{"id":"https://openalex.org/W33188814","doi":null,"title":"Effects of enzyme-potentiated desensitization in the treatment of pollinosis: a double-blind placebo-controlled trial.","display_name":"Effects of enzyme-potentiated desensitization in the treatment of pollinosis: a double-blind placebo-controlled trial.","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W33188814","mag":"33188814","pmid":"https://pubmed.ncbi.nlm.nih.gov/8844502"},"language":"en","primary_location":{"id":"pmid:8844502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8844502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026270505","display_name":"Corrado Astarita","orcid":"https://orcid.org/0000-0002-6972-466X","observed_orcids":["https://orcid.org/0000-0002-6972-466X"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Astarita","raw_affiliation_strings":["Dipartimento di Internistica Clinica e Sperimentale, II Universit\u00e0 di Napoli, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Internistica Clinica e Sperimentale, II Universit\u00e0 di Napoli, Italy","institution_ids":["https://openalex.org/I197809005","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G Scala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Scala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054527569","display_name":"S Sproviero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sproviero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033809955","display_name":"A Franzese","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Franzese","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2886,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"4","first_page":"248","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pollinosis","display_name":"pollinosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/beta-glucuronidase","display_name":"beta-glucuronidase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/grass-pollen-allergy","display_name":"grass pollen allergy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ige","display_name":"IgE","score":0.5149999856948853},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/immune-deviation","display_name":"immune deviation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/symptom-scores","display_name":"symptom scores","score":0.5210000276565552},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9499204158782959},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6492739915847778},{"id":"https://openalex.org/C2779699568","wikidata":"https://www.wikidata.org/wiki/Q1115038","display_name":"rhinorrhea","level":2,"score":0.6420974731445312},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.5824395418167114},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5130121111869812},{"id":"https://openalex.org/C2779923671","wikidata":"https://www.wikidata.org/wiki/Q199602","display_name":"Itching","level":2,"score":0.4991297721862793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44904956221580505},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.4134179651737213},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36384090781211853},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.350869357585907},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2923513650894165},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27459126710891724},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09475201368331909},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005966","descriptor_name":"Glucuronidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006109","descriptor_name":"Poaceae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011058","descriptor_name":"Pollen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8844502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8844502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of investigational allergology & clinical immunology","raw_type":"Clinical Trial"},{"id":"mag:33188814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8844502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W217408579","https://openalex.org/W1499991744","https://openalex.org/W1561954725","https://openalex.org/W1632602478","https://openalex.org/W1968892236","https://openalex.org/W1972048297","https://openalex.org/W1995737779","https://openalex.org/W2002021284","https://openalex.org/W2005979071","https://openalex.org/W2013899055","https://openalex.org/W2023928925","https://openalex.org/W2037049436","https://openalex.org/W2039376644","https://openalex.org/W2042678671","https://openalex.org/W2050313335","https://openalex.org/W2055966372","https://openalex.org/W2057998085","https://openalex.org/W2076367714","https://openalex.org/W2088439563","https://openalex.org/W2091082139","https://openalex.org/W2093560365","https://openalex.org/W2107277218","https://openalex.org/W2118122261","https://openalex.org/W2121931853","https://openalex.org/W2126853906","https://openalex.org/W2128439137","https://openalex.org/W2134622113","https://openalex.org/W2138942193","https://openalex.org/W2141539294","https://openalex.org/W2144690533","https://openalex.org/W2153732