{"id":"https://openalex.org/W33092665","doi":null,"title":"Establishing Vertebrate Model Systems for the Study of Gle1 Mediated Motor Neuron Disease","display_name":"Establishing Vertebrate Model Systems for the Study of Gle1 Mediated Motor Neuron Disease","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W33092665","mag":"33092665"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt6v8887xt","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6v8887xt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085674785","display_name":"Joseph Tsai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Tsai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085674785"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.04639999940991402,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gle1","display_name":"Gle1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/motor-neuron-disease","display_name":"motor neuron disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mrna-export","display_name":"mRNA export","score":0.7549999952316284},{"id":"https://openalex.org/keywords/mrna-regulation","display_name":"mRNA regulation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/motor-neuron-development","display_name":"motor neuron development","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.4869999885559082},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7990000247955322},{"id":"https://openalex.org/keywords/truncated-protein","display_name":"truncated protein","score":0.6430000066757202},{"id":"https://openalex.org/keywords/gain-of-function","display_name":"gain-of-function","score":0.6269999742507935},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7620421051979065},{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.7542091608047485},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.528390109539032},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4594391882419586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4558609127998352},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3621339201927185},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3392200469970703},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt6v8887xt","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6v8887xt","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:33092665","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt6v8887xt/qt6v8887xt.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8868475092","display_name":"Eating, Activity, and Weight-Related Problems Across the Life Course in Diverse Populations","funder_award_id":"R35HL139853","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1556426653","https://openalex.org/W1964996586","https://openalex.org/W1965850074","https://openalex.org/W1966677529","https://openalex.org/W1970827552","https://openalex.org/W1974365957","https://openalex.org/W1983315505","https://openalex.org/W1984684782","https://openalex.org/W1993064034","https://openalex.org/W1998535063","https://openalex.org/W2002364516","https://openalex.org/W2007165715","https://openalex.org/W2009482935","https://openalex.org/W2010364898","https://openalex.org/W2016332933","https://openalex.org/W2028051736","https://openalex.org/W2028093783","https://openalex.org/W2028183921","https://openalex.org/W2042973755","https://openalex.org/W2044307053","https://openalex.org/W2046452940","https://openalex.org/W2052238208","https://openalex.org/W2056116259","https://openalex.org/W2068410472","https://openalex.org/W2069717852","https://openalex.org/W2070686658","https://openalex.org/W2074052524","https://openalex.org/W2074581529","https://openalex.org/W2075556356","https://openalex.org/W2076047037","https://openalex.org/W2085465310","https://openalex.org/W2087202439","https://openalex.org/W2087331958","https://openalex.org/W2087339505","https://openalex.org/W2089689396","https://openalex.org/W2100111801","https://openalex.org/W2102115478","https://openalex.org/W2107660300","https://openalex.org/W2114921531","https://openalex.org/W2134505400","https://openalex.org/W2135107819","https://openalex.org/W2136401958","https://openalex.org/W2140912731","https://openalex.org/W2142396207","https://openalex.org/W2143414328","https://openalex.org/W2148071380","https://openalex.org/W2151093888","https://openalex.org/W2154745705","https://openalex.org/W2155632240","https://openalex.org/W2159248478","https://openalex.org/W2163503448"],"related_works":["https://openalex.org/W6997432364","https://openalex.org/W2277159485","https://openalex.org/W2167536144","https://openalex.org/W2140912731","https://openalex.org/W6983628692","https://openalex.org/W1529108240","https://openalex.org/W1963493016","https://openalex.org/W6983778484","https://openalex.org/W1963594713","https://openalex.org/W4412492215"],"abstract_inverted_index":{"Gle1":[0,19,68,100,125,137,144,177,192,220,237],"is":[1,37,58,193],"an":[2],"evolutionary":[3],"conserved":[4],"protein":[5,162,198],"involved":[6],"in":[7,18,40,53,60,69,102,156,190,215,225],"both":[8],"mRNA":[9,61],"export":[10],"and":[11,22,76,89,108,117,127,140,243],"translation.":[12],"A":[13],"recent":[14],"study":[15,124,173],"linked":[16,199],"mutations":[17],"with":[20],"recessive":[21],"fatal":[23],"motor":[24,31,55,70,114,154,240],"neuron":[25,32,56,71,115,241],"diseases":[26],"characterized":[27],"by":[28],"ventral":[29],"horn":[30],"degeneration":[33],"before":[34],"birth.":[35],"This":[36],"particularly":[38],"interesting":[39],"light":[41],"of":[42,46,67,99,105,110,131,153,170,176,236],"a":[43,50,103,168,183,187,196,212,226],"growing":[44],"pool":[45],"evidence":[47],"indicating":[48],"that":[49,159],"common":[51],"denominator":[52],"many":[54],"disorders":[57],"defects":[59],"regulation.":[62],"To":[63,172],"investigate":[64],"the":[65,97,151,160,174,222,233],"role":[66],"development,":[72,111,116,180],"we":[73,118,181,210,217],"used":[74],"chick":[75],"mouse":[77,184],"models":[78],"to":[79,123,134,148,200,231],"develop":[80],"tools":[81],"for":[82,205],"examining":[83],"Gle1s\u0300":[84],"expression,":[85],"localization,":[86],"biochemical":[87],"interactions,":[88],"altered":[90],"activity":[91],"when":[92],"mutated.":[93],"We":[94],"have":[95],"confirmed":[96],"presence":[98],"transcripts":[101],"variety":[104],"cell":[106],"types":[107],"stages":[109],"including":[112],"during":[113],"generated":[119,182],"Gle1-Flag":[120],"fusion":[121],"constructs":[122],"localization":[126],"biochemistry":[128],"following":[129],"failure":[130],"commercial":[132],"antibodies":[133],"reliably":[135],"detect":[136],"through":[138,167],"immunohistochemistry":[139],"immunoblotting.":[141],"Overexpressing":[142],"mutant":[143,161],"does":[145,163],"not":[146,164],"appear":[147,208],"noticeably":[149],"affect":[150],"development":[152],"neurons":[155],"chick,":[157],"suggesting":[158],"cause":[165],"disease":[166],"gain":[169],"function.":[171],"effects":[175,235],"loss":[178],"on":[179,239],"line":[185],"expressing":[186],"Gene-trap":[188,227],"allele":[189,207],"which":[191,216],"created":[194],"as":[195],"truncated":[197],"[Beta]-Geo.":[201],"As":[202],"animals":[203],"homozygous":[204],"this":[206],"nonviable,":[209],"selected":[211],"rescue":[213],"strategy":[214],"will":[218],"express":[219],"from":[221],"ROSA26":[223],"locus":[224],"background,":[228],"allowing":[229],"us":[230],"examine":[232],"specific":[234],"mutation":[238],"survival":[242],"function":[244]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}