{"id":"https://openalex.org/W332953574","doi":"https://doi.org/10.1023/a:1010958121396","title":"In vitro bone marrow granulocyte-macrophage progenitor cultures in the assessment of hematotoxic potential of the new drugs","display_name":"In vitro bone marrow granulocyte-macrophage progenitor cultures in the assessment of hematotoxic potential of the new drugs","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W332953574","doi":"https://doi.org/10.1023/a:1010958121396","mag":"332953574","pmid":"https://pubmed.ncbi.nlm.nih.gov/11499700"},"language":"en","primary_location":{"id":"doi:10.1023/a:1010958121396","doi":"https://doi.org/10.1023/a:1010958121396","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1010958121396","pdf_url":null,"source":{"id":"https://openalex.org/S31257671","display_name":"Cell Biology and Toxicology","issn_l":"0742-2091","issn":["0742-2091","1573-6822"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058562874","display_name":"Giulia Negro","orcid":"https://orcid.org/0000-0002-4000-786X","observed_orcids":["https://orcid.org/0000-0002-4000-786X"]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Dal Negro","raw_affiliation_strings":["GlaxoSmithKline S.p.A., Medicines Research Centre, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline S.p.A., Medicines Research Centre, Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033729887","display_name":"Monica Bonato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128413","display_name":"GlaxoSmithKline (Italy)","ror":"https://ror.org/03fe56089","country_code":"IT","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210128413"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Bonato","raw_affiliation_strings":["GlaxoSmithKline S.p.A., Medicines Research Centre, Verona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GlaxoSmithKline S.p.A., Medicines Research Centre, Verona, Italy","institution_ids":["https://openalex.org/I4210128413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039929500","display_name":"Laura Gribaldo","orcid":"https://orcid.org/0000-0002-0595-0756","observed_orcids":["https://orcid.org/0000-0002-0595-0756"]},"institutions":[{"id":"https://openalex.org/I4210118689","display_name":"Joint Research Centre","ror":"https://ror.org/02qezmz13","country_code":"IT","type":"government","lineage":["https://openalex.org/I1320481043","https://openalex.org/I2800387288","https://openalex.org/I4210118689","https://openalex.org/I4210161702"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Gribaldo","raw_affiliation_strings":["ECVAM, JRC Institute for Health and Consumer Protection, Ispra (Va), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ECVAM, JRC Institute for Health and Consumer Protection, Ispra (Va), Italy","institution_ids":["https://openalex.org/I4210118689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.0296,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.0320442,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"17","issue":"2","first_page":"95","last_page":"105"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.7085000276565552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.10899999737739563,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/granulocyte-macrophage-progenitor-cells","display_name":"granulocyte-macrophage progenitor cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/metabolic-activation","display_name":"metabolic activation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/drug-toxicity-screening","display_name":"drug toxicity testing","score":0.49900001287460327},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6700000166893005},{"id":"https://openalex.org/keywords/metabolites","display_name":"metabolites","score":0.5910000205039978},{"id":"https://openalex.org/keywords/synergistic-and-antagonistic-effects","display_name":"synergistic and antagonistic effects","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7371618747711182},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5556652545928955},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.5410910844802856},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4961467683315277},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.4914311170578003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4785224199295044},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44155755639076233},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4193033277988434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4139215350151062},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41051185131073},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3718295991420746},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3686380386352539},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35585033893585205},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.120289146900177},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1023/a:1010958121396","doi":"https://doi.org/10.1023/a:1010958121396","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1010958121396","pdf_url":null,"source":{"id":"https://openalex.org/S31257671","display_name":"Cell Biology and Toxicology","issn_l":"0742-2091","issn":["0742-2091","1573-6822"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology and Toxicology","raw_type":"journal-article"},{"id":"pmid:11499700","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11499700","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology and toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:publications.jrc.ec.europa.eu:JRC21558","doi":null,"is_oa":false,"landing_page_url":"http://publications.jrc.ec.europa.eu/repository/handle/JRC21558","pdf_url":null,"source":{"id":"https://openalex.org/S4306401126","display_name":"Joint Research Centre (European Commission)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800387288","host_organization_name":"European Commission","host_organization_lineage":["https://openalex.org/I2800387288"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles in Journals"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1506961129","https://openalex.org/W1536613515","https://openalex.org/W1602734765","https://openalex.org/W1759335617","https://openalex.org/W1842901255","https://openalex.org/W1846542962","https://openalex.org/W1939948217","https://openalex.org/W1940576640","https://openalex.org/W1951078273","https://openalex.org/W1968540972","https://openalex.org/W1976048521","https://openalex.org/W1978118850","https://openalex.org/W1981135180","https://openalex.org/W1983150933","https://openalex.org/W1987596112","https://openalex.org/W1990738812","https://openalex.org/W1996394172","https://openalex.org/W1998581418","https://openalex.org/W2002287505","https://openalex.org/W2004537396","https://openalex.org/W2018678473","https://openalex.org/W2018717826","https://openalex.org/W2030613360","https://openalex.org/W2036452348","https://openalex.org/W2041969230","https://openalex.org/W2048857066","https://openalex.org/W2050379081","https://openalex.org/W2051014475","https://openalex.org/W2056950646","https://openalex.org/W2062016024","https://openalex.org/W2067195095","https://openalex.org/W2070224307","https://openalex.org/W2070232848","https://openalex.org/W2075025456","https://openalex.org/W2082200420","https://openalex.org/W2084555301","https://openalex.org/W2086371043","https://openalex.org/W2088560606","https://openalex.org/W2091851069","https://openalex.org/W2095242288","https://openalex.org/W2102891537","https://openalex.org/W2117133853","https://openalex.org/W2153471536","https://openalex.org/W2163891284","https://openalex.org/W2166822294","https://openalex.org/W2170572683","https://openalex.org/W2332806396","https://openalex.org/W2339901706","https://openalex.org/W2395528375","https://openalex.org/W2398344704","https://openalex.org/W2412788451","https://openalex.org/W2413805323","https://openalex.org/W2414356660","https://openalex.org/W2425151690","https://openalex.org/W2462434954","https://openalex.org/W2483382435","https://openalex.org/W2507570631","https://openalex.org/W4229885735","https://openalex.org/W4242069567","https://openalex.org/W4285719527","https://openalex.org/W4290296482","https://openalex.org/W4301514089","https://openalex.org/W6829258348"],"related_works":["https://openalex.org/W2069386759","https://openalex.org/W4229901182","https://openalex.org/W153841356","https://openalex.org/W49145177","https://openalex.org/W2033367628","https://openalex.org/W2090695223","https://openalex.org/W7044025010","https://openalex.org/W31822687","https://openalex.org/W2799882951","https://openalex.org/W2673199285"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