050","https://openalex.org/W2159684138","https://openalex.org/W2161091901","https://openalex.org/W2167702845","https://openalex.org/W2168650324","https://openalex.org/W2235575748","https://openalex.org/W2257603240","https://openalex.org/W2343326175","https://openalex.org/W2587889946","https://openalex.org/W2595751532","https://openalex.org/W2607178217","https://openalex.org/W2618077962","https://openalex.org/W2622879952","https://openalex.org/W2768736543","https://openalex.org/W2799524357","https://openalex.org/W2810249326","https://openalex.org/W2892968638","https://openalex.org/W2893455966","https://openalex.org/W2894252291","https://openalex.org/W2913154879","https://openalex.org/W2938037005","https://openalex.org/W2952864101","https://openalex.org/W2967866078"],"related_works":["https://openalex.org/W2051032332","https://openalex.org/W2423872505","https://openalex.org/W2387740586","https://openalex.org/W2236145131","https://openalex.org/W2080653630","https://openalex.org/W2092203805","https://openalex.org/W150396591","https://openalex.org/W2077247933","https://openalex.org/W2185483396","https://openalex.org/W2424558908"],"abstract_inverted_index":{"Several":[0],"controlled":[1],"clinical":[2,78,171,187,298],"trials":[3],"have":[4,32,66],"shown":[5],"that":[6],"specific":[7,144,258,290],"immunotherapy":[8,48],"(SIT)":[9],"using":[10,199],"incremental":[11],"injections":[12],"of":[13,21,29,38,53,71,80,85,91,118,195,202,219,242,256,275,288,300,303,310,357,371],"allergens":[14,55,304],"can":[15],"be":[16],"effective":[17,353],"in":[18,82,124,184,189,208,238,252,271,284,313,334,354,363],"the":[19,27,77,83,162,175,179,193,209,239,253,261,272,285,301,311,314,335,355,364],"treatment":[20,84,356],"allergic":[22,170],"rhinitis":[23],"and":[24,99,131,137,143,148,151,226,247,279,325],"asthma.":[25],"Nevertheless,":[26],"risk":[28],"side":[30,64],"effects":[31,65,194],"led":[33],"to":[34,75,97,174,178,191,308],"some":[35],"recommended":[36],"limitations":[37],"SIT.":[39],"Enzyme-potentiated":[40],"desensitization":[41],"(EPD)":[42],"is":[43,351],"a":[44,114,200,216,234,248,266,280,339],"proposed":[45],"method":[46],"for":[47,59,110,221,227],"with":[49,168,215,292],"very":[50],"low":[51],"doses":[52],"mixed":[54],"plus":[56],"beta-glucuronidase":[57],"enzyme,":[58],"which":[60],"irrelevant":[61],"or":[62,120],"no":[63,293],"been":[67],"claimed.":[68],"The":[69],"aim":[70],"this":[72],"study":[73],"was":[74,102],"determine":[76],"efficacy":[79],"EPD":[81,92,119,196,317,350],"pollinosis.":[86,358],"A":[87],"double-blind":[88,180,315],"placebo-controlled":[89],"trial":[90,188],"among":[93],"20":[94],"patients":[95,105,232,264,332,366],"sensitive":[96],"Parietaria":[98,257,289],"grass":[100],"pollen":[101],"performed.":[103],"All":[104],"recorded":[106,127],"daily":[107],"symptom":[108,224],"scores":[109,205],"nine":[111],"months":[112],"following":[113],"single":[115],"intradermal":[116],"injection":[117,305,318],"buffered":[121],"saline":[122],"received":[123],"February.":[125],"Symptoms":[126],"were":[128,146,156,182,206,306],"nasal":[129],"itching":[130],"obstruction,":[132],"sneezing,":[133],"rhinorrhea,":[134],"itchy":[135],"eyes":[136],"excessive":[138],"tear":[139],"production.":[140],"Moreover,":[141],"total":[142],"lgE":[145,291],"measured":[147],"CD3+,":[149],"CD4+":[150],"CD8+":[152,276],"peripheral":[153,244],"blood":[154,245],"lymphocytes":[155],"counted":[157],"at":[158],"different":[159],"times.":[160],"In":[161,348],"same":[163],"period,":[164],"ten":[165],"additional":[166],"subjects,":[167],"an":[169,185,321,368],"profile":[172],"similar":[173,217,307],"subjects":[176],"admitted":[177],"trial,":[181],"studied":[183],"open":[186],"order":[190],"evaluate":[192],"without":[197],"enzyme":[198],"mixture":[201,302],"allergens.":[203],"Symptom":[204],"higher":[207],"placebo":[210,312],"group":[211,337],"(p":[212],"<":[213],"0.001),":[214],"level":[218],"significance":[220],"both":[222],"global":[223],"score":[225],"each":[228],"individual":[229],"symptom.":[230],"Active-treated":[231],"had":[233,265],"significant":[235,249,268,281,294],"post-treatment":[236],"increase":[237,283],"mean":[240,254,273,286],"percentage":[241,255,274,287],"T-CD8+":[243],"cells":[246,278],"post-seasonal":[250,269,295],"decrease":[251,270],"lgE.":[259],"On":[260],"contrary,":[262],"placebo-treated":[263],"borderline":[267],"circulating":[277],"seasonal":[282],"decrease.":[296],"Finally,":[297],"results":[299],"those":[309],"trial.":[316],"caused":[319],"only":[320],"asymptomatic,":[322],"local":[323],"wheal":[324],"flare":[326],"lasting":[327,344],"about":[328,345],"two":[329,346],"hours.":[330],"Two":[331],"(20%)":[333],"active-treated":[336],"experienced":[338],"delayed,":[340],"mild,":[341],"unusual":[342],"headache":[343],"days.":[347],"conclusion,":[349],"clinically":[352],"Some":[359],"immunological":[360],"modifications":[361],"observed":[362],"EPD-treated":[365],"suggest":[367],"EPD-induced":[369],"enhancement":[370],"tolerogenic":[372],"mechanisms":[373],"like":[374],"\"immune":[375],"deviation.\"":[376]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}