor_name":"Sarcosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013367","descriptor_name":"Submitochondrial Particles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2475123","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2475123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioFactors (Oxford, England)","raw_type":"Journal Article"},{"id":"mag:337405371","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2475123","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1849205351","https://openalex.org/W3975443","https://openalex.org/W2145912883","https://openalex.org/W1979003166","https://openalex.org/W1993562745","https://openalex.org/W7165082188","https://openalex.org/W2112358926","https://openalex.org/W2124796751","https://openalex.org/W2058607775","https://openalex.org/W2007827633"],"abstract_inverted_index":{"We":[0],"present":[1],"in":[2,10,14,21,137,145,153],"vitro":[3],"evidence":[4,149],"for":[5,19,34,135,150],"a":[6,70,87,109],"novel":[7],"intercompartmental":[8],"pathway":[9,142],"which":[11,59,131],"folate-mediated":[12],"reactions":[13,125],"mitochondria":[15,26,44,96,118,134],"generate":[16],"one-carbon":[17,91,121,164],"units":[18],"utilization":[20,136],"cytoplasmic":[22,71,101],"processes.":[23],"Rat":[24],"liver":[25],"are":[27,93],"shown":[28],"to":[29,40,57,78,99,126,147],"contain":[30],"the":[31,47,52,61,81,100,127,138],"enzymatic":[32],"activities":[33],"catabolism":[35],"of":[36,49,55,129,159],"serine":[37,50],"or":[38,51],"sarcosine":[39,56],"produce":[41],"formate.":[42],"Intact":[43],"rapidly":[45],"convert":[46],"3-carbon":[48],"N-methyl":[53],"group":[54],"formate,":[58],"exits":[60,133],"mitochondria.":[62],"Labeled":[63],"formate":[64,130],"is":[65,143],"incorporated":[66],"into":[67,106],"purine":[68,72,102,107],"by":[69,95],"synthesizing":[73,103],"system":[74,89],"only":[75],"after":[76],"activation":[77],"10-formyl-THF":[79,83],"via":[80,123],"ATP-dependent":[82],"synthetase":[84],"reaction.":[85],"In":[86],"coupled":[88],"where":[90],"donors":[92,122],"catabolized":[94],"before":[97],"addition":[98],"system,":[104],"incorporation":[105],"shows":[108],"marked":[110],"dependence":[111],"on":[112],"ATP.":[113],"These":[114],"observations":[115],"demonstrate":[116],"that":[117],"can":[119],"metabolize":[120],"THF-dependent":[124],"level":[128],"then":[132],"cytoplasm.":[139],"The":[140],"proposed":[141],"discussed":[144],"relation":[146],"genetic":[148],"its":[151],"operation":[152],"vivo":[154],"as":[155,157],"well":[156],"compartmentation":[158],"folate":[160],"coenzymes":[161],"and":[162],"their":[163],"units.":[165]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}