{"id":"https://openalex.org/W33226227","doi":null,"title":"Bradycardia during severe but reversible hypovolemic shock in man.","display_name":"Bradycardia during severe but reversible hypovolemic shock in man.","publication_year":1984,"publication_date":"1984-01-01","ids":{"openalex":"https://openalex.org/W33226227","mag":"33226227","pmid":"https://pubmed.ncbi.nlm.nih.gov/6509730"},"language":"en","primary_location":{"id":"pmid:6509730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6509730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulatory shock","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050361725","display_name":"Niels Henry Secher","orcid":"https://orcid.org/0000-0002-5207-9932","observed_orcids":["https://orcid.org/0000-0002-5207-9932","https://orcid.org/0000-0001-7972-9731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N H Secher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044924803","display_name":"Kristin S. Jensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Sander Jensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111379474","display_name":"C. Werner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Werner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110159161","display_name":"J\u00f8rgen Warberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Warberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021943303","display_name":"Peter Bie","orcid":"https://orcid.org/0000-0002-9091-0205","observed_orcids":["https://orcid.org/0000-0002-9091-0205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Bie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.089,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.89656992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"4","first_page":"267","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.2827000021934509,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypovolemic-shock","display_name":"hypovolemic shock","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tachycardia","display_name":"tachycardia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/head-up-tilt-test","display_name":"head-up tilt","score":0.6850000023841858},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.8289999961853027},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9589999914169312},{"id":"https://openalex.org/keywords/internal-bleeding","display_name":"internal bleeding","score":0.6029999852180481},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8479999899864197},{"id":"https://openalex.org/keywords/peripheral-vasoconstriction","display_name":"peripheral vasoconstriction","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ephedrine","display_name":"ephedrine","score":0.8309999704360962},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.47600001096725464},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.5759999752044678},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.851165771484375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7269101142883301},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6904983520507812},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6872580647468567},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.6819708943367004},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5892698168754578},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.5623405575752258},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5121452808380127},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.46795833110809326},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.43638113141059875}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001919","descriptor_name":"Bradycardia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011187","descriptor_name":"Posture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012774","descriptor_name":"Shock, Traumatic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6509730","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6509730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulatory shock","raw_type":"Case Reports"},{"id":"mag:33226227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6509730","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1993195042","https://openalex.org/W2785609333","https://openalex.org/W2116087305","https://openalex.org/W2055546038","https://openalex.org/W2041086195","https://openalex.org/W2117569373","https://openalex.org/W2146298489","https://openalex.org/W2170676330","https://openalex.org/W2577787397","https://openalex.org/W2512096266","https://openalex.org/W1968642986","https://openalex.org/W2940580520","https://openalex.org/W2057688617","https://openalex.org/W2122248518","https://openalex.org/W1973467281","https://openalex.org/W2072261201","https://openalex.org/W2949374789","https://openalex.org/W2567263422","https://openalex.org/W2142142196","https://openalex.org/W2558465495","https://openalex.org/W2077832398","https://openalex.org/W2020166056","https://openalex.org/W2087313629","https://openalex.org/W2083942870","https://openalex.org/W2055010253","https://openalex.org/W2510360373","https://openalex.org/W2001354681","https://openalex.org/W2017361108","https://openalex.org/W2009780716","https://openalex.org/W2018806720","https://openalex.org/W2050871592","https://openalex.org/W2028399380","https://openalex.org/W1989770731","https://openalex.org/W1964148628","https://openalex.org/W2063269500","https://openalex.org/W2026936608","https://openalex.org/W2112063743","https://openalex.org/W2111705896"],"related_works":["https://openalex.org/W14561014","https://openalex.org/W2036466197","https://openalex.org/W2423373384","https://openalex.org/W2072654952","https://openalex.org/W2032795458","https://openalex.org/W2084075586","https://openalex.org/W147402543","https://openalex.org/W2105121568","https://openalex.org/W108942026","https://openalex.org/W2159241403"],"abstract_inverted_index":{"Severe":[0],"bleeding":[1,116],"and":[2,36,46,142,152,165,186,195,212,238],"hypovolemic":[3,223,249],"shock":[4,224],"causing":[5],"hypotension":[6],"are":[7],"most":[8,226],"often":[9,227],"associated":[10,90,134,228],"with":[11,91,114,118,135,177,229],"tachycardia.":[12],"In":[13,109],"response":[14],"to":[15,31,77,140,193,198],"passive":[16],"head-up":[17],"tilt,":[18],"five":[19],"healthy":[20],"men":[21],"exhibited":[22],"an":[23,230],"increase":[24,39,49,231,235],"in":[25,40,50,96,130,138,175,180,209,232,243],"heart":[26],"rate":[27],"(HR)":[28],"from":[29,191,196],"62":[30],"79":[32],"beats":[33,59,124,144,167,200],"X":[34,60,103,125,145,168,201],"min-1":[35,61],"a":[37,55,119,136,178,239],"gradual":[38],"the":[41,65,127,234],"plasma":[42,97],"concentration":[43],"of":[44,57,122,149,163,184],"aldosterone":[45],"protein.":[47],"The":[48,204],"HR":[51,85,121,139,162,189],"was":[52,89,133],"followed":[53],"by":[54,106],"decrease":[56,137,179],"29":[58],"(range":[62],"11-46)":[63],"at":[64],"time":[66],"when":[67],"blood":[68,80,131,153,181],"pressure":[69,81,132],"decreased":[70],"38":[71],"mmHg":[72],"(6-73).":[73],"When":[74],"tilted":[75],"back":[76],"0":[78],"degree,":[79],"immediately":[82],"reversed":[83],"while":[84],"remained":[86],"unchanged.":[87],"Hypotension":[88],"large":[92],"but":[93,245],"variable":[94],"increases":[95],"vasopressin":[98],"(86":[99],"+/-":[100],"28":[101],"pg":[102],"ml-1)":[104],"accompanied":[105],"peripheral":[107],"vasoconstriction.":[108],"two":[110,206],"cases":[111],"where":[112],"patients":[113,159,207],"internal":[115,216],"presented":[117],"moderate":[120],"96":[123],"min-1,":[126,146,169,202],"ensuing":[128],"fall":[129],"68":[141],"76":[143],"respectively.":[147,203],"Administration":[148,183],"albumin":[150],"solution":[151],"normalized":[154],"cardiovascular":[155],"function.":[156],"Two":[157],"other":[158],"showing":[160],"initial":[161],"130":[164],"100":[166],"respectively,":[170],"also":[171],"developed":[172],"relative":[173],"bradycardia":[174,211,241],"conjunction":[176],"pressure.":[182],"ephedrine":[185],"atropine":[187],"increased":[188],"temporarily":[190],"56":[192],"90":[194],"36":[197],"110":[199],"latter":[205],"died":[208],"extreme":[210],"autopsies":[213],"revealed":[214],"severe":[215,244],"bleeding.":[217],"It":[218],"is":[219,225,236],"concluded":[220],"that":[221],"although":[222],"HR,":[233],"modest":[237],"paradoxical":[240],"develops":[242],"potentially":[246],"reversible":[247],"hypotensive":[248],"shock.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}