{"id":"https://openalex.org/W33436133","doi":null,"title":"Statistical Methods for Analyzing Human Genetic Variation in Diverse Populations.","display_name":"Statistical Methods for Analyzing Human Genetic Variation in Diverse Populations.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W33436133","mag":"33436133"},"language":"en","primary_location":{"id":"mag:33436133","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/96024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/96024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028963399","display_name":"Chaolong Wang","orcid":"https://orcid.org/0000-0003-3945-1012","observed_orcids":["https://orcid.org/0000-0003-3945-1012"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chaolong Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3945-1012","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028963399"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00296144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.10740000009536743,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maximum-likelihood-estimation","display_name":"maximum likelihood estimation","score":0.6010000109672546},{"id":"https://openalex.org/keywords/procrustes-analysis","display_name":"Procrustes analysis","score":0.972000002861023},{"id":"https://openalex.org/keywords/spatial-genetic-structure","display_name":"spatial genetic structure","score":0.5580000281333923},{"id":"https://openalex.org/keywords/human-population-structure","display_name":"human population structure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.625}],"concepts":[{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.6994210481643677},{"id":"https://openalex.org/C40583040","wikidata":"https://www.wikidata.org/wiki/Q1502105","display_name":"Human genetic variation","level":5,"score":0.5721574425697327},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.49747851490974426},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.497456818819046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3732971251010895},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.36549562215805054},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3304612636566162},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3202061057090759},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21543681621551514},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18573901057243347},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.12707623839378357},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.058307647705078125},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.05787995457649231},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:33436133","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/96024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/96024","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/96024","pdf_url":"https://deepblue.lib.umich.edu/bitstreams/dfe42e9d-e134-4e01-8cdd-bbeecd671d9b/download","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"mag:33436133","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/96024","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Deep Blue (University of Michigan)","raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2741884983","display_name":null,"funder_award_id":"R01HG005855","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G4446442847","display_name":"Population genetics for large-scale sequencing studies of diverse populations","funder_award_id":"R01HG005855","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5957414990","display_name":"Population-Genetic Studies for Association Mapping","funder_award_id":"R01GM081441","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W33436133.pdf","grobid_xml":"https://content.openalex.org/works/W33436133.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W29779864","https://openalex.org/W31456746","https://openalex.org/W1528307809","https://openalex.org/W1530461011","https://openalex.org/W1587371751","https://openalex.org/W1791286506","https://openalex.org/W1835223847","https://openalex.org/W1907733689","https://openalex.org/W1966936164","https://openalex.org/W1969761972","https://openalex.org/W1972906909","https://openalex.org/W1973533971","https://openalex.org/W1974611538","https://openalex.org/W1975615947","https://openalex.org/W1977212112","https://openalex.org/W1981638214","https://openalex.org/W1981981738","https://openalex.org/W1984358340","https://openalex.org/W1985192042","https://openalex.org/W1992085420","https://openalex.org/W1997476591","https://openalex.org/W1997722194","https://openalex.org/W2001294676","https://openalex.org/W2002845488","https://openalex.org/W2009934890","https://openalex.org/W2010333320","https://openalex.org/W2010691124","https://openalex.org/W2016716898","https://openalex.org/W2017344012","https://openalex.org/W2018903642","https://openalex.org/W2019249381","https://openalex.org/W2022088394","https://openalex.org/W2025734273","https://openalex.org/W2025759727","https://openalex.org/W2026323344","https://openalex.org/W2031382613","https://openalex.org/W2032618685","https://openalex.org/W2037357509","https://openalex.org/W2037455633","https://openalex.org/W2037763236","https://openalex.org/W2044758663","https://openalex.org/W2047366062","https://openalex.org/W2047550265","https://openalex.org/W2048699035","https://openalex.org/W2051003735","https://openalex.org/W2053733652","https://openalex.org/W2056494169","https://openalex.org/W2058245901","https://openalex.org/W2061941091","https://openalex.org/W2066669827","https://openalex.org/W2068909154","https://openalex.org/W2072706575","https://openalex.org/W2090131138","https://openalex.org/W2094063883","https://openalex.org/W2097174914","https://openalex.org/W