{"id":"https://openalex.org/W33395299","doi":null,"title":"Tract based spatial statistics of the normal appearing white matter in the general elderly population","display_name":"Tract based spatial statistics of the normal appearing white matter in the general elderly population","publication_year":2008,"publication_date":"2008-08-22","ids":{"openalex":"https://openalex.org/W33395299","mag":"33395299"},"language":"en","primary_location":{"id":"pmh:oai:tudelft.nl:uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","pdf_url":"https://repository.tudelft.nl/file/File_43ab595c-c9bf-4195-8ab9-44c5ffa98cd0","source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.tudelft.nl/file/File_43ab595c-c9bf-4195-8ab9-44c5ffa98cd0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042005913","display_name":"Marius de Groot","orcid":"https://orcid.org/0000-0003-0154-1397","observed_orcids":["https://orcid.org/0000-0003-0154-1397"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Marius de Groot","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0154-1397","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042005913"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tract-based-spatial-statistics","display_name":"tract-based spatial statistics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/normal-appearing-white-matter","display_name":"normal-appearing white matter","score":0.9829999804496765},{"id":"https://openalex.org/keywords/white-matter-integrity","display_name":"white matter integrity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.460999995470047},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7960000038146973},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.8389999866485596},{"id":"https://openalex.org/keywords/white-matter-lesions","display_name":"white matter lesions","score":0.7940000295639038},{"id":"https://openalex.org/keywords/white-matter-atrophy","display_name":"white matter atrophy","score":0.777999997138977},{"id":"https://openalex.org/keywords/brain-registration","display_name":"brain registration","score":0.44999998807907104},{"id":"https://openalex.org/keywords/hierarchical-registration","display_name":"hierarchical registration","score":0.7480000257492065},{"id":"https://openalex.org/keywords/white-matter-lesion-segmentation","display_name":"white matter lesion segmentation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8180000185966492},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7509999871253967},{"id":"https://openalex.org/keywords/imaging-biomarkers","display_name":"imaging biomarkers","score":0.781000018119812},{"id":"https://openalex.org/keywords/lateralization","display_name":"laterality","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.911883533000946},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7721167802810669},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.6399658918380737},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5799272060394287},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.40249258279800415},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3251797556877136},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3212907016277313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2615887522697449},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2542465329170227},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25232234597206116},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12567555904388428},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:tudelft.nl:uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","pdf_url":"https://repository.tudelft.nl/file/File_43ab595c-c9bf-4195-8ab9-44c5ffa98cd0","source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},{"id":"mag:33395299","doi":null,"is_oa":false,"landing_page_url":"http://resolver.tudelft.nl/uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:tudelft.nl:uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","doi":null,"is_oa":true,"landing_page_url":"http://resolver.tudelft.nl/uuid:e89b69d0-6135-46f5-ac98-f7ac6581d0dc","pdf_url":"https://repository.tudelft.nl/file/File_43ab595c-c9bf-4195-8ab9-44c5ffa98cd0","source":{"id":"https://openalex.org/S4306400906","display_name":"Research Repository (Delft University of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98358874","host_organization_name":"Delft University of Technology","host_organization_lineage":["https://openalex.org/I98358874"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321009","display_name":"Erasmus Universiteit Rotterdam","ror":"https://ror.org/057w15z03"},{"id":"https://openalex.org/F4320321687","display_name":"Erasmus Medisch Centrum","ror":"https://ror.org/018906e22"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W33395299.pdf","grobid_xml":"https://content.openalex.org/works/W33395299.