{"id":"https://openalex.org/W333664840","doi":null,"title":"[Expression and significance of B cell-activating factor of TNF family (BAFF) and B cell lymphoma/leukemia-2 (BCL-2) in multiple myeloma].","display_name":"[Expression and significance of B cell-activating factor of TNF family (BAFF) and B cell lymphoma/leukemia-2 (BCL-2) in multiple myeloma].","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W333664840","mag":"333664840","pmid":"https://pubmed.ncbi.nlm.nih.gov/21518495"},"language":"zh","primary_location":{"id":"pmid:21518495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21518495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017342037","display_name":"\u738b\u677e\u6885","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song-Mei Wang","raw_affiliation_strings":["Department of Hematology, Qingdao University Medical College, Qingdao, Shandong Province, China. wangsongmei2008@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Qingdao University Medical College, Qingdao, Shandong Province, China. wangsongmei2008@163.com","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007732533","display_name":"\u5f20\u817e\u9f99","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teng-Long Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032847111","display_name":"\u848b\u7389\u6885","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Mei Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065298822","display_name":"\u5434\u5f18\u82f1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Ying Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082164524","display_name":"\u90dd\u9c81\u6885","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lu-Mei Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003563226","display_name":"\u90a2\u79c0\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiu-Hua Xing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"2","first_page":"395","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/baff","display_name":"BAFF","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bone-marrow-mononuclear-cells","display_name":"bone marrow mononuclear cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.5910000205039978},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.8820000290870667},{"id":"https://openalex.org/keywords/durie-salmon-staging","display_name":"Durie-Salmon staging","score":0.9150000214576721},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5809999704360962},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C170286685","wikidata":"https://www.wikidata.org/wiki/Q409346","display_name":"B-cell activating factor","level":4,"score":0.8805044889450073},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.6500197649002075},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5962774753570557},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.584155797958374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5179087519645691},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.51661616563797},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.49685409665107727},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.44627436995506287},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.43269699811935425},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4235721230506897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37047290802001953},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3590781092643738},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3490716814994812},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3476807177066803},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.34020835161209106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26168549060821533},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.25038671493530273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18827849626541138},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0991801917552948},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053264","descriptor_name":"B-Cell Activating Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053264","descriptor_name":"B-Cell Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21518495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21518495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo shi yan xue ye xue za zhi","raw_type":"English Abstract"},{"id":"mag:333664840","doi":null,"is_oa":false,"landing_page_url":"https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=10092137-201104-201108260055-201108260055-395-398","pdf_url":null,"source":{"id":"https://openalex.org/S4306541720","display_name":"\u4e2d\u56fd\u5b9e\u9a8c\u8840\u6db2\u5b66\u6742\u5fd7","issn_l":"1009-2137","issn":["1009-2137"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u570b\u5be6\u9a57\u8840\u6db2\u5b78\u96dc\u8a8c","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2344161590","https://openalex.org/W2356979287","https://openalex.org/W3151426520","https://openalex.org/W2353726406","https://openalex.org/W2731205692","https://openalex.org/W2993084061","https://openalex.org/W2378610215","https://openalex.org/W2031112746","https://openalex.org/W4417104813","https://openalex.org/W2493416293"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,57,74,81,88,96,127,160,177],"aimed":[3],"to":[4,99,269],"explore":[5],"the":[6,32,59,65,79,85,90,108,125,133,210,220,246,259,276,291],"expression":[7,66,109,134,149,193,211,221,262,277],"of":[8,12,27,34,43,48,51,67,93,111,136,151,194,213,223,257,261,264,279,293],"B":[9,17],"cell-activating":[10],"factor":[11],"TNF":[13],"family":[14],"(BAFF)":[15],"and":[16,31,36,41,53,69,84,113,138,153,168,185,196,203,215,225,231,248,255,266,281],"cell":[18],"lymphoma/leukemia-2":[19],"(BCL-2)":[20],"in":[21,72,116,141,156,165,228,239,253],"bone":[22,46],"marrow":[23,47],"mononuclear":[24,60],"cells":[25,61],"(BMMNC)":[26],"multiple":[28],"myeloma":[29],"(MM)":[30],"significance":[33],"BAFF":[35,68,112,137,152,195,214,224,247,265,280],"BCL-2":[37,70,114,139,154,197,216,226,249,267,282],"for":[38,289],"occurrence,":[39],"development":[40,256],"prognosis":[42,292],"MM.":[44],"The":[45,104,148,192],"40":[49],"cases":[50],"MM":[52,94,117,158,187,233,270,294],"10":[54],"healthy":[55],"persons":[56],"collected,":[58],"(MNC)":[62],"were":[63],"isolated,":[64],"mRNA":[71,115,140,155,198,217,227,268,283],"BMMNC":[73],"detected":[75],"by":[76],"real-time":[77],"PCR;":[78],"plasma":[80],"simultaneously":[82],"collected":[83],"\u03b22-MG":[86,204],"level":[87,110,135,150,263,278],"determined;":[89],"clinical":[91],"staging":[92,102,202],"patients":[95,118,159,169,188,234,240],"performed":[97],"according":[98],"Durie-Salmon":[100],"(D-S)":[101],"criterion.":[103],"results":[105],"indicated":[106],"that":[107,164,209],"increased,":[119],"as":[120],"compared":[121],"with":[122,200],"normal":[123,166],"controls,":[124],"difference":[126,181],"statistical":[128],"significant":[129,180],"(p":[130,173,189],"<":[131,174],"0.05);":[132],"plateau":[142,171,242],"stage":[143,172],"after":[144],"treatment":[145],"obviously":[146],"decreased.":[147],"relapsed/refractory":[157,186,232],"significantly":[161],"higher":[162,236],"than":[163,237],"controls":[167],"reached":[170,241],"0.05),":[175],"there":[176],"no":[178],"statistically":[179],"between":[182],"newly":[183,229],"diagnosed":[184,230],">":[190],"0.05).":[191],"related":[199],"D-S":[201],"level.":[205],"It":[206],"is":[207,272],"concluded":[208],"levels":[212,222],"increase,":[218],"moreover":[219],"are":[235],"those":[238],"stage,":[243],"which":[244,274],"suggest":[245],"may":[250,284],"be":[251,285],"involved":[252],"occurrence":[254],"MM;":[258],"relation":[260],"load":[271],"positive,":[273],"indicates":[275],"a":[286],"new":[287],"indicator":[288],"evaluating":[290],"patients.":[295]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}