{"id":"https://openalex.org/W3352122","doi":null,"title":"Function of the p53 gene: choice between life and death.","display_name":"Function of the p53 gene: choice between life and death.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W3352122","mag":"3352122","pmid":"https://pubmed.ncbi.nlm.nih.gov/10702638"},"language":"en","primary_location":{"id":"pmid:10702638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10702638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry. Biokhimiia","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055831992","display_name":"Peter M. Chumakov","orcid":"https://orcid.org/0000-0002-8078-2908","observed_orcids":["https://orcid.org/0000-0002-8078-2908"]},"institutions":[{"id":"https://openalex.org/I100098275","display_name":"Engelhardt Institute of Molecular Biology","ror":"https://ror.org/027hwkg23","country_code":"RU","type":"facility","lineage":["https://openalex.org/I100098275","https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"P M Chumakov","raw_affiliation_strings":["Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia. chumakov@imb.ac.ru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 117984, Russia. chumakov@imb.ac.ru","institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055831992"],"corresponding_institution_ids":["https://openalex.org/I100098275","https://openalex.org/I1313323035"],"apc_list":null,"apc_paid":null,"fwci":0.6932,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.69255215,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"65","issue":"1","first_page":"28","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-gene","display_name":"p53 gene","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7570000290870667},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6660000085830688},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.5109999775886536},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.8521214723587036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6993059515953064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6581426858901978},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.618741512298584},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.577529788017273},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.500582218170166},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.49600228667259216},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46422335505485535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4090481400489807},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.20181629061698914},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1593431830406189}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10702638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10702638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry. Biokhimiia","raw_type":"Journal Article"},{"id":"mag:3352122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10702638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1831428880","https://openalex.org/W1856360008","https://openalex.org/W1860047937","https://openalex.org/W1903324674","https://openalex.org/W1926834804","https://openalex.org/W1978406914","https://openalex.org/W2008435997","https://openalex.org/W2026060163","https://openalex.org/W2047107109","https://openalex.org/W2048141128","https://openalex.org/W2063877452","https://openalex.org/W2070824623","https://openalex.org/W2087450028","https://openalex.org/W2103340147","https://openalex.org/W2111447146","https://openalex.org/W2115290061","https://openalex.org/W2120362365","https://openalex.org/W2145679711","https://openalex.org/W2158107656","https://openalex.org/W2164599433","https://openalex.org/W2168924996","https://openalex.org/W2174418452"],"related_works":["https://openalex.org/W1629453516","https://openalex.org/W2086993177","https://openalex.org/W2042695180","https://openalex.org/W2152670733","https://openalex.org/W2399239620","https://openalex.org/W4253035683","https://openalex.org/W7096444889","https://openalex.org/W3202426758","https://openalex.org/W1986461898","https://openalex.org/W604398527"],"abstract_inverted_index":{"Gene":[0],"p53":[1,39,55,76],"is":[2,32,41],"a":[3,7,24,30,59],"central":[4],"component":[5],"of":[6,23,66,74,82,87,97],"system":[8],"that":[9,34,62],"eliminates":[10],"pathologically":[11],"damaged":[12],"cells":[13,67],"from":[14],"an":[15],"organism.":[16,99],"Multiple":[17],"signal":[18],"pathways":[19],"monitor":[20],"the":[21,46,54,64,75,90,98],"state":[22],"cell":[25,51,93],"and":[26,68,95],"when":[27],"damage":[28,84],"or":[29,49],"fault":[31],"found":[33],"could":[35],"cause":[36],"heritable":[37],"changes,":[38],"protein":[40],"activated":[42],"to":[43],"either":[44],"coordinate":[45],"repair":[47],"process":[48],"induce":[50],"suicide.":[52],"Thus,":[53],"gene":[56,77],"acts":[57],"as":[58],"supreme":[60],"judge":[61],"decides":[63],"fate":[65],"guarantees":[69],"their":[70],"social":[71],"behavior.":[72],"Loss":[73],"results":[78],"in":[79],"uncontrolled":[80],"accumulation":[81],"genetic":[83],"causing":[85],"failure":[86],"control":[88],"by":[89],"organism,":[91],"malignant":[92],"growth,":[94],"death":[96]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