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W1518003149","https://openalex.org/W1557554815","https://openalex.org/W1582697909","https://openalex.org/W1622620102","https://openalex.org/W1843611896","https://openalex.org/W1869362176","https://openalex.org/W1963663815","https://openalex.org/W1965730864","https://openalex.org/W1968285450","https://openalex.org/W1969182279","https://openalex.org/W1972609121","https://openalex.org/W1973127790","https://openalex.org/W1978949387","https://openalex.org/W1981027686","https://openalex.org/W1984486655","https://openalex.org/W1989653704","https://openalex.org/W1994972002","https://openalex.org/W1995064441","https://openalex.org/W1996000392","https://openalex.org/W1996189276","https://openalex.org/W1997111256","https://openalex.org/W1998642284","https://openalex.org/W2001469430","https://openalex.org/W2005383416","https://openalex.org/W2006096283","https://openalex.org/W2007146250","https://openalex.org/W2011341420","https://openalex.org/W2012648954","https://openalex.org/W2019161608","https://openalex.org/W2021077321","https://openalex.org/W2022092287","https://openalex.org/W2025047388","https://openalex.org/W2026812901","https://openalex.org/W2028942474","https://openalex.org/W2029334347","https://openalex.org/W2032427905","https://openalex.org/W2035126508","https://openalex.org/W2036091286","https://openalex.org/W2036142047","https://openalex.org/W2036864541","https://openalex.org/W2038568172","https://openalex.org/W2041326101","https://openalex.org/W2045296702","https://openalex.org/W2046557060","https://openalex.org/W2047506486","https://openalex.org/W2054183703","https://openalex.org/W2058486187","https://openalex.org/W2058676477","https://openalex.org/W2062687303","https://openalex.org/W2063001897","https://openalex.org/W2069163567","https://openalex.org/W2069529061","https://openalex.org/W2071881327","https://openalex.org/W2072923434","https://openalex.org/W2079041835","https://openalex.org/W2079228607","https://openalex.org/W2080099880","https://openalex.org/W2082853500","https://openalex.org/W2092014599","https://openalex.org/W2094219604","https://openalex.org/W2104961530","https://openalex.org/W2106485269","https://openalex.org/W2109252993","https://openalex.org/W2110065044","https://openalex.org/W2111036014","https://openalex.org/W2113153317","https://openalex.org/W2113576511","https://openalex.org/W2113853821","https://openalex.org/W2116365403","https://openalex.org/W2116547715","https://openalex.org/W2117073713","https://openalex.org/W2117591375","https://openalex.org/W2118421222","https://openalex.org/W2119848633","https://openalex.org/W2120259577","https://openalex.org/W2122320288","https://openalex.org/W2123672494","https://openalex.org/W2126919482","https://openalex.org/W2127112891","https://openalex.org/W2128106262","https://openalex.org/W2128776571","https://openalex.org/W2129285116","https://openalex.org/W2132131830","https://openalex.org/W2134265534","https://openalex.org/W2134590632","https://openalex.org/W2134610285","https://openalex.org/W2138790588","https://openalex.org/W2139588807","https://openalex.org/W2141796362","https://openalex.org/W2142059961","https://openalex.org/W2143316684","https://openalex.org/W2143895814","https://openalex.org/W2144710097","https://openalex.org/W2145775728","https://openalex.org/W2149479555","https://openalex.org/W2150590579","https://openalex.org/W2150667092","https://openalex.org/W2152559989","https://openalex.org/W2158308713","https://openalex.org/W2161794997","https://openalex.org/W2168136132","https://openalex.org/W2168247374","https://openalex.org/W2168523142","https://openalex.org/W2169498480","https://openalex.org/W2170403940","https://openalex.org/W2170644672","https://openalex.org/W2171051269","https://openalex.org/W2171831801","https://openalex.org/W2274873430","https://openalex.org/W2544894372","https://openalex.org/W3127623214"],"related_works":["https://openalex.org/W4230453621","https://openalex.org/W1998089327","https://openalex.org/W7099105864","https://openalex.org/W2091880671","https://openalex.org/W4401573596","https://openalex.org/W7213350689","https://openalex.org/W4239174906","https://openalex.org/W1993637224","https://openalex.org/W2365822611","https://openalex.org/W2128106262"],"abstract_inverted_index":{"The":[0,194,307,398,411],"role":[1],"of":[2,29,51,73,80,112,121,156,178,205,239,352,355,383,401,413,429],"cerebral":[3,81],"white":[4,32,36,82,115,160,219,227,233,240,263,356,459,471],"matter":[5,37,116,161,234,241,264,344,357,460,472],"in":[6,10,39,76,99,132,148,162,174,262,269,320,358,362,370,441],"intact":[7],"brain":[8,274],"functioning":[9],"older":[11],"age":[12],"is":[13,279,360,449],"increasingly":[14],"being":[15],"recognized