{"id":"https://openalex.org/W332608630","doi":null,"title":"Behavior and intelligence in children with the 22q11.2-deletion syndrome","display_name":"Behavior and intelligence in children with the 22q11.2-deletion syndrome","publication_year":2015,"publication_date":"2015-02-02","ids":{"openalex":"https://openalex.org/W332608630","mag":"332608630"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/305694","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/305694","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/305694","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035432827","display_name":"Petra Klaassen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Petra Klaassen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5035432827"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11015","display_name":"Down syndrome and intellectual disability research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/22q11-2-deletion-syndrome","display_name":"22q11.2 deletion syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"intellectual disability","score":0.5479999780654907},{"id":"https://openalex.org/keywords/intelligence-decline","display_name":"intelligence decline","score":0.7070000171661377},{"id":"https://openalex.org/keywords/behavioral-phenotypes","display_name":"behavioral phenotypes","score":0.7850000262260437},{"id":"https://openalex.org/keywords/social-problems","display_name":"social problems","score":0.8389999866485596},{"id":"https://openalex.org/keywords/withdrawal-behavior","display_name":"withdrawal behavior","score":0.6980000138282776},{"id":"https://openalex.org/keywords/psychosis-risk","display_name":"psychosis risk","score":0.9330000281333923},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.675000011920929},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2992572678","wikidata":"https://www.wikidata.org/wiki/Q16918398","display_name":"Deletion syndrome","level":4,"score":0.7451767921447754},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.682506799697876},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5511453151702881},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4988405704498291},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4913281500339508},{"id":"https://openalex.org/C166047926","wikidata":"https://www.wikidata.org/wiki/Q170277","display_name":"Intelligence quotient","level":3,"score":0.47608888149261475},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3887293040752411},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.37827426195144653},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.36048007011413574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3171446919441223},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.21591141819953918},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11184141039848328},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.10517165064811707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08264321088790894},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/305694","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/305694","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/305694","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/305694","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/305694","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/305694","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:332608630","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/305694/Klaassen.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/305694","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/305694","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W18052369","https://openalex.org/W43183854","https://openalex.org/W170834222","https://openalex.org/W1897609813","https://openalex.org/W1968442381","https://openalex.org/W1970759648","https://openalex.org/W1984576581","https://openalex.org/W1999115255","https://openalex.org/W2008954066","https://openalex.org/W2012643850","https://openalex.org/W2029065669","https://openalex.org/W2033447318","https://openalex.org/W2037284285","https://openalex.org/W2038648070","https://openalex.org/W2045116979","https://openalex.org/W2045831576","https://openalex.org/W2049088224","https://openalex.org/W2049643291","https://openalex.org/W2053864873","https://openalex.org/W2054236226","https://openalex.org/W2062525878","https://openalex.org/W2065531744","https://openalex.org/W2074369357","https://openalex.org/W2076786417","https://openalex.org/W2077270977","https://openalex.org/W2079229845","https://openalex.org/W2079529339","https://openalex.org/W2090370087","https://openalex.org/W2095406825","https://openalex.org/W2098050386","https://openalex.org/W2098498763","https://openalex.org/W2099235089","https://openalex.org/W2115533766","https://openalex.org/W2128405990","https://openalex.org/W2143481531","https://openalex.org/W2156691676","https://openalex.org/W2158370744","https://openalex.org/W2167573353","https://openalex.org/W2333030995"],"related_works":["https://openalex.org/W2079229845","https://openalex.org/W2074369357","https://openalex.org/W1968442381","https://openalex.org/W2148452775","https://openalex.org/W2141012240","https://openalex.org/W1841106647","https://openalex.org/W2124212695","https://openalex.org/W2037535091","https://openalex.org/W2327409110","https://openalex.org/W2045831576"],"abstract_inverted_index":{"The":[0],"22q11":[1],"deletion":[2],"syndrome":[3,25,130],"(22q11DS)":[4],"is":[5,51,73,90,123],"a":[6,27,79,115],"genetic":[7],"disorder":[8],"with":[9,23,53,59,94,128],"an":[10],"estimated":[11],"prevalence":[12],"of":[13,70,76,110],"1":[14],"in":[15,45,57,82,105,120],"4000":[16],"live":[17],"births.":[18],"We":[19],"found":[20],"that":[21,74,92,114,126],"children":[22,58,77,93,127],"the":[24,46,111],"have":[26,40],"distinctive":[28],"behavioral":[29,55],"phenotype,":[30],"characterized":[31],"by":[32,137],"social":[33],"problems":[34],"and":[35,87,134],"withdrawn":[36],"behavior.":[37],"They":[38],"also":[39],"lower":[41,49],"mean":[42],"intelligence.":[43],"Although":[44],"general":[47],"population,":[48],"intelligence":[50,83],"associated":[52],"more":[54],"problems,":[56],"22q11DS":[60,95],"no":[61],"such":[62],"relationship":[63],"can":[64],"be":[65,108],"found.":[66],"Another":[67],"remarkable":[68],"result":[69],"our":[71],"study":[72],"42%":[75],"shows":[78],"significant":[80],"decline":[81,104],"between":[84],"ages":[85],"7\u00bd":[86],"15\u00bd.":[88],"It":[89,122],"known":[91],"are":[96],"at":[97],"high":[98],"risk":[99],"for":[100],"developing":[101],"psychosis.":[102],"This":[103],"IQ":[106],"could":[107],"one":[109],"first":[112],"signs":[113],"psychosis":[116],"might":[117],"develop":[118],"later":[119],"life.":[121],"therefore":[124],"recommended":[125],"this":[129],"get":[131],"early":[132],"treatment":[133],"regular":[135],"follow-up":[136],"specialized":[138],"teams.":[139]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}