{"id":"https://openalex.org/W334689496","doi":"https://doi.org/10.1023/a:1016205515959","title":"New approach for preparation of 2,3,7-trisubstituted 3,4-dihydroisoquinolinone libraries on solid phase","display_name":"New approach for preparation of 2,3,7-trisubstituted 3,4-dihydroisoquinolinone libraries on solid phase","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W334689496","doi":"https://doi.org/10.1023/a:1016205515959","mag":"334689496","pmid":"https://pubmed.ncbi.nlm.nih.gov/12197072"},"language":"en","primary_location":{"id":"doi:10.1023/a:1016205515959","doi":"https://doi.org/10.1023/a:1016205515959","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1016205515959","pdf_url":null,"source":{"id":"https://openalex.org/S105791650","display_name":"Molecular Diversity","issn_l":"1381-1991","issn":["1381-1991","1573-501X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Diversity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067147252","display_name":"Yidong Ni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yidong Ni","raw_affiliation_strings":["Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA 921214, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA 921214, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006798993","display_name":"Viktor Krch\u0148\u00e1k","orcid":"https://orcid.org/0000-0001-5688-4069","observed_orcids":["https://orcid.org/0000-0001-5688-4069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viktor Krchnak","raw_affiliation_strings":["Encore International Corporation, 3251 W. Lambert Lane, Tucson, AZ, 85742, U.S.A","Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA, 921214, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encore International Corporation, 3251 W. Lambert Lane, Tucson, AZ, 85742, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA, 921214, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055000647","display_name":"Michal Lebl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Lebl","raw_affiliation_strings":["Spyder Instruments, Inc., 9885 Towne Centre Drive, San Diego, CA, 92121, U.S.A","Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA, 921214, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spyder Instruments, Inc., 9885 Towne Centre Drive, San Diego, CA, 92121, U.S.A","institution_ids":[]},{"raw_affiliation_string":"Trega Biosciences, Inc., 9880 Campus Point Drive, San Diego, CA, 921214, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.2407,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.49215311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"5","issue":"3","first_page":"153","last_page":"161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.5473999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","score":0.42649999260902405,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10817","display_name":"Multicomponent Synthesis of Heterocycles","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solid-phase-synthesis","display_name":"solid-phase synthesis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/combinatorial-libraries","display_name":"combinatorial libraries","score":0.6399999856948853},{"id":"https://openalex.org/keywords/schiff-base","display_name":"Schiff base","score":0.875},{"id":"https://openalex.org/keywords/decarboxylation","display_name":"decarboxylation","score":0.9480000138282776}],"concepts":[{"id":"https://openalex.org/C2780595602","wikidata":"https://www.wikidata.org/wiki/Q898436","display_name":"Decarboxylation","level":3,"score":0.7777281403541565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6293048858642578},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6165929436683655},{"id":"https://openalex.org/C2776469878","wikidata":"https://www.wikidata.org/wiki/Q2026994","display_name":"Solid-phase synthesis","level":3,"score":0.6117763519287109},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.51715487241745},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.42700886726379395},{"id":"https://openalex.org/C2776428424","wikidata":"https://www.wikidata.org/wiki/Q2602701","display_name":"Schiff base","level":2,"score":0.41030001640319824},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.37103939056396484},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3483365774154663},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.10713744163513184},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000812","descriptor_name":"Anhydrides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002264","descriptor_name":"Carboxylic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007546","descriptor_name":"Isoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1016205515959","doi":"https://doi.org/10.1023/a:1016205515959","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1016205515959","pdf_url":null,"source":{"id":"https://openalex.org/S105791650","display_name":"Molecular Diversity","issn_l":"1381-1991","issn":["1381-1991","1573-501X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Diversity","raw_type":"journal-article"},{"id":"pmid:12197072","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12197072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular diversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W159690873","https://openalex.org/W1964139666","https://openalex.org/W2020284940","https://openalex.org/W2033314372","https://openalex.org/W2048572871","https://openalex.org/W2062520309","https://openalex.org/W2077159855","https://openalex.org/W2119909160","https://openalex.org/W2131885006","https://openalex.org/W2332522935","https://openalex.org/W2419201217","https://openalex.org/W2916451683","https://openalex.org/W2918128199","https://openalex.org/W2949305307","https://openalex.org/W2950238768","https://openalex.org/W2951930674","https://openalex.org/W2952507768","https://openalex.org/W2953224545","https://openalex.org/W2953250978","https://openalex.org/W3005243429","https://openalex.org/W4240224761","https://openalex.org/W4285719527","https://openalex.org/W6726163936"],"related_works":["https://openalex.org/W2061160670","https://openalex.org/W1988284276","https://openalex.org/W2952150151","https://openalex.org/W2059586317","https://openalex.org/W2950656663","https://openalex.org/W1980611887","https://openalex.org/W2953002434","https://openalex.org/W2158252137","https://openalex.org/W2950001778","https://openalex.org/W1987477113"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}