.":[16],"Recent":[17],"magnetic":[18],"resonance":[19],"(MR)":[20],"imaging":[21,423],"advances":[22],"enable":[23,313],"to":[24,45,118,150,169,223,257,281,297,304,312,336,450,454],"non-invasively":[25],"quantify":[26],"structural":[27,353],"integrity":[28,38,75,354],"normal":[30,158,217],"appearing":[31,159,218],"matter.":[33,83],"Studies":[34],"into":[35,48,245,422,466],"the":[40,49,70,77,113,157,163,172,175,203,216,246,255,270,285,291,330,338,350,373,381,384,388,395,402,443,467],"general":[41,164],"elderly":[42,165],"population,":[43],"aim":[44],"gain":[46],"insight":[47,465],"pathophysiology":[50],"cognitive":[52],"decline":[53],"and":[54,221,290,333,346,375,387,476,478],"neurodegenerative":[55,430],"diseases":[56,431],"such":[57],"as":[58],"dementia.":[59],"Tract":[60,152],"Based":[61,153],"Spatial":[62,154],"Statistics":[63,155],"(TBSS),":[64],"a":[65,100,110,133,180,206,212,299,323],"novel":[66],"analysis":[67,72],"technique,":[68],"allows":[69],"automated":[71],"microstructural":[74,479],"tract":[78],"centres":[79],"Fractional":[84],"anisotropy":[85,192],"images,":[86],"derived":[87,393,416,481],"from":[88,394,417],"Diffusion":[89],"Tensor":[90],"MR":[91,420],"data":[92],"for":[93,197,266,368,408,426],"every":[94],"subject,":[95],"are":[96,106],"spatially":[97],"normalized":[98],"constrained":[101],"manner.":[102],"Subject":[103],"specific":[104,182,213],"measurements":[105,122],"then":[107],"projected":[108,251],"onto":[109,254],"skeleton":[111,256,259],"common":[114],"structures":[117],"allow":[119,211,298,337],"comparison":[120,318],"between":[123,284,469],"subjects.":[124],"A":[125,341,435],"feasibility":[126],"study":[127,138,181],"using":[128],"TBSS":[129,293],"was":[130,184,200,276,295],"conducted":[131],"small":[134],"subject":[135],"group.":[136],"This":[137,326,365,462],"helped":[139],"identify":[140],"methodological":[141,331],"components":[142],"that":[143,390],"needed":[144],"adaptation":[145],"or":[146,458],"extension":[147],"order":[149,168],"analyse":[151],"population.":[166],"In":[167],"best":[170],"drive":[171],"registration":[173,208],"first":[176,436],"stage":[177],"TBSS,":[179],"template":[183],"established":[185],"by":[186,202],"crosswise":[187],"registering":[188],"all":[189],"subjects'":[190],"fractional":[191],"images.":[193],"time":[195],"required":[196],"this":[198],"operation":[199],"reduced":[201],"adoption":[204],"hierarchical":[207],"scheme.":[209],"To":[210],"focus":[214],"on":[215],"matter,":[220,228],"thus":[222],"exclude":[224],"visibly":[225],"abnormal":[226],"we":[229,250],"used":[230],"an":[231],"existing":[232],"lesion":[235,347,456,474],"segmentation.":[236],"Once":[237],"maps":[238,253],"lesions":[242,265],"were":[243],"transformed":[244,296],"subjects":[247],"native":[248],"space,":[249],"these":[252],"earmark":[258],"voxels":[260],"originating":[261],"subsequent":[267],"exclusion":[268],"statistical":[271],"analysis.":[272,340],"Furthermore,":[273],"masking":[275],"improved,":[277],"laterality":[278],"ascertained":[280],"be":[282,305,392,433,439],"consistent":[283],"different":[286],"image":[287],"processing":[288],"pipelines":[289],"followed":[292],"pipeline":[294],"large":[300],"epidemiological":[301],"cohort":[302],"(N=832)":[303],"processed.":[306],"latter":[308],"modifications":[309],"include":[310],"adaptations":[311,334,374],"nonparametric":[314],"permutation":[315],"based":[316,424],"multiple":[317],"correction":[319],"conjunction":[321],"with":[322,482],"clustering":[324],"approach.":[325],"thesis":[327],"mainly":[328],"addresses":[329],"extensions":[332],"implemented":[335],"proposed":[339],"manuscript":[342],"\"White":[343],"atrophy":[345],"formation":[348,475],"explain":[349],"loss":[351],"aging\"":[359],"included":[361],"Appendix":[363],"2.":[364],"manuscript,":[366],"accepted":[367],"publication":[369],"NeuroImage,":[371],"introduces":[372],"extensions,":[376],"but":[377],"most":[378],"importantly":[379],"describes":[380],"application":[382,400],"developed":[385],"methodology":[386,404],"conclusions":[389],"can":[391,432],"obtained":[396],"results.":[397],"successful":[399],"adapted":[403],"offers":[405],"numerous":[406],"opportunities":[407],"future":[409,447],"research.":[410],"aggregation":[412],"tract-specific":[414],"measures":[415,453],"diffusion":[418,483],"tensor":[419,484],"images":[421],"biomarkers":[425],"early":[427],"diagnosis":[428],"investigated.":[434],"start":[437],"will":[438],"made":[440],"studying":[442],"cingulate":[444],"bundle.":[445],"Another":[446],"direction":[448],"define":[451],"local":[452],"describe":[455],"load":[457],"atrophy.":[461],"would":[463],"yield":[464],"link":[468],"macrostructural":[470],"changes,":[473],"atrophy,":[477],"properties":[480],"MR.":[485]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}