{"id":"https://openalex.org/W33283530","doi":null,"title":"Prevention of carcinoma of cervix with human papillomavirus vaccine.","display_name":"Prevention of carcinoma of cervix with human papillomavirus vaccine.","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W33283530","mag":"33283530","pmid":"https://pubmed.ncbi.nlm.nih.gov/11876611"},"language":"en","primary_location":{"id":"pmid:11876611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11876611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of cancer","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032654860","display_name":"Satyanarayana Gavarasana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800440370","display_name":"Signature Healthcare Brockton Hospital","ror":"https://ror.org/05p3n0372","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800440370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Gavarasana","raw_affiliation_strings":["Department of Surgery, Brockton Hospital, MA 02402, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Brockton Hospital, MA 02402, USA","institution_ids":["https://openalex.org/I2800440370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050774677","display_name":"R S Kalasapudi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R S Kalasapudi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"T D Rao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T D Rao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"S Thirumala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Thirumala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.226,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.54480121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"2-3","first_page":"57","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13544","display_name":"Women's cancer prevention and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7080000042915344},{"id":"https://openalex.org/keywords/human-papillomavirus-vaccine","display_name":"HPV vaccine","score":0.9480000138282776},{"id":"https://openalex.org/keywords/human-papillomavirus-infection","display_name":"HPV infection","score":0.5419999957084656},{"id":"https://openalex.org/keywords/e6-and-e7-oncoproteins","display_name":"HPV E6 and E7 oncoproteins","score":0.843999981880188},{"id":"https://openalex.org/keywords/p53-inactivation","display_name":"p53 inactivation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/retinoblastoma-gene","display_name":"retinoblastoma gene","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cervical-cancer-prevention","display_name":"cervical cancer prevention","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2777740455","wikidata":"https://www.wikidata.org/wiki/Q666412","display_name":"Cervix","level":3,"score":0.7758052349090576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7013953924179077},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6653827428817749},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5372320413589478},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4921721816062927},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.46809032559394836},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.441814124584198},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44176989793777466},{"id":"https://openalex.org/C2780009117","wikidata":"https://www.wikidata.org/wiki/Q900189","display_name":"HPV vaccines","level":5,"score":0.4201866686344147},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4157181680202484},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41407883167266846},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.4128500819206238},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.3533804714679718},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3487452268600464},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32375288009643555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2792189121246338},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1804048717021942},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11603102087974548}],"mesh":[{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014412","descriptor_name":"Tumor Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D053918","descriptor_name":"Papillomavirus Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:11876611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11876611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of cancer","raw_type":"Journal Article"},{"id":"mag:33283530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11876611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W47611972","https://openalex.org/W139145577","https://openalex.org/W139759064","https://openalex.org/W2395149880","https://openalex.org/W2405972034","https://openalex.org/W2407072238","https://openalex.org/W2409184734","https://openalex.org/W2421867850","https://openalex.org/W4300495948"],"related_works":["https://openalex.org/W2115534100","https://openalex.org/W2093927228","https://openalex.org/W2348091805","https://openalex.org/W2403735588","https://openalex.org/W333543371","https://openalex.org/W6996370880","https://openalex.org/W2985532529","https://openalex.org/W7100351927","https://openalex.org/W2075679064","https://openalex.org/W61756930"],"abstract_inverted_index":{"BACKGROUND:":[0],"Carcinoma":[1],"of":[2,13,24,49,64,98,111,134,141,151,159,162,176,196,200],"cervix":[3,25,65,177],"is":[4,30,56,90,171,185],"the":[5,11,60,125,132],"most":[6],"common":[7],"cancer":[8],"found":[9],"among":[10],"women":[12],"India.":[14],"Though":[15],"cervical":[16,103,126],"cytology":[17],"screening":[18],"was":[19,80],"effective":[20,190],"in":[21,26,33,143],"preventing":[22,139],"carcinoma":[23,48,63,175],"developed":[27],"nations,":[28],"it":[29,170],"considered":[31],"unsuitable":[32],"developing":[34],"countries.":[35],"Recent":[36],"research":[37,184],"has":[38],"established":[39],"an":[40,54],"etiological":[41],"link":[42],"between":[43],"human":[44,70,99,179],"papillomavirus":[45,71,100,180],"infection":[46],"and":[47,78,83,109,115,120,136,153,191,198],"cervix.":[50,164],"In":[51],"this":[52],"review,":[53],"attempt":[55],"made":[57],"to":[58,94,173,187],"answer":[59],"question,":[61],"'whether":[62],"can":[66],"be":[67],"prevented":[68],"with":[69,102,146,178],"vaccine?'":[72],"METHODS:":[73],"Literature":[74],"search":[75],"using":[76],"Pubmed":[77],"Medline":[79],"carried":[81],"out":[82],"relevant":[84],"articles":[85],"were":[86],"reviewed.":[87],"RESULTS:":[88],"There":[89],"ample":[91],"experimental":[92,168],"evidence":[93],"show":[95],"that":[96],"DNA":[97],"integrates":[101],"cell":[104],"genome.":[105],"Viral":[106],"genes":[107,138,150],"E6":[108,135,152],"E7":[110,137,154],"HPV":[112,156,193],"type":[113],"16":[114],"18":[116],"inactivate":[117],"p53":[118],"function":[119,133],"Rb":[121],"gene,":[122],"thus":[123],"immortalize":[124],"epithelial":[127],"cells.":[128],"Recombinant":[129],"vaccines":[130],"blocked":[131],"development":[140],"papillomas":[142],"animals.":[144],"Vaccination":[145],"HPV-VLPs":[147],"encoding":[148],"for":[149],"neutralizes":[155],"integrated":[157],"genome":[158],"malignant":[160],"cells":[161],"uterine":[163],"CONCLUSIONS:":[165],"Based":[166],"on":[167],"evidence,":[169],"possible":[172],"prevent":[174],"vaccine,":[181,194],"IMPLICATIONS:":[182],"Further":[183],"necessary":[186],"identify":[188],"a":[189],"safe":[192],"routes":[195],"administration":[197],"characteristics":[199],"potential":[201],"beneficiaries.":[202]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}