{"id":"https://openalex.org/W33406744","doi":null,"title":"Prognostic significance of telomeric repeat length alterations in pathological stage I-IIIA non-small cell lung cancer.","display_name":"Prognostic significance of telomeric repeat length alterations in pathological stage I-IIIA non-small cell lung cancer.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W33406744","mag":"33406744","pmid":"https://pubmed.ncbi.nlm.nih.gov/10928174"},"language":"en","primary_location":{"id":"pmid:10928174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10928174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108266652","display_name":"T. Hirashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133306","display_name":"Osaka Prefectural Government","ror":"https://ror.org/02wymnj87","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210133306"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Hirashima","raw_affiliation_strings":["Second Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Japan","institution_ids":["https://openalex.org/I4210133306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008847664","display_name":"Takefumi Komiya","orcid":"https://orcid.org/0000-0002-6484-2210","observed_orcids":["https://orcid.org/0000-0002-6484-2210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Komiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030283097","display_name":"Takashi Nitta","orcid":"https://orcid.org/0009-0004-3068-0550","observed_orcids":["https://orcid.org/0009-0004-3068-0550","https://orcid.org/0009-0004-5331-2304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Nitta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101461607","display_name":"Yuki Takada","orcid":"https://orcid.org/0000-0002-8359-5024","observed_orcids":["https://orcid.org/0000-0002-8359-5024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Takada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076472026","display_name":"Masamitsu Kobayashi","orcid":"https://orcid.org/0000-0001-8861-1778","observed_orcids":["https://orcid.org/0000-0001-8861-1778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kobayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109985786","display_name":"N Masuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Masuda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111720482","display_name":"K Matui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Matui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Takada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Takada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089475897","display_name":"Masanori Kikui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kikui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030567532","display_name":"T Yasumitu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yasumitu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Ohno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Ohno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648645","display_name":"Kazuhiko Nakagawa","orcid":"https://orcid.org/0000-0003-1284-9776","observed_orcids":["https://orcid.org/0000-0003-1284-9776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nakagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076772805","display_name":"Makoto Fukuoka","orcid":"https://orcid.org/0009-0004-6391-0201","observed_orcids":["https://orcid.org/0009-0004-6391-0201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Fukuoka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"I Kawase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Kawase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4095,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.50152068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"3B","first_page":"2181","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.9150000214576721},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7599999904632568},{"id":"https://openalex.org/keywords/survival-time","display_name":"survival time","score":0.8610000014305115},{"id":"https://openalex.org/keywords/pathological-stage","display_name":"pathological stage","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7798373699188232},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7117712497711182},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6700263619422913},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5966752767562866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5909324884414673},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5207997560501099},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.46981173753738403},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4598385691642761},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4102972447872162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3986096680164337},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23386609554290771},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1015520989894867},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08498230576515198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07802113890647888},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012091","descriptor_name":"Repetitive Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015139","descriptor_name":"Blotting, Southern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10928174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10928174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Comparative Study"},{"id":"mag:33406744","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10928174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W2143617191","https://openalex.org/W2903969014","https://openalex.org/W2154782029","https://openalex.org/W2108754806","https://openalex.org/W2147892951","https://openalex.org/W2007214149","https://openalex.org/W2010833321","https://openalex.org/W2767697869","https://openalex.org/W2888113477","https://openalex.org/W2613749114","https://openalex.org/W2139892111","https://openalex.org/W2135284044","https://openalex.org/W1999726690","https://openalex.org/W2117131844","https://openalex.org/W2939116375","https://openalex.org/W2792246443","https://openalex.org/W2993151786","https://openalex.org/W2045688523","https://openalex.org/W2167422870","https://openalex.org/W2095559416"],"related_works":["https://openalex.org/W2150706619","https://openalex.org/W2071440516","https://openalex.org/W2099553428","https://openalex.org/W2120653250","https://openalex.org/W7097610929","https://openalex.org/W2153396150","https://openalex.org/W4313389225","https://openalex.org/W2302368091","https://openalex.org/W2331040770","https://openalex.org/W1964002176"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,50,59,76,92,113,158],"performed":[3],"to":[4,160],"evaluate":[5],"the":[6,118,138,168],"prognostic":[7],"significance":[8],"of":[9,86,137],"alteration":[10,126,151],"in":[11,14,65,73,89,127,152,165],"telomere":[12,48],"length":[13,69,91,109,129,154],"pathological":[15],"stage":[16],"(p-stage)":[17],"I-IIIA":[18,39],"non-small":[19],"cell":[20],"lung":[21,28],"cancer":[22,25],"(NSCLC).":[23],"Paired":[24],"and":[26,83,100],"normal":[27,74,87,111],"tissues":[29],"were":[30],"obtained":[31],"from":[32],"72":[33,121],"patients":[34],"with":[35,125,145],"histologically":[36],"confirmed":[37],"p-stage":[38,161],"NSCLC.":[40],"Terminal":[41],"restriction":[42],"fragment":[43],"(TRF)":[44],"length,":[45,49],"which":[46],"indicates":[47],"measured":[51],"by":[52,62],"Southern":[53],"blot":[54],"analysis.":[55],"Tumor":[56],"telomerase":[57],"activity":[58,141],"also":[60],"assayed":[61],"non-radioactive":[63],"PCR-ELISA":[64],"55":[66],"patients.":[67],"TRF":[68,90,108,128,153],"(mean":[70,96],"+/-":[71,78],"SD)":[72],"tissue":[75],"6.2":[77],"1.1":[79],"Kb.":[80],"Therefore,":[81],"upper":[82],"lower":[84],"limits":[85],"range":[88,112],"set":[93],"at":[94],"8.4":[95],"+":[97],"2SD)":[98],"Kb":[99],"4.0":[101],"(mean-2SD)":[102],"Kb,":[103],"respectively.":[104],"A":[105],"tumor":[106],"showing":[107],"over":[110],"defined":[114],"as":[115],"positive":[116],"for":[117],"alteration.":[119],"In":[120,148],"patients,":[122],"25":[123],"(34.7%)":[124],"had":[130],"significantly":[131],"shorter":[132],"survival":[133,146],"durations":[134],"than":[135],"those":[136],"others.":[139],"Telomerase":[140],"did":[142],"not":[143],"correlate":[144],"duration.":[147],"multivariate":[149],"analysis,":[150],"(P":[155,162],"=":[156,163],"0.0033)":[157],"second":[159],"0.0004)":[164],"importance":[166],"among":[167],"various":[169],"parameters.":[170]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}