{"id":"https://openalex.org/W330968426","doi":null,"title":"Abstract 14588: MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells","display_name":"Abstract 14588: MicroRNA-34a Regulated Sirtuin 1 is Required for Smooth Muscle Cell Differentiation From Murine and Human Embryonic Stem Cells","publication_year":2013,"publication_date":"2013-11-26","ids":{"openalex":"https://openalex.org/W330968426","mag":"330968426"},"language":"en","primary_location":{"id":"mag:330968426","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.128.suppl_22.a14588","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063005747","display_name":"Xiaotian Yu","orcid":"https://orcid.org/0000-0001-8428-4650","observed_orcids":["https://orcid.org/0000-0001-8428-4650","https://orcid.org/0000-0002-7761-2377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaotian Yu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7761-2377","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100425554","display_name":"Li Zhang","orcid":"https://orcid.org/0000-0002-3617-2627","observed_orcids":["https://orcid.org/0000-0002-3617-2627","https://orcid.org/0000-0003-2756-2620","https://orcid.org/0009-0001-8129-4308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3617-2627","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101139639","display_name":"Guanmei Wen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanmei Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103179058","display_name":"Hanqing Zhao","orcid":"https://orcid.org/0000-0002-6661-2056","observed_orcids":["https://orcid.org/0000-0002-6661-2056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanqing Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6661-2056","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518517","display_name":"Yuan Huang","orcid":"https://orcid.org/0000-0001-8126-2798","observed_orcids":["https://orcid.org/0000-0001-8126-2798","https://orcid.org/0009-0000-3697-186X","https://orcid.org/0009-0001-8390-9310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Huang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8126-2798","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044300240","display_name":"Jianhua Zhu","orcid":"https://orcid.org/0000-0001-7746-4100","observed_orcids":["https://orcid.org/0000-0001-7746-4100","https://orcid.org/0000-0002-9706-1437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianhua Zhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7746-4100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022101190","display_name":"Qingbo Xu","orcid":"https://orcid.org/0000-0003-2474-8155","observed_orcids":["https://orcid.org/0000-0003-2474-8155","https://orcid.org/0000-0002-6414-2273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingbo Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6414-2273","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043307364","display_name":"Shu Ye","orcid":"https://orcid.org/0000-0002-4126-4278","observed_orcids":["https://orcid.org/0000-0002-4126-4278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu Ye","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4126-4278","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100396391","display_name":"Wen Wang","orcid":"https://orcid.org/0000-0003-3215-3020","observed_orcids":["https://orcid.org/0000-0003-3215-3020","https://orcid.org/0009-0004-7837-507X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3215-3020","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068399979","display_name":"Qingzhong Xiao","orcid":"https://orcid.org/0000-0001-9101-0498","observed_orcids":["https://orcid.org/0000-0001-9101-0498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingzhong Xiao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9101-0498","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"128","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.032600000500679016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.027400000020861626,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-34a","display_name":"miR-34a","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/smooth-muscle-cell-differentiation","display_name":"smooth muscle differentiation","score":0.949999988079071},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/srf","display_name":"SRF","score":0.6359999775886536},{"id":"https://openalex.org/keywords/myocardin","display_name":"myocardin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mef2c","display_name":"MEF2C","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2780286377","wikidata":"https://www.wikidata.org/wiki/Q18048730","display_name":"Myocardin","level":5,"score":0.7607463002204895},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7537584900856018},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7505776882171631},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6629688739776611},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6270022392272949},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5948620438575745},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5669890642166138},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5574851036071777},{"id":"https://openalex.org/C146291010","wikidata":"https://www.wikidata.org/wiki/Q18029008","display_name":"MEF2C","level":4,"score":0.4985666275024414},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.47709542512893677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4331645369529724},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36759525537490845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3480478823184967},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30391356348991394},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2998528480529785},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.22023040056228638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20343682169914246},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.1939111053943634},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11196738481521606}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:330968426","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.128.suppl_22.a14588","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2059493282","https://openalex.org/W2271637213","https://openalex.org/W2290328508","https://openalex.org/W2888062991","https://openalex.org/W2060737779","https://openalex.org/W1990905462","https://openalex.org/W4366334544","https://openalex.org/W2193255881","https://openalex.org/W2619684706","https://openalex.org/W1996630410"],"abstract_inverted_index":{"Background:":[0],"microRNA-34a":[1],"(miR-34a)":[2],"has":[3],"been":[4],"recently":[5],"reported":[6],"to":[7,77,80],"regulate":[8],"tumor":[9],"cell":[10,29],"cycle":[11],"progression":[12],"and":[13,45,57,70,94,104,112,117,126,132],"apoptosis.":[14],"However,":[15],"very":[16],"little":[17],"is":[18],"known":[19],"about":[20],"the":[21,36,41],"functional":[22],"role":[23,52],"of":[24,96,114],"miR-34a":[25,85,115,133],"in":[26,53,72,98,128,135],"smooth":[27],"muscle":[28],"(SMC)":[30],"differentiation":[31,73],"from":[32],"stem":[33,61,136],"cells.":[34],"In":[35],"present":[37],"study,":[38],"we":[39],"assessed":[40],"hypothesis":[42],"that":[43],"miR34a":[44,97],"its":[46],"target":[47],"genes":[48],"play":[49],"an":[50],"important":[51],"SMC":[54,83,90,120,139],"differentiation.":[55,84,91],"Methods":[56],"results:":[58],"Mouse":[59],"embryonic":[60],"(ES)":[62],"cells":[63,101,137],"were":[64],"seeded":[65],"on":[66],"collagen":[67],"IV-coated":[68],"flasks":[69],"cultured":[71],"medium":[74],"for":[75,82],"4":[76],"8":[78],"days":[79],"allow":[81],"was":[86],"significantly":[87,102],"upregulated":[88,116],"during":[89],"Enforced":[92],"expression":[93],"knockdown":[95,113],"differentiating":[99],"ES":[100],"promoted":[103,138],"inhibited":[105],"SMC-specific":[106],"gene":[107],"expressions,":[108],"respectively.":[109],"Furthermore,":[110],"overexpression":[111,134],"downregulated":[118],"several":[119],"transcription":[121],"factors,":[122],"including":[123],"SRF,":[124],"myocardin":[125],"MEF2c":[127],"a":[129],"similar":[130],"manner,":[131],"differentiatio...":[140]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
