{"id":"https://openalex.org/W33085757","doi":null,"title":"Isolated total lung perfusion as a means to deliver organ-specific chemotherapy: long-term studies in animals.","display_name":"Isolated total lung perfusion as a means to deliver organ-specific chemotherapy: long-term studies in animals.","publication_year":1985,"publication_date":"1985-07-01","ids":{"openalex":"https://openalex.org/W33085757","mag":"33085757","pmid":"https://pubmed.ncbi.nlm.nih.gov/4012605"},"language":"en","primary_location":{"id":"pmid:4012605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4012605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038663739","display_name":"Johnston Mr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M R Johnston","raw_affiliation_strings":["Marquette University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marquette University","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077145774","display_name":"Christensen Cw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C W Christensen","raw_affiliation_strings":["Marquette University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marquette University","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055028859","display_name":"Rodney F. Minchin","orcid":"https://orcid.org/0000-0002-3178-4835","observed_orcids":["https://orcid.org/0000-0002-3178-4835"]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R F Minchin","raw_affiliation_strings":["Marquette University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marquette University","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024546839","display_name":"Rickaby Da","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Rickaby","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109935848","display_name":"John H. Linehan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Linehan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026955509","display_name":"Sch\u00fcller Hm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H M Schuller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058355499","display_name":"Boyd Mr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Boyd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025659978","display_name":"C A Dawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Dawson","raw_affiliation_strings":["Medical Coll of Wisconsin, Milwaukee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Coll of Wisconsin, Milwaukee","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6887,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.68938952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"98","issue":"1","first_page":"35","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.2786000072956085,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0949999988079071,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isolated-lung-perfusion","display_name":"isolated lung perfusion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pulmonary-artery-cannulation","display_name":"pulmonary artery cannulation","score":0.6079999804496765},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.9139999747276306},{"id":"https://openalex.org/keywords/cross-contamination","display_name":"cross-contamination","score":0.6850000023841858},{"id":"https://openalex.org/keywords/lung-water","display_name":"lung water","score":0.5540000200271606},{"id":"https://openalex.org/keywords/lung-compliance","display_name":"lung compliance","score":0.7570000290870667},{"id":"https://openalex.org/keywords/pulmonary-endothelium","display_name":"pulmonary endothelium","score":0.859000027179718},{"id":"https://openalex.org/keywords/lung-tumor-resection","display_name":"lung tumor resection","score":0.6800000071525574},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8975520133972168},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.7563717365264893},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6283619403839111},{"id":"https://openalex.org/C2778074680","wikidata":"https://www.wikidata.org/wiki/Q2125439","display_name":"Cannula","level":2,"score":0.5978062152862549},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.511237621307373},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.4957088232040405},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4848531484603882},{"id":"https://openalex.org/C2778847313","wikidata":"https://www.wikidata.org/wiki/Q1340337","display_name":"Thoracotomy","level":2,"score":0.44261249899864197},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.40379461646080017},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3315412700176239},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.31708070635795593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2762361466884613}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006324","descriptor_name":"Heart Arrest, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008170","descriptor_name":"Lung Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010478","descriptor_name":"Chemotherapy, Cancer, Regional Perfusion","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010478","descriptor_name":"Chemotherapy, Cancer, Regional