{"id":"https://openalex.org/W33249657","doi":"https://doi.org/10.1023/a:1016641530206","title":"Expression of the human insulin gene in the gastric G cells of transgenic mice","display_name":"Expression of the human insulin gene in the gastric G cells of transgenic mice","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W33249657","doi":"https://doi.org/10.1023/a:1016641530206","mag":"33249657","pmid":"https://pubmed.ncbi.nlm.nih.gov/11592712"},"language":"en","primary_location":{"id":"doi:10.1023/a:1016641530206","doi":"https://doi.org/10.1023/a:1016641530206","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1016641530206","pdf_url":null,"source":{"id":"https://openalex.org/S190862277","display_name":"Transgenic Research","issn_l":"0962-8819","issn":["0962-8819","1573-9368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transgenic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030069450","display_name":"\u0415\u043b\u0435\u043d\u0430 \u0416\u0443\u043a\u043e\u0432\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elena Zhukova","raw_affiliation_strings":["CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA. ezhukova@ucla.edu","CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA. ezhukova@ucla.edu","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002020800","display_name":"Ali Sobhi Afshar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Afshar","raw_affiliation_strings":["CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112712071","display_name":"Jason Ko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Ko","raw_affiliation_strings":["CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086416002","display_name":"Paul Popper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Popper","raw_affiliation_strings":["Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226","Medical Coll of Wisconsin, Milwaukee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Wisconsin, 9200 W. Wisconsin Ave., Milwaukee, WI, 53226","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Medical Coll of Wisconsin, Milwaukee","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Pham","raw_affiliation_strings":["CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078834398","display_name":"Catia Sternini","orcid":"https://orcid.org/0000-0003-0492-1993","observed_orcids":["https://orcid.org/0000-0003-0492-1993"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catia Sternini","raw_affiliation_strings":["CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091680206","display_name":"John Henry Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Walsh","raw_affiliation_strings":["CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles, CA, 90095","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"CURE: Digestive Diseases Research Center, UCLA School of Medicine, Los Angeles,","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030069450"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.3438,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56710526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"10","issue":"4","first_page":"329","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-insulin-gene","display_name":"human insulin gene","score":0.7749999761581421},{"id":"https://openalex.org/keywords/fusion-genes","display_name":"fusion genes","score":0.8600000143051147},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.9139999747276306},{"id":"https://openalex.org/keywords/gastric-antrum","display_name":"gastric antrum","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8582642078399658},{"id":"https://openalex.org/C2776986829","wikidata":"https://www.wikidata.org/wiki/Q407181","display_name":"Gastrin","level":3,"score":0.6914674043655396},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.6454983949661255},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6224062442779541},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.5516574382781982},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5464093685150146},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.493285596370697},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.49128979444503784},{"id":"https://openalex.org/C131253125","wikidata":"https://www.wikidata.org/wiki/Q609361","display_name":"Antrum","level":3,"score":0.48724284768104553},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.47434937953948975},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4400981664657593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37623071670532227},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.2592613101005554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15324464440345764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08121240139007568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07260927557945251},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.07204541563987732}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002678","descriptor_name":"Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005755","descriptor_name":"Gastrins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011706","descriptor_name":"Pyloric Antrum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019863","descriptor_name":"Gastrin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1016641530206","doi":"https://doi.org/10.1023/a:1016641530206","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1016641530206","pdf_url":null,"source":{"id":"https://openalex.org/S190862277","display_name":"Transgenic Research","issn_l":"0962-8819","issn":["0962-8819","1573-9368"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transgenic Research","raw_type":"journal-article"},{"id":"pmid:11592712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11592712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transgenic research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4918894491","display_name":null,"funder_award_id":"DK-17294-27","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1492454134","https://openalex.org/W1503933118","https://openalex.org/W1554986753","https://openalex.org/W1555273285","https://openalex.org/W1561441276","https://openalex.org/W1569444794","https://openalex.org/W1653935866","https://openalex.org/W1887090785","https://openalex.org/W1952761671","https://openalex.org/W1966358418","https://openalex.org/W1971355445","https://openalex.org/W1972933266","https://openalex.org/W1976639033","https://openalex.org/W1977410353","https://openalex.org/W1977997274","https://openalex.org/W1987182268","https://openalex.org/W1999081985","https://openalex.org/W2013786222","https://openalex.org/W2018507159","https://openalex.org/W2026152930","https://openalex.org/W2038361342","https://openalex.org/W2043156338","https://openalex.org/W2047962309","https://openalex.org/W2060130773","https://openalex.org/W2083006866","https://openalex.org/W2086559798","https://openalex.org/W2108394804","https://openalex.org/W2134812217","https://openalex.org/W2138877348","https://openalex.org/W2141172287","https://openalex.org/W2150656078","https://openalex.org/W2211560043","https://openalex.org/W2247770826","https://openalex.org/W2273396826","https://openalex.org/W2274171927"],"related_works":["https://openalex.org/W2273396826","https://openalex.org/W2411959423","https://openalex.org/W2136814791","https://openalex.org/W2078953547","https://openalex.org/W2052378713","https://openalex.org/W7139214430","https://openalex.org/W1990571200","https://openalex.org/W2102825794","https://openalex.org/W2024993364","https://openalex.org/W2081741933"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
