{"id":"https://openalex.org/W335587689","doi":"https://doi.org/10.1021/acsnano.5b00166","title":"Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin\u2013Polylactide Nanoconjugates for Enhanced Cancer Therapy","display_name":"Targeting Tumor Vasculature with Aptamer-Functionalized Doxorubicin\u2013Polylactide Nanoconjugates for Enhanced Cancer Therapy","publication_year":2015,"publication_date":"2015-05-04","ids":{"openalex":"https://openalex.org/W335587689","doi":"https://doi.org/10.1021/acsnano.5b00166","mag":"335587689","pmid":"https://pubmed.ncbi.nlm.nih.gov/25938427"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.5b00166","doi":"https://doi.org/10.1021/acsnano.5b00166","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5b00166","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/220722","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065125027","display_name":"Li Tang","orcid":"https://orcid.org/0000-0002-6393-982X","observed_orcids":["https://orcid.org/0000-0002-6393-982X","https://orcid.org/0000-0002-6776-1846"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Tang","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047323439","display_name":"Rong Tong","orcid":"https://orcid.org/0000-0002-2034-9272","observed_orcids":["https://orcid.org/0000-0002-2034-9272"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Tong","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075370047","display_name":"Virginia J. Coyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia J. Coyle","raw_affiliation_strings":["\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055769104","display_name":"Qian Yin","orcid":"https://orcid.org/0000-0002-6535-9861","observed_orcids":["https://orcid.org/0000-0002-6535-9861"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Yin","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030545546","display_name":"Holly C. Pondenis","orcid":"https://orcid.org/0000-0003-1708-3570","observed_orcids":["https://orcid.org/0000-0003-1708-3570"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Pondenis","raw_affiliation_strings":["\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","University of Illinois at Urbana Champaign"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077396148","display_name":"Luke B. Borst","orcid":"https://orcid.org/0000-0002-2736-1960","observed_orcids":["https://orcid.org/0000-0002-2736-1960"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke B. Borst","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010902410","display_name":"Jianjun Cheng","orcid":"https://orcid.org/0000-0003-2561-9291","observed_orcids":["https://orcid.org/0000-0003-2561-9291","https://orcid.org/0009-0000-5867-8015"]},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jianjun Cheng","raw_affiliation_strings":["Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","Materials Science and Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population Health and Pathobiology, North Carolina State University, Raleigh, North Carolina 27607, United States","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Materials Science and Engineering","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012219010","display_name":"Timothy M. Fan","orcid":"https://orcid.org/0000-0003-2510-7050","observed_orcids":["https://orcid.org/0000-0003-2510-7050"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy M. Fan","raw_affiliation_strings":["\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","Veterinary Clinical Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020 Department of Material Sciences and Engineering and \u2021 Department of Veterinary Clinical Medicine, University of Illinois at Urbana\u2212Champaign, Urbana, Illinois 61801, United States","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Veterinary Clinical Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010902410","https://openalex.org/A5012219010"],"corresponding_institution_ids":["https://openalex.org/I137902535","https://openalex.org/I157725225"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":4.2138,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95581809,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"5072","last_page":"5081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/polylactic-acid","display_name":"polylactic acid","score":0.8690000176429749},{"id":"https://openalex.org/keywords/nanoconjugates","display_name":"nanoconjugates","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tumor-vasculature-targeting","display_name":"tumor vasculature targeting","score":0.8230000138282776},{"id":"https://openalex.org/keywords/canine-hemangiosarcoma","display_name":"canine hemangiosarcoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tumor-associated-endothelial-cells","display_name":"tumor endothelial cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.7379999756813049},{"id":"https://openalex.org/keywords/intravenous-drug-delivery","display_name":"intravenous drug delivery","score":0.878000020980835},{"id":"https://openalex.org/keywords/cytoreduction","display_name":"cytoreduction","score":0.625},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6159999966621399},{"id":"https://openalex.org/keywords/nanoparticle-uptake","display_name":"nanoparticle uptake","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7049865126609802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6519874334335327},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.613716185092926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5084916353225708},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4865095019340515},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4766281843185425},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4107546806335449},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3848785161972046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3081965744495392},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2858973741531372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18455514311790466},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12733206152915955},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.11334839463233948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10404178500175476},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D043425","descriptor_name":"Glutamate