Perfusion","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011652","descriptor_name":"Pulmonary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:4012605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4012605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"mag:33085757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4012605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1993986769","https://openalex.org/W2009593167","https://openalex.org/W1531083786","https://openalex.org/W2154608911","https://openalex.org/W1981711832","https://openalex.org/W1965802234","https://openalex.org/W1991276398","https://openalex.org/W2052894538","https://openalex.org/W2606513998","https://openalex.org/W2071549499","https://openalex.org/W2095447519","https://openalex.org/W2011950935","https://openalex.org/W2065338378","https://openalex.org/W2038053631","https://openalex.org/W2469555883","https://openalex.org/W2070487917","https://openalex.org/W2806285688","https://openalex.org/W2150487985","https://openalex.org/W2191219754","https://openalex.org/W2067064694","https://openalex.org/W2027395744","https://openalex.org/W2782689871","https://openalex.org/W2800186514","https://openalex.org/W2572899914","https://openalex.org/W2335906830","https://openalex.org/W2066404900","https://openalex.org/W2169008732","https://openalex.org/W2113278680","https://openalex.org/W2804490645","https://openalex.org/W2298418948","https://openalex.org/W2034442000","https://openalex.org/W2157395284","https://openalex.org/W2110386073","https://openalex.org/W2135817940","https://openalex.org/W2319831517","https://openalex.org/W2854145802","https://openalex.org/W2119099287","https://openalex.org/W2147246240","https://openalex.org/W2024014530","https://openalex.org/W2339774970","https://openalex.org/W1994740077","https://openalex.org/W2142099365","https://openalex.org/W2049882979","https://openalex.org/W2424625022","https://openalex.org/W2136628513","https://openalex.org/W2069612491","https://openalex.org/W2050169742","https://openalex.org/W2077945404","https://openalex.org/W2910674286","https://openalex.org/W1982822355","https://openalex.org/W2149787043","https://openalex.org/W2808915347","https://openalex.org/W2802589270","https://openalex.org/W1987962683","https://openalex.org/W2098166849","https://openalex.org/W2331613581","https://openalex.org/W2620804057","https://openalex.org/W2563723939","https://openalex.org/W1986572043","https://openalex.org/W2140472738","https://openalex.org/W2010326322","https://openalex.org/W2149768129","https://openalex.org/W2103935957","https://openalex.org/W1490240498","https://openalex.org/W1970701525","https://openalex.org/W2150680216","https://openalex.org/W2314283002","https://openalex.org/W2096036897","https://openalex.org/W2338693134","https://openalex.org/W2151686058","https://openalex.org/W2024927918","https://openalex.org/W2897902093","https://openalex.org/W2773047201","https://openalex.org/W2946882253","https://openalex.org/W2904609170","https://openalex.org/W2566053885","https://openalex.org/W2979944310","https://openalex.org/W2614273416","https://openalex.org/W2015969861","https://openalex.org/W2154360891"],"related_works":["https://openalex.org/W2507834112","https://openalex.org/W2145357644","https://openalex.org/W2344981287","https://openalex.org/W4251268512","https://openalex.org/W2152754496","https://openalex.org/W2401135491","https://openalex.org/W2346843702","https://openalex.org/W1998689533","https://openalex.org/W2359483300","https://openalex.org/W2425603675"],"abstract_inverted_index":{"The":[0,41,220],"objectives":[1],"of":[2,24,33,55,133,182,202,214,237,247],"this":[3],"study":[4,218],"were":[5],"to":[6,29,72,114,156,243],"develop":[7],"a":[8,22,67,148,235],"surgical":[9,43],"procedure":[10,35,44,221],"that":[11,45,142,163],"would":[12],"allow":[13],"for":[14],"bilateral":[15],"isolated":[16,183],"lung":[17,166,184,190,230,251],"perfusion":[18,58,96,231],"in":[19,49,90,100,116],"vivo":[20],"as":[21],"means":[23],"delivering":[25,238],"organ-specific":[26],"chemotherapy":[27,152,242],"and":[28,86,111,125,172,193,232],"evaluate":[30],"the":[31,34,52,74,82,91,121,126,138,157,203,212,215,226],"influence":[32],"on":[36],"certain":[37],"pulmonary":[38,84,134,158,168],"physiologic":[39],"parameters.":[40],"sterile":[42],"was":[46,65,70,98,112,123],"carried":[47],"out":[48],"dogs":[50],"involved":[51],"setting":[53],"up":[54],"two":[56],"separate":[57],"circuits.":[59],"Once":[60],"standard":[61],"systemic":[62,139,143],"cardiopulmonary":[63],"bypass":[64],"established,":[66],"second":[68],"circuit":[69],"devised":[71],"perfuse":[73],"lungs":[75],"by":[76,211],"placing":[77],"an":[78,117],"inflow":[79],"cannula":[80],"into":[81,137],"main":[83],"artery":[85],"collecting":[87],"venous":[88],"effluent":[89],"left":[92],"atrium.":[93],"Cross-contamination":[94],"between":[95],"circuits":[97],"determined":[99],"acute":[101],"studies":[102,161],"with":[103,245],"labeled":[104],"plasma":[105],"protein":[106],"or":[107,249],"red":[108],"blood":[109],"cells":[110],"found":[113],"be":[115,147],"acceptable":[118],"range":[119],"if":[120],"aorta":[122],"cross-clamped":[124],"heart":[127],"arrested.":[128],"Only":[129],"about":[130],"0.4":[131],"ml/min":[132],"perfusate":[135],"leaked":[136],"circulation,":[140],"indicating":[141],"toxicity":[144],"should":[145],"not":[146],"major":[149],"concern":[150],"when":[151],"agents":[153],"are":[154],"added":[155],"perfusate.":[159],"Chronic":[160],"demonstrated":[162],"hemodynamic":[164],"parameters,":[165],"water,":[167],"endothelial":[169],"serotonin":[170,195],"extraction,":[171],"histologic":[173],"findings":[174],"all":[175,201],"showed":[176,197],"minimal":[177],"changes":[178],"after":[179,188],"50":[180],"minutes":[181],"perfusion.":[185],"Five":[186],"days":[187],"perfusion,":[189],"dynamic":[191],"compliance":[192],"peak":[194],"extraction":[196],"significant":[198,223],"decreases.":[199],"However,":[200],"measured":[204],"parameters":[205],"had":[206],"returned":[207],"toward":[208],"baseline":[209],"levels":[210],"end":[213],"8-week":[216],"postoperative":[217],"period.":[219],"offers":[222],"advantages":[224],"over":[225],"previously":[227],"described":[228],"single":[229],"may":[233],"provide":[234],"method":[236],"immediate":[239],"high-concentration":[240],"adjuvant":[241],"coincide":[244],"resection":[246],"primary":[248],"metastatic":[250],"tumors.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}