{"id":"https://openalex.org/W330879960","doi":null,"title":"The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes.","display_name":"The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes.","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W330879960","mag":"330879960","pmid":"https://pubmed.ncbi.nlm.nih.gov/16212921"},"language":"en","primary_location":{"id":"pmid:16212921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16212921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular & molecular immunology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058549598","display_name":"Heng Yi Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heng Yi Tao","raw_affiliation_strings":["Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031292318","display_name":"Chun Fu Wu","orcid":"https://orcid.org/0000-0002-0176-3873","observed_orcids":["https://orcid.org/0000-0002-0176-3873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun Fu Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101571039","display_name":"Ye Zhou","orcid":"https://orcid.org/0000-0002-9751-6577","observed_orcids":["https://orcid.org/0000-0002-9751-6577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ye Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wang Hua Gong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang Hua Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101660587","display_name":"Xia Zhang","orcid":"https://orcid.org/0000-0003-1425-6026","observed_orcids":["https://orcid.org/0000-0003-1425-6026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001718933","display_name":"Pablo Iribarren","orcid":"https://orcid.org/0000-0002-5679-4386","observed_orcids":["https://orcid.org/0000-0002-5679-4386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pablo Iribarren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080836885","display_name":"Yu Zhao","orcid":"https://orcid.org/0000-0003-2891-5221","observed_orcids":["https://orcid.org/0000-0003-2891-5221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Qing Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104015651","display_name":"Ying Ying Le","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Ying Le","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103178695","display_name":"Ji Ming Wang","orcid":"https://orcid.org/0000-0002-7381-5695","observed_orcids":["https://orcid.org/0000-0002-7381-5695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji Ming Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4577,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.68201949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"1","first_page":"50","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":1.0},{"id":"https://openalex.org/keywords/chemoattractant-receptors","display_name":"chemoattractant receptors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/formyl-peptide-receptor","display_name":"formyl peptide receptor","score":0.9010000228881836},{"id":"https://openalex.org/keywords/phagocytic-leukocytes","display_name":"phagocytic leukocytes","score":0.8730000257492065},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/superoxide-production","display_name":"superoxide production","score":0.9779999852180481},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.5619999766349792},{"id":"https://openalex.org/keywords/fmlp","display_name":"fMLP","score":0.7170000076293945},{"id":"https://openalex.org/keywords/grape-polyphenols","display_name":"grape polyphenols","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.913459837436676},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7583339214324951},{"id":"https://openalex.org/C2776731609","wikidata":"https://www.wikidata.org/wiki/Q24782993","display_name":"Formyl peptide receptor","level":4,"score":0.6272842884063721},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5959716439247131},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5757510662078857},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5639680624008179},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5264716148376465},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5093454122543335},{"id":"https://openalex.org/C2780656570","wikidata":"https://www.wikidata.org/wiki/Q5090627","display_name":"N-Formylmethionine