{"id":"https://openalex.org/W337120153","doi":null,"title":"Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.","display_name":"Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.","publication_year":1988,"publication_date":"1988-05-01","ids":{"openalex":"https://openalex.org/W337120153","mag":"337120153","pmid":"https://pubmed.ncbi.nlm.nih.gov/3133309","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385189"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385189","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108536925","display_name":"M. L. Neale","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]},{"id":"https://openalex.org/I97429440","display_name":"University of Wales","ror":"https://ror.org/01se4f844","country_code":"GB","type":"education","lineage":["https://openalex.org/I97429440"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M L Neale","raw_affiliation_strings":["Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, U.K","institution_ids":["https://openalex.org/I79510175","https://openalex.org/I97429440"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054988314","display_name":"R. A. Fiera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Fiera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034382115","display_name":"N Matthews","orcid":"https://orcid.org/0000-0002-1419-8674","observed_orcids":["https://orcid.org/0000-0002-1419-8674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Matthews","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.612,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.99266126,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"64","issue":"1","first_page":"81","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.28859999775886536,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.2493000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.05570000037550926,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.949999988079071},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cell-lysis","display_name":"cell lysis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.9470000267028809},{"id":"https://openalex.org/keywords/l929-fibroblasts","display_name":"L929 fibroblasts","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.8370000123977661},{"id":"https://openalex.org/keywords/quinacrine","display_name":"quinacrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-resistance","display_name":"TNF resistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.7689999938011169},{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"lipoxygenase","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2776551241","wikidata":"https://www.wikidata.org/wiki/Q24768001","display_name":"Phospholipase A2","level":3,"score":0.8757922649383545},{"id":"https://openalex.org/C73588182","wikidata":"https://www.wikidata.org/wiki/Q2663023","display_name":"Cytolysis","level":4,"score":0.8529435396194458},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.7492403984069824},{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.7103350162506104},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5592411756515503},{"id":"https://openalex.org/C2776888444","wikidata":"https://www.wikidata.org/wiki/Q7187515","display_name":"Phospholipase A","level":4,"score":0.5492545962333679},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.5167021751403809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4748162031173706},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44917863607406616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40351200103759766},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33222347497940063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32642659544944763},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2679592967033386},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2673224210739136},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23358413577079773},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2200395166873932},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010740","descriptor_name":"Phospholipases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011335","descriptor_name":"Proadifen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011796","descriptor_name":"Quinacrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015772","descriptor_name":"4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1385189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},{"id":"pmid:3133309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3133309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Journal Article"},{"id":"mag:337120153","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3133309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1385189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1385189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1517228555","https://openalex.org/W1963680671","https://openalex.org/W1988667160","https://openalex.org/W1992071813","https://openalex.org/W2007451263","https://openalex.org/W2023033845","https://openalex.org/W2033684442","https://openalex.org/W2040909870","https://openalex.org/W2048540725","https://openalex.org/W2057123987","https://openalex.org/W2080784424","https://openalex.org/W2083726090","https://openalex.org/W2116656764","https://openalex.org/W2165191737"],"related_works":["https://openalex.org/W2416838430","https://openalex.org/W2031882933","https://openalex.org/W2078317160","https://openalex.org/W1590348341","https://openalex.org/W1481594380","https://openalex.org/W1776295853","https://openalex.org/W1583645666","https://openalex.org/W2048005240","https://openalex.org/W2001413354","https://openalex.org/W1978069661"],"abstract_inverted_index":{"Earlier":[0],"studies":[1],"have":[2],"indicated":[3],"a":[4,162],"possible":[5],"role":[6,163],"for":[7,164,169],"arachidonate":[8,30,106,140],"metabolism":[9,31],"in":[10,22,175],"the":[11,27,37,98,123,139,176],"direct":[12,177],"cytolysis":[13,113,178],"of":[14,29,42,81,101,114,122,128,138,179],"tumour":[15,18,45,180],"cells":[16,46,116],"by":[17,47,52,120,136,183],"necrosis":[19],"factor":[20],"(TNF)":[21],"vitro.":[23],"In":[24,89],"this":[25],"study,":[26],"involvement":[28],"has":[32],"been":[33],"investigated":[34],"further":[35],"with":[36],"following":[38],"results:":[39],"(i)":[40],"Cytolysis":[41,132],"human":[43],"U937":[44,62,115],"recombinant":[48],"TNF":[49,70,82,109],"was":[50,87,117,133],"reduced":[51,119],"dexamethasone":[53],"and":[54,63,75,92,125],"quinacrine,":[55],"agents":[56],"which":[57,66,94],"inhibit":[58],"phospholipase":[59,155,165],"A2.":[60],"(ii)":[61],"L929":[64],"cells,":[65],"are":[67,95],"susceptible":[68],"to":[69,97],"cytolysis,":[71],"released":[72],"arachidonic":[73,129,170],"acid":[74,130,171],"its":[76,173],"metabolites":[77,174],"within":[78],"5":[79],"hr":[80],"challenge,":[83],"before":[84],"cell":[85,181],"death":[86],"apparent.":[88],"contrast,":[90],"U937/R":[91],"L929/R,":[93],"resistant":[96],"cytolytic":[99],"effects":[100],"TNF,":[102],"did":[103],"not":[104,118,168],"release":[105],"products":[107],"on":[108],"challenge.":[110],"(iii)":[111],"rTNF":[112],"inhibitors":[121,137],"cyclo-oxygenase":[124],"lipo-oxygenase":[126],"pathways":[127],"metabolism.":[131],"reduced,":[134],"however,":[135],"metabolic":[141],"pathway":[142],"involving":[143],"cytochrome":[144],"P450-dependent":[145],"reductase,":[146],"but":[147,167],"only":[148],"at":[149],"reagent":[150],"concentrations":[151],"that":[152],"also":[153],"inhibited":[154],"A2":[156,166],"activity.":[157],"Overall,":[158],"these":[159],"observations":[160],"indicate":[161],"or":[172],"lines":[182],"TNF.":[184]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
