{"id":"https://openalex.org/W331399997","doi":"https://doi.org/10.1164/arrd.1986.134.2.233","title":"Effects of common therapeutic concentrations of oxygen on lung clearance of 99mTc DTPA and bronchoalveolar lavage albumin concentration.","display_name":"Effects of common therapeutic concentrations of oxygen on lung clearance of 99mTc DTPA and bronchoalveolar lavage albumin concentration.","publication_year":1986,"publication_date":"1986-08-01","ids":{"openalex":"https://openalex.org/W331399997","doi":"https://doi.org/10.1164/arrd.1986.134.2.233","mag":"331399997","pmid":"https://pubmed.ncbi.nlm.nih.gov/3527005"},"language":"en","primary_location":{"id":"pmid:3527005","doi":"https://doi.org/10.1164/arrd.1986.134.2.233","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3527005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074399838","display_name":"David E. Griffith","orcid":"https://orcid.org/0000-0003-1458-3385","observed_orcids":["https://orcid.org/0000-0003-1458-3385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Griffith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027788471","display_name":"William E. Holden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W E Holden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"J F Morris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Morris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017555366","display_name":"Leo K. Min","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L K Min","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111561641","display_name":"Gerbail T. Krishnamurthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G T Krishnamurthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6884,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88173217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"134","issue":"2","first_page":"233","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.2667999863624573,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0494999997317791,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.6129999756813049},{"id":"https://openalex.org/keywords/99mtc-dtpa","display_name":"99mTc-DTPA","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lung-clearance","display_name":"lung clearance","score":0.734000027179718},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.9079999923706055},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.6520000100135803},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.3880000114440918},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.47600001096725464},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.843999981880188},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8809999823570251},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9020000100135803},{"id":"https://openalex.org/keywords/extracellular-potassium","display_name":"extracellular potassium","score":0.6990000009536743},{"id":"https://openalex.org/keywords/humidified-oxygen","display_name":"humidified oxygen","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.8647276759147644},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.7430993318557739},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.7059724926948547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5065449476242065},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4527592062950134},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.43954741954803467},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.41020703315734863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38633379340171814},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3660462498664856},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35398828983306885},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2676946818828583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13595429062843323},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.073905348777771},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004369","descriptor_name":"Pentetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006813","descriptor_name":"Humidity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007507","descriptor_name":"Therapeutic Irrigation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013667","descriptor_name":"Technetium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016284","descriptor_name":"Technetium Tc 99m Pentetate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3527005","doi":"https://doi.org/10.1164/arrd.1986.134.2.233","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3527005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American review of respiratory disease","raw_type":"Journal Article"},{"id":"mag:331399997","doi":"https://doi.org/10.1164/arrd.1986.134.2.233","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3527005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2403415429","https://openalex.org/W2016768671","https://openalex.org/W2412588724","https://openalex.org/W2000703640","https://openalex.org/W4387437376","https://openalex.org/W1989993923","https://openalex.org/W2128859862","https://openalex.org/W87109714","https://openalex.org/W2071034702","https://openalex.org/W1575639250"],"abstract_inverted_index":{"We":[0,36,161],"studied":[1],"the":[2,24,47,157,171,181,184],"effects":[3],"of":[4,15,26,33,41,76,86,91,115,151,165,197,212],"oxygen":[5,67,87,111,143,159,186,189],"concentrations":[6,191],"(21":[7],"to":[8,109,179],"50%)":[9],"considered":[10,192],"clinically":[11,193],"\"safe\"":[12,194],"on":[13],"clearance":[14,196],"inhaled":[16,66,124],"technetium-labeled":[17],"diethylene":[18],"triamine":[19],"pentaacetate":[20],"(99mTc":[21],"DTPA)":[22],"and":[23,44,52,62,112,138,200],"concentration":[25,90,203],"albumin":[27,92,202],"in":[28,46,93,102,106,121,132,156,170,183,190,204],"bronchoalveolar":[29],"lavage":[30],"(BAL)":[31],"fluid":[32,49,95,134],"normal":[34,205],"subjects.":[35],"also":[37],"measured":[38],"several":[39,63],"markers":[40],"cell":[42,54,140,166],"injury":[43,167],"inflammation":[45,169],"BAL":[48,94,133,172,201],"including":[50],"total":[51,137],"differential":[53,139],"counts,":[55],"lactate":[56],"dehydrogenase,":[57],"alkaline":[58],"phosphatase,":[59],"extracellular":[60],"potassium,":[61],"eicosanoids.":[64],"Subjects":[65],"(50,":[68],"40,":[69],"30,":[70],"or":[71,83,136,168],"21%)":[72],"for":[73],"a":[74,103,208],"mean":[75],"45":[77],"h;":[78],"there":[79],"were":[80,128],"no":[81,129,163],"symptoms":[82],"bronchoscopic":[84],"signs":[85],"toxicity.":[88],"The":[89],"was":[96,118,154],"increased":[97,119,149],"compared":[98],"with":[99],"baseline":[100],"measurements":[101],"dose-dependent":[104],"manner":[105],"subjects":[107,122,206],"exposed":[108],"30%":[110],"above.":[113],"Clearance":[114],"99mTc":[116,198],"DTPA":[117,199],"only":[120],"who":[123],"50%":[125,158,185],"oxygen.":[126],"There":[127],"significant":[130],"changes":[131],"volume":[135],"counts":[141],"after":[142,207],"exposure.":[144,213],"A":[145],"trend":[146],"towards":[147],"an":[148],"percentage":[150],"polymorphonuclear":[152],"leukocytes":[153],"noted":[155],"group.":[160,187],"found":[162],"evidence":[164],"fluid.":[173],"Supplemental":[174],"humidity":[175],"did":[176],"not":[177],"appear":[178],"influence":[180],"findings":[182],"Thus,":[188],"increases":[195],"relatively":[209],"short":[210],"time":[211]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}