leucyl-phenylalanine","level":4,"score":0.4797286093235016},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4680715799331665},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4492640495300293},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.445169597864151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43916499614715576},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4378880560398102},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.43184694647789},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4179390072822571},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3874700963497162},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31249600648880005},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15788453817367554}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002630","descriptor_name":"Chemotactic Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010586","descriptor_name":"Phagocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027843","descriptor_name":"Vitis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044042","descriptor_name":"Receptors, Formyl Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16212921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16212921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular & molecular immunology","raw_type":"Journal Article"},{"id":"mag:330879960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16212921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G174812244","display_name":"DCTD Computer Support","funder_award_id":"n01co12400-79-0-22","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1541841154","https://openalex.org/W1571048371","https://openalex.org/W1577244262","https://openalex.org/W1667300941","https://openalex.org/W1767991896","https://openalex.org/W1881147845","https://openalex.org/W1938006201","https://openalex.org/W1979501382","https://openalex.org/W1979751791","https://openalex.org/W1979953806","https://openalex.org/W1984485329","https://openalex.org/W1987181986","https://openalex.org/W2029090440","https://openalex.org/W2056918752","https://openalex.org/W2060760516","https://openalex.org/W2066068025","https://openalex.org/W2079168625","https://openalex.org/W2089750544","https://openalex.org/W2090703365","https://openalex.org/W2096699393","https://openalex.org/W2129588307","https://openalex.org/W2132342511","https://openalex.org/W2132552167","https://openalex.org/W2136220974","https://openalex.org/W2140332898","https://openalex.org/W2140575920","https://openalex.org/W2140690574","https://openalex.org/W2147106724","https://openalex.org/W2151600299","https://openalex.org/W2165257835","https://openalex.org/W2169759699","https://openalex.org/W2249998205","https://openalex.org/W2254553501","https://openalex.org/W2275966466","https://openalex.org/W2324091890","https://openalex.org/W2460400966"],"related_works":["https://openalex.org/W7095677874","https://openalex.org/W2071623422","https://openalex.org/W2008737991","https://openalex.org/W4321500120","https://openalex.org/W3158941633","https://openalex.org/W183162841","https://openalex.org/W2050665806","https://openalex.org/W7033792629","https://openalex.org/W6983490863","https://openalex.org/W2460400966"],"abstract_inverted_index":{"Resveratrol":[0],"(3,5,4'-trihydroxystilbene)":[1],"(RV)":[2],"is":[3],"a":[4,43,80,96],"constituent":[5],"of":[6,21,27,53,108,116,131,134,143,156],"grape":[7],"seeds":[8],"with":[9],"anti-inflammatory":[10,141],"and":[11,38,49,88,95,113],"anti-oxidant":[12],"activities.":[13],"In":[14,103],"this":[15],"study,":[16],"we":[17],"examined":[18],"the":[19,25,75,99,114,129,132,140,161],"capacity":[20],"RV":[22,63,105,146],"to":[23,56,74,139,160],"modulate":[24],"function":[26,133],"G":[28],"protein-coupled":[29],"chemoattractant":[30,135],"receptors,":[31],"which":[32,154],"play":[33],"important":[34],"roles":[35],"in":[36,72,153],"inflammation":[37],"immune":[39],"responses.":[40],"RV,":[41],"over":[42],"non-cytotoxic":[44],"concentration":[45],"range,":[46],"inhibited":[47],"chemotactic":[48,77],"calcium":[50],"mobilization":[51],"responses":[52],"phagocytic":[54,70],"cells":[55],"selected":[57],"chemoattractants.":[58],"At":[59],"low":[60],"micromolar":[61],"concentrations,":[62],"potently":[64],"reduced":[65,106],"superoxide":[66],"anion":[67],"production":[68],"by":[69,121],"leukocytes":[71],"response":[73],"bacterial":[76],"peptide":[78,94],"fMLF,":[79],"high":[81],"affinity":[82],"ligand":[83,97],"for":[84,98,151],"formylpeptide":[85,122,157],"receptor":[86,123],"FPR,":[87],"A":[89],"beta42,":[90],"an":[91],"Alzheimer's":[92],"disease-associated":[93],"FPR":[100],"variant":[101],"FPRL1.":[102],"addition,":[104],"phosphorylation":[107],"extracellular":[109],"signal-regulated":[110],"kinase":[111],"(ERK1/2)":[112],"activation":[115,155],"nuclear":[117],"factor":[118],"NF-kappaB":[119],"induced":[120],"agonists.":[124],"These":[125],"results":[126],"suggest":[127],"that":[128],"inhibition":[130],"receptors":[136,158],"may":[137,147],"contribute":[138],"properties":[142],"RV.":[144],"Thus,":[145],"be":[148],"therapeutically":[149],"promising":[150],"diseases":[152],"contributes":[159],"pathogenic":[162],"processes.":[163]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}