2102714321","https://openalex.org/W2102729801","https://openalex.org/W2107916366","https://openalex.org/W2108169091","https://openalex.org/W2108396711","https://openalex.org/W2109917005","https://openalex.org/W2112348586","https://openalex.org/W2113725057","https://openalex.org/W2115852179","https://openalex.org/W2115984494","https://openalex.org/W2116329478","https://openalex.org/W2116782829","https://openalex.org/W2117446594","https://openalex.org/W2119232685","https://openalex.org/W2123638675","https://openalex.org/W2124957657","https://openalex.org/W2126121566","https://openalex.org/W2127864831","https://openalex.org/W2128468605","https://openalex.org/W2130562173","https://openalex.org/W2130799876","https://openalex.org/W2132297696","https://openalex.org/W2132661331","https://openalex.org/W2133356131","https://openalex.org/W2138624008","https://openalex.org/W2139265150","https://openalex.org/W2139353300","https://openalex.org/W2141042406","https://openalex.org/W2141163753","https://openalex.org/W2146932984","https://openalex.org/W2148095347","https://openalex.org/W2149681218","https://openalex.org/W2155085787","https://openalex.org/W2157296800","https://openalex.org/W2157535960","https://openalex.org/W2157752701","https://openalex.org/W2158489424","https://openalex.org/W2165235006","https://openalex.org/W2170328376","https://openalex.org/W2170574599","https://openalex.org/W2170685496","https://openalex.org/W2181961150","https://openalex.org/W2400214930","https://openalex.org/W2741717459","https://openalex.org/W3136389637","https://openalex.org/W3188902609","https://openalex.org/W7095782118"],"related_works":["https://openalex.org/W7097105640","https://openalex.org/W1966936164","https://openalex.org/W7098755393","https://openalex.org/W2025759727","https://openalex.org/W7099903556","https://openalex.org/W2181961150","https://openalex.org/W7099622775","https://openalex.org/W2113725057","https://openalex.org/W2744119277","https://openalex.org/W2163877341"],"abstract_inverted_index":{"The":[0,23,277],"recent":[1,53],"expansion":[2],"of":[3,26,65,82,144,158,187,283,287,312,327],"genetic":[4,15,67,159,198,289,303,314,347],"datasets":[5],"in":[6,33,85,103,178,246,259,266,329],"diverse":[7],"populations":[8,271],"has":[9],"allowed":[10],"researchers":[11],"to":[12,47,60,74,116,141,154,173,207,235,332],"investigate":[13],"human":[14,66,288,313,333],"structure":[16,64,286],"and":[17,37,56,100,127,138,203,210,221,238,256,268,305,336],"evolutionary":[18],"history":[19],"with":[20,214],"unprecedented":[21],"resolution.":[22],"huge":[24],"amount":[25],"data":[27,38,226,304],"also":[28],"poses":[29],"new":[30],"statistical":[31,45,298,339],"challenges,":[32],"both":[34,136,297],"quality":[35],"control":[36],"analysis.":[39],"In":[40,292],"this":[41,108,133,294,318],"dissertation,":[42],"I":[43,70,110,130,148,194,230,249],"develop":[44,71],"methods":[46,59,340],"address":[48,107],"some":[49,142],"challenges":[50],"arising":[51],"from":[52,120,227,317,346],"population-genetic":[54,104],"studies,":[55],"apply":[57],"the":[58,62,184,191,215,241,262,284,309,325],"study":[61,234],"geographic":[63,185,216,285,344],"variation.":[68,160,315,348],"First,":[69],"a":[72,79,112,150,232,280,321],"method":[73,134],"correct":[75],"for":[76,90,300,323,341],"allelic":[77,91],"dropout,":[78],"common":[80],"source":[81],"genotyping":[83],"error":[84],"microsatellite":[86,122],"data.":[87],"Traditional":[88],"solutions":[89],"dropout":[92,118],"often":[93,101,182],"require":[94],"replicate":[95],"genotyping,":[96],"which":[97,181],"is":[98,135,264],"costly":[99],"impossible":[102],"studies.":[105],"To":[106],"problem,":[109],"propose":[111],"maximum":[113],"likelihood":[114],"approach":[115,153],"estimate":[117],"rates":[119],"nonreplicated":[121],"genotypes.":[123],"Based":[124],"on":[125,201,224,308],"simulations":[126],"empirical":[128],"data,":[129],"show":[131],"that":[132,197,251],"accurate":[137],"fairly":[139],"robust":[140],"violations":[143],"model":[145],"assumptions.":[146],"Next,":[147],"introduce":[149],"Procrustes":[151,192,222],"analysis":[152,167,223],"compare":[155,236],"spatial":[156,310],"maps":[157,186],"Multivariate":[161],"techniques,":[162],"such":[163],"as":[164],"principal":[165],"components":[166],"(PCA),":[168],"have":[169,272],"been":[170,273],"widely":[171],"used":[172],"summarize":[174],"population":[175,334],"structure,":[176,335],"typically":[177],"two-dimensional":[179],"maps,":[180],"resemble":[183],"sampling":[188],"locations.":[189],"Using":[190],"approach,":[193],"quantitatively":[195],"demonstrate":[196],"coordinates":[199],"based":[200],"SNPs":[202],"CNVs":[204],"are":[205,211],"similar":[206],"each":[208],"other,":[209],"highly":[212],"concordant":[213],"coordinates.":[217],"Finally,":[218],"applying":[219],"PCA":[220],"SNP":[225],"worldwide":[228],"populations,":[229],"perform":[231],"systematic":[233],"genes":[237,255],"geography":[239,257,328],"across":[240],"globe.":[242],"By":[243],"considering":[244],"examples":[245],"different":[247],"regions,":[248],"find":[250],"significant":[252],"similarity":[253,263],"between":[254],"exists":[258],"general.":[260],"Further,":[261],"highest":[265],"Asia":[267],"once":[269],"isolated":[270],"removed,":[274],"Sub-Saharan":[275],"Africa.":[276],"results":[278],"provide":[279,320],"quantitative":[281],"assessment":[282],"variation":[290],"worldwide.":[291],"summary,":[293],"dissertation":[295,319],"contributes":[296],"tools":[299],"analyzing":[301],"large-scale":[302],"biological":[306],"insights":[307],"patterns":[311],"Results":[316],"basis":[322],"evaluating":[324],"role":[326],"giving":[330],"rise":[331],"can":[337],"facilitate":[338],"inferring":[342],"individual":[343],"origin":[345]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}