{"id":"https://openalex.org/W33401665","doi":null,"title":"Effects of S-methyl glutathione, S-methyl cysteine, and the concentration of oxidized glutathione on transendothelial fluid transport.","display_name":"Effects of S-methyl glutathione, S-methyl cysteine, and the concentration of oxidized glutathione on transendothelial fluid transport.","publication_year":1980,"publication_date":"1980-06-01","ids":{"openalex":"https://openalex.org/W33401665","mag":"33401665","pmid":"https://pubmed.ncbi.nlm.nih.gov/7380626"},"language":"en","primary_location":{"id":"pmid:7380626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7380626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052649520","display_name":"Ethel I. Anderson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E I Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"D D Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D D Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2257,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.84220033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"6","first_page":"684","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.4629000127315521,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.4629000127315521,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.18199999630451202,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/corneal-endothelium","display_name":"corneal endothelium","score":0.8289999961853027},{"id":"https://openalex.org/keywords/corneal-stromal-thinning","display_name":"corneal stromal thinning","score":0.8199999928474426},{"id":"https://openalex.org/keywords/thiol-disulfide-exchange","display_name":"thiol-disulfide exchange","score":0.9639999866485596},{"id":"https://openalex.org/keywords/corneal-edema","display_name":"corneal edema","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.9417024850845337},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7606065273284912},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.7519721984863281},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.6674197316169739},{"id":"https://openalex.org/C2779179908","wikidata":"https://www.wikidata.org/wiki/Q3324838","display_name":"Glutathione disulfide","level":4,"score":0.5031723380088806},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4143194854259491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3700791001319885},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3441418409347534},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3388238549232483},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1486969292163849},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.050878554582595825}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7380626","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7380626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:33401665","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7380626","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2744435205","https://openalex.org/W1997429842","https://openalex.org/W2325873436","https://openalex.org/W2994797990","https://openalex.org/W2969029982","https://openalex.org/W3015261945","https://openalex.org/W4249946739","https://openalex.org/W3013691083","https://openalex.org/W4251438705","https://openalex.org/W2896597270","https://openalex.org/W2809480000","https://openalex.org/W2891273309","https://openalex.org/W3039521629","https://openalex.org/W2794032158","https://openalex.org/W2796364284","https://openalex.org/W2516822926","https://openalex.org/W2003282533","https://openalex.org/W2343831581","https://openalex.org/W2092549034","https://openalex.org/W2107477321","https://openalex.org/W2051852931","https://openalex.org/W2158061036","https://openalex.org/W2015386663","https://openalex.org/W2138596875","https://openalex.org/W2025161059"],"related_works":["https://openalex.org/W1969708117","https://openalex.org/W98108522","https://openalex.org/W2046460580","https://openalex.org/W2016289622","https://openalex.org/W2058983636","https://openalex.org/W7097223761","https://openalex.org/W81297145","https://openalex.org/W1999779527","https://openalex.org/W2025082768","https://openalex.org/W2088289398"],"abstract_inverted_index":{"Endothelial":[0],"perfusions":[1],"of":[2,12,24,65,76,79,88,99,110],"preswollen":[3],"rabbit":[4],"corneal":[5],"preparations":[6],"with":[7,29,57],"S-methyl":[8,34],"glutathione":[9,32],"at":[10,36,42],"levels":[11,78],"2":[13],"x":[14],"10(-4)M":[15,30,37,91],"and":[16],"10(-3)M":[17],"achieve":[18],"about":[19],"70%":[20],"to":[21,52,71,92],"100%,":[22],"respectively,":[23],"the":[25,45,66,72,86,95,104,108],"stromal":[26,100],"thinning":[27,101],"attained":[28],"oxidized":[31],"(GSSG).":[33],"cysteine":[35],"is":[38,113],"without":[39],"effect":[40,75],"and,":[41],"10(-4)M,":[43],"inhibits":[44],"fluid":[46],"pump.":[47],"The":[48],"results":[49],"are":[50,60],"interpreted":[51],"signify":[53],"that":[54],"thiol-disulfide":[55],"exchanges":[56],"GSSG":[58,80,89],"probably":[59],"not":[61],"an":[62],"obligatory":[63],"part":[64],"endothelial":[67],"pump":[68],"mechanism.":[69],"Contrary":[70],"frequently":[73],"inhibitory":[74],"high":[77],"on":[81],"various":[82],"enzyme":[83],"systems,":[84],"increasing":[85],"concentration":[87],"from":[90],"10(-2)M":[93],"stimulates":[94],"first":[96],"hour":[97],"rate":[98],"33%.":[102],"Neither":[103],"total":[105],"amount":[106],"nor":[107],"duration":[109],"thinning,":[111],"however,":[112],"significantly":[114],"affected.":[115]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}