{"id":"https://openalex.org/W33580557","doi":null,"title":"Localization of HeLa cell tumor-suppressor gene to the long arm of chromosome II.","display_name":"Localization of HeLa cell tumor-suppressor gene to the long arm of chromosome II.","publication_year":1989,"publication_date":"1989-10-01","ids":{"openalex":"https://openalex.org/W33580557","mag":"33580557","pmid":"https://pubmed.ncbi.nlm.nih.gov/2577469","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1683512"},"language":"en","primary_location":{"id":"pmid:2577469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2577469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071767339","display_name":"B C Misra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B C Misra","raw_affiliation_strings":["Division of Hematology-Oncology, Children's Hospital, Los Angeles, CA 90027"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Children's Hospital, Los Angeles, CA 90027","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064974770","display_name":"Eri S. Srivatsan","orcid":"https://orcid.org/0000-0001-5551-8163","observed_orcids":["https://orcid.org/0000-0001-5551-8163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Srivatsan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5503,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.93380114,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"4","first_page":"565","last_page":"77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.09279999881982803,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8119999766349792},{"id":"https://openalex.org/keywords/chromosome-11","display_name":"chromosome 11","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.847000002861023},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.5080000162124634},{"id":"https://openalex.org/keywords/microcell-hybrids","display_name":"microcell hybrids","score":0.7319999933242798},{"id":"https://openalex.org/keywords/somatic-hybrids","display_name":"somatic cell hybrids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chromosome-loss","display_name":"chromosome loss","score":0.4410000145435333},{"id":"https://openalex.org/keywords/tumorigenic-phenotype","display_name":"tumorigenic phenotype","score":0.6050000190734863},{"id":"https://openalex.org/keywords/rflp-analysis","display_name":"RFLP analysis","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7460711002349854},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.596477210521698},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.5839975476264954},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5547036528587341},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5437265038490295},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4893130958080292},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.45764726400375366},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4508688747882843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40842700004577637},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3219932019710541},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.3036424517631531}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005134","descriptor_name":"Eye Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006822","descriptor_name":"Hybrid Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012175","descriptor_name":"Retinoblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2577469","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2577469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of human genetics","raw_type":"Journal Article"},{"id":"mag:33580557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2577469","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W60567553","https://openalex.org/W101106793","https://openalex.org/W209900511","https://openalex.org/W1507543066","https://openalex.org/W1577366889","https://openalex.org/W1810274712","https://openalex.org/W1858680866","https://openalex.org/W1957539018","https://openalex.org/W1965018174","https://openalex.org/W1968843604","https://openalex.org/W1970527727","https://openalex.org/W1974540651","https://openalex.org/W1976875150","https://openalex.org/W1981349887","https://openalex.org/W1982361487","https://openalex.org/W1983185335","https://openalex.org/W1988386661","https://openalex.org/W1989752636","https://openalex.org/W1989976890","https://openalex.org/W1991900790","https://openalex.org/W1993093183","https://openalex.org/W1996465274","https://openalex.org/W1998562271","https://openalex.org/W2000593460","https://openalex.org/W2001918964","https://openalex.org/W2002794756","https://openalex.org/W2003169843","https://openalex.org/W2003254721","https://openalex.org/W2003591846","https://openalex.org/W2003818827","https://openalex.org/W2004486431","https://openalex.org/W2010667599","https://openalex.org/W2014669590","https://openalex.org/W2015512796","https://openalex.org/W2019769423","https://openalex.org/W2025615787","https://openalex.org/W2026853588","https://openalex.org/W2032631136","https://openalex.org/W2032731042","https://openalex.org/W2034440981","https://openalex.org/W2035886871","https://openalex.org/W2036557606","https://openalex.org/W2037749822","https://openalex.org/W2040834490","https://openalex.org/W2041170922","https://openalex.org/W2042458819","https://openalex.org/W2043667001","https://openalex.org/W2044812814","https://openalex.org/W2049043858","https://openalex.org/W2054684040","https://openalex.org/W2058392986","https://openalex.org/W2059200111","https://openalex.org/W2061883989","https://openalex.org/W2066477655","https://openalex.org/W2068354825","https://openalex.org/W2069816292","https://openalex.org/W2073683003","https://openalex.org/W2076980954","https://openalex.org/W2086546259","https://openalex.org/W2087184465","https://openalex.org/W2089991257","https://openalex.org/W2090895449","https://openalex.org/W2092781336","https://openalex.org/W2097292741","https://openalex.org/W2099742439","https://openalex.org/W2103943909","https://openalex.org/W2111900042","https://openalex.org/W2123725650","https://openalex.org/W2136736147","https://openalex.org/W2142150081","https://openalex.org/W2145042526","https://openalex.org/W2148747599","https://openalex.org/W2150069228","https://openalex.org/W2153616262","https://openalex.org/W2267364643","https://openalex.org/W2395027512","https://openalex.org/W2396235370","https://openalex.org/W2408657673","https://openalex.org/W2412672267","https://openalex.org/W2469550498","https://openalex.org/W2742755441","https://openalex.org/W2791709251","https://openalex.org/W4290426034"],"related_works":["https://openalex.org/W2156103592","https://openalex.org/W2142150081","https://openalex.org/W101106793","https://openalex.org/W2412672267","https://openalex.org/W2338679197","https://openalex.org/W7097094198","https://openalex.org/W2159442218","https://openalex.org/W2104714198","https://openalex.org/W1454028666","https://openalex.org/W2058464873"],"abstract_inverted_index":{"Cytogenetic":[0],"and":[1,42,84,152,192],"molecular":[2],"genetic":[3],"analyses":[4],"of":[5,18,25,39,58,73,93,114,124,135,146,161,172,185,189,195,209,222],"human":[6],"intraspecific":[7],"HeLa":[8,95,211],"x":[9],"fibroblast":[10],"hybrids":[11,44,68,88,155],"have":[12,33],"provided":[13],"evidence":[14],"for":[15],"the":[16,29,55,71,91,94,115,125,136,142,147,158,162,169,173,183,186,193,196,203,207,210,217],"presence":[17,184],"a":[19,74,79,99,121,133,179],"tumor-suppressor":[20,60],"gene(s)":[21,204],"on":[22],"chromosome":[23,50,76,127,163,190,223],"11":[24,77,191],"normal":[26,75,126],"cells.":[27],"In":[28],"present":[30],"study,":[31],"we":[32],"carried":[34],"out":[35],"extensive":[36],"RFLP":[37],"analysis":[38,108],"various":[40],"nontumorigenic":[41,116],"tumorigenic":[43,80,150,197],"with":[45],"at":[46,167],"least":[47,168],"50":[48],"different":[49,63],"11-specific":[51],"probes":[52],"to":[53,98,216],"determine":[54],"precise":[56],"location":[57],"this":[59],"gene(s).":[61],"Two":[62],"hybrid":[64,82,117,131],"systems,":[65],"(1)":[66],"microcell":[67,151],"derived":[69,89],"by":[70,90],"transfer":[72],"into":[78],"HeLa-derived":[81],"cell":[83,87,102,118,154,212],"(2)":[85],"somatic":[86,153],"fusion":[92],"(D98OR)":[96],"cells":[97],"retinoblastoma":[100],"(Y79)":[101],"line,":[103],"were":[104],"particularly":[105],"informative.":[106],"The":[107,149],"showed":[109,178],"that":[110,202],"all":[111],"but":[112,139,164],"one":[113],"lines":[119],"contained":[120,132],"complete":[122],"copy":[123],"11.":[128,224],"This":[129],"variant":[130],"segment":[134],"long":[137,187,218],"arm":[138,145,160,188,219],"had":[140,156,165],"lost":[141,166],"entire":[143],"short":[144,159],"chromosome.":[148,174],"retained":[157],"q13-23":[170],"region":[171],"Thus,":[175],"these":[176],"results":[177],"perfect":[180],"correlation":[181],"between":[182],"suppression":[194,208],"phenotype.":[198],"We":[199],"conclude":[200],"therefore":[201],"involved":[205],"in":[206],"tumors":[213],"is":[214],"localized":[215],"(q":[220],"arm)":[221]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