Carboxypeptidase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052157","descriptor_name":"Aptamers, Nucleotide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058726","descriptor_name":"Nanoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D058726","descriptor_name":"Nanoconjugates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D058726","descriptor_name":"Nanoconjugates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/acsnano.5b00166","doi":"https://doi.org/10.1021/acsnano.5b00166","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.5b00166","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},{"id":"pmid:25938427","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25938427","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS nano","raw_type":"Journal Article"},{"id":"pmh:oai:infoscience.epfl.ch:220722","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/220722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:infoscience.tind.io:220722","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/128548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:220722","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/220722","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1025954695","display_name":null,"funder_award_id":"1DP2OD007246-01","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G4606100860","display_name":"Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI M","funder_award_id":"R25CA154015","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G463203351","display_name":"Developing Clinically Applicable, Cancer-Targeting Polymeric Nanoconjugates","funder_award_id":"1dp2od007246-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4778635926","display_name":null,"funder_award_id":"R25-CA154015A","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4848068150","display_name":"Camptothecin-Containing Nanoparticles: Control Over Particle Size, Biodistributio","funder_award_id":"R21CA152627","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1523096697","https://openalex.org/W1558144205","https://openalex.org/W1802218256","https://openalex.org/W1906583407","https://openalex.org/W1963528534","https://openalex.org/W1977316337","https://openalex.org/W1978139448","https://openalex.org/W1979584913","https://openalex.org/W1981199702","https://openalex.org/W1985858988","https://openalex.org/W1993308240","https://openalex.org/W1993363930","https://openalex.org/W2000206516","https://openalex.org/W2002516695","https://openalex.org/W2006165138","https://openalex.org/W2008449196","https://openalex.org/W2011030869","https://openalex.org/W2018920164","https://openalex.org/W2019555018","https://openalex.org/W2021718963","https://openalex.org/W2022414372","https://openalex.org/W2033281188","https://openalex.org/W2041919391","https://openalex.org/W2043282831","https://openalex.org/W2046851174","https://openalex.org/W2054728198","https://openalex.org/W2059281433","https://openalex.org/W2060860123","https://openalex.org/W2071745634","https://openalex.org/W2106497182","https://openalex.org/W2107230180","https://openalex.org/W2107373757","https://openalex.org/W2107481969","https://openalex.org/W2110482491","https://openalex.org/W2114785296","https://openalex.org/W2116672406","https://openalex.org/W2120145250","https://openalex.org/W2120567276","https://openalex.org/W2120919288","https://openalex.org/W2124395350","https://openalex.org/W2127770027","https://openalex.org/W2128175100","https://openalex.org/W2133758413","https://openalex.org/W2143878058","https://openalex.org/W2156969927","https://openalex.org/W2158567574","https://openalex.org/W2160714861","https://openalex.org/W2167844763","https://openalex.org/W2169965478","https://openalex.org/W2170556702","https://openalex.org/W2177067006","https://openalex.org/W2183141883","https://openalex.org/W4211136833"],"related_works":["https://openalex.org/W1996517412","https://openalex.org/W2068959534","https://openalex.org/W2938190556","https://openalex.org/W2783137762","https://openalex.org/W2119443975","https://openalex.org/W4221079355","https://openalex.org/W2109858016","https://openalex.org/W2302415057","https://openalex.org/W3201983156","https://openalex.org/W4386945475"],"abstract_inverted_index":{"An":[0],"A10":[1,75,82,99,117,160,196],"aptamer":[2],"(Apt)-functionalized,":[3],"sub-100":[4],"nm":[5],"doxorubicin-polylactide":[6],"(Doxo-PLA)":[7],"nanoconjugate":[8],"(NC)":[9],"with":[10],"controlled":[11,150],"release":[12,152],"profile":[13,167],"was":[14],"developed":[15],"as":[16,178,223],"an":[17,57],"intravenous":[18,174,193],"therapeutic":[19],"strategy":[20],"to":[21,107],"effectively":[22],"target":[23],"and":[24,55,67,95,111,132,154,201,230],"cytoreduce":[25],"canine":[26],"hemangiosarcoma":[27],"(cHSA),":[28],"a":[29,43,88,126,164,206,224],"naturally":[30],"occurring":[31],"solid":[32],"tumor":[33,60,145],"malignancy":[34],"composed":[35],"solely":[36],"of":[37,42,46,69,90,137,149,183,195,208,226],"tumor-associated":[38,70,122,156,219],"endothelium.":[39],"cHSA":[40],"consists":[41],"pure":[44],"population":[45],"malignant":[47],"endothelial":[48,71,123,140,157,220],"cells":[49,124,141],"expressing":[50],"prostate-specific":[51],"membrane":[52],"antigen":[53],"(PSMA)":[54],"is":[56],"ideal":[58],"comparative":[59],"model":[61],"system":[62],"for":[63],"evaluating":[64],"the":[65,135,143,181],"specificity":[66],"feasibility":[68],"cell":[72,93,158,221,228],"targeting":[73],"by":[74,139,180],"Apt-functionalized":[76],"NC":[77],"(A10":[78],"NC).":[79],"In":[80,188],"vitro,":[81],"NCs":[83,101,110,118,138,162,198],"were":[84],"selectively":[85,119],"internalized":[86],"across":[87],"panel":[89],"PSMA-expressing":[91,121],"cancer":[92],"lines,":[94],"when":[96],"incorporating":[97],"Doxo,":[98],"Doxo-PLA":[100,109,161,197],"exerted":[102,199],"greater":[103,213],"cytotoxic":[104],"effects":[105],"compared":[106],"nonfunctionalized":[108],"free":[112],"Doxo.":[113],"Importantly,":[114],"intravenously":[115],"delivered":[116],"targeted":[120],"at":[125],"cellular":[127],"level":[128],"in":[129,168,176,212,217],"tumor-bearing":[130],"mice":[131],"dramatically":[133],"increased":[134],"uptake":[136],"within":[142,205],"local":[144],"microenvironment.":[146],"By":[147],"virtue":[148],"drug":[151],"kinetics":[153],"selective":[155],"targeting,":[159],"possess":[163],"desirable":[165],"safety":[166],"vivo,":[169],"being":[170],"well-tolerated":[171],"following":[172],"high-dose":[173],"infusion":[175],"mice,":[177,190],"supported":[179],"absence":[182],"any":[184],"histologic":[185],"organ":[186],"toxicity.":[187],"cHSA-implanted":[189],"two":[191],"consecutive":[192],"infusions":[194],"rapid":[200],"substantial":[202],"cytoreductive":[203],"activities":[204],"period":[207],"7":[209],"days,":[210],"resulting":[211],"than":[214],"70%":[215],"reduction":[216],"macroscopic":[218],"burden":[222],"consequence":[225],"enhanced":[227],"death":[229],"necrosis.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
