{"id":"https://openalex.org/W33084163","doi":null,"title":"The involvement of phosphoinositide 3-kinase in murine lung branching morphogenesis and insights into protein mediated drug delivery","display_name":"The involvement of phosphoinositide 3-kinase in murine lung branching morphogenesis and insights into protein mediated drug delivery","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W33084163","mag":"33084163"},"language":"en","primary_location":{"id":"pmh:oai:opus.bath.ac.uk:40793","doi":null,"is_oa":false,"landing_page_url":"http://opus.bath.ac.uk/40793/1/The_Involvement_of_Phosphoinositide_3_kinase_in_Murine_Lung_Branching_Morphogenesis_and_Insights_into_Protein_mediated_Drug_Delivery.pdf","pdf_url":"http://opus.bath.ac.uk/40793/1/The_Involvement_of_Phosphoinositide_3_kinase_in_Murine_Lung_Branching_Morphogenesis_and_Insights_into_Protein_mediated_Drug_Delivery.pdf","source":{"id":"https://openalex.org/S4306401631","display_name":"The University of Bath Online Publications Store (The University of Bath)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51601045","host_organization_name":"University of Bath","host_organization_lineage":["https://openalex.org/I51601045"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064198705","display_name":"Edward P. Carter","orcid":"https://orcid.org/0000-0003-4499-1101","observed_orcids":["https://orcid.org/0000-0003-4499-1101"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Edward Carter","raw_affiliation_strings":["Department of Pharmacy & Pharmacology"],"raw_orcid":"https://orcid.org/0000-0003-4499-1101","affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064198705"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.13429999351501465,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.07090000063180923,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lung-branching-morphogenesis","display_name":"lung branching morphogenesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/embryonic-lung-development","display_name":"embryonic lung development","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pi3kalpha-inhibition","display_name":"PI3K\u03b1 inhibition","score":0.9269999861717224},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fibroblast-growth-factor-7","display_name":"fibroblast growth factor 7","score":0.9350000023841858},{"id":"https://openalex.org/keywords/lung-epithelium","display_name":"lung epithelium","score":0.7639999985694885},{"id":"https://openalex.org/keywords/cell-penetrating-peptides","display_name":"cell-penetrating peptides","score":0.9070000052452087},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.7580000162124634},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bacterial-toxins","display_name":"bacterial toxins","score":0.6420000195503235},{"id":"https://openalex.org/keywords/pseudomonas-exotoxin-a","display_name":"Pseudomonas exotoxin A","score":0.9769999980926514},{"id":"https://openalex.org/keywords/gm1-ganglioside","display_name":"GM1 ganglioside","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.6919999718666077},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.878000020980835},{"id":"https://openalex.org/keywords/transcytosis","display_name":"transcytosis","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7506068348884583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6802516579627991},{"id":"https://openalex.org/C2781322055","wikidata":"https://www.wikidata.org/wiki/Q423725","display_name":"Phosphoinositide 3-kinase","level":4,"score":0.6769692897796631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5680935978889465},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5314703583717346},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.48425576090812683},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.47052088379859924},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4045795798301697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.327786386013031},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32744187116622925},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1183953583240509},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11188435554504395}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:opus.bath.ac.uk:40793","doi":null,"is_oa":false,"landing_page_url":"http://opus.bath.ac.uk/40793/1/The_Involvement_of_Phosphoinositide_3_kinase_in_Murine_Lung_Branching_Morphogenesis_and_Insights_into_Protein_mediated_Drug_Delivery.pdf","pdf_url":"http://opus.bath.ac.uk/40793/1/The_Involvement_of_Phosphoinositide_3_kinase_in_Murine_Lung_Branching_Morphogenesis_and_Insights_into_Protein_mediated_Drug_Delivery.pdf","source":{"id":"https://openalex.org/S4306401631","display_name":"The University of Bath Online Publications Store (The University of Bath)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51601045","host_organization_name":"University of Bath","host_organization_lineage":["https://openalex.org/I51601045"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:33084163","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619235","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W65377277","https://openalex.org/W2132273917","https://openalex.org/W2794654412","https://openalex.org/W2597094898","https://openalex.org/W2151025953","https://openalex.org/W2135588950","https://openalex.org/W2154365512","https://openalex.org/W2123935944","https://openalex.org/W2944363327","https://openalex.org/W2775794080","https://openalex.org/W842510386","https://openalex.org/W2886865853","https://openalex.org/W2138280644","https://openalex.org/W2790951879","https://openalex.org/W2552256341","https://openalex.org/W2887420502","https://openalex.org/W2178188459","https://openalex.org/W1977358116","https://openalex.org/W3000989170","https://openalex.org/W2895528533"],"related_works":["https://openalex.org/W7096199647","https://openalex.org/W2116886973","https://openalex.org/W4281389214","https://openalex.org/W2044927450","https://openalex.org/W1985799576","https://openalex.org/W2162525343","https://openalex.org/W1974455711","https://openalex.org/W2164210289","https://openalex.org/W7096556568","https://openalex.org/W2059870548"],"abstract_inverted_index":{"Epithelial":[0],"branching":[1,55,94,108,136],"morphogenesis":[2],"is":[3,298,316],"a":[4,31,44,100,132,135,148,169,176,207,224],"critical":[5],"step":[6],"in":[7,33,53,105,233,336],"the":[8,15,18,23,34,41,48,54,58,71,93,106,118,152,173,211,241,272,289,295,302,308,337],"development":[9],"of":[10,22,43,57,64,75,86,96,112,121,150,154,175,205,213,226,243,263,274,294,300,305,326],"many":[11,181],"epithelial":[12,214],"organs":[13],"including":[14],"lungs":[16,67],"and":[17,83,188,229,257,266,329],"salivary":[19],"glands.":[20],"Many":[21],"signalling":[24,80],"pathways":[25],"that":[26,68,164,180,288,314],"orchestrate":[27],"this":[28],"process":[29],"show":[30],"resurgence":[32],"diseased":[35],"state.":[36],"We":[37,60,138,238,283],"sought":[38,191],"to":[39,90,116,134,146,167,192,270,286,307,318],"determine":[40,193],"role":[42,102],"common":[45,195],"disease":[46],"pathway,":[47,52],"phosphoinositide":[49],"3-kinase":[50],"(PI3K)":[51],"program":[56],"lung.":[59],"utilised":[61],"ex-vivo":[62],"cultures":[63],"embryonic":[65,97],"murine":[66,128],"best":[69],"recapitulates":[70],"developmental":[72],"process.":[73],"Inhibition":[74],"PI3K\u03b1,":[76],"or":[77,235,277],"its":[78],"downstream":[79],"components":[81],"Akt":[82],"mammalian":[84],"target":[85],"rapamycin,":[87],"was":[88,114],"able":[89,166,285,317],"greatly":[91],"enhance":[92],"potential":[95,242],"lungs,":[98],"implying":[99],"negative":[101],"for":[103,247],"PI3K":[104,113,155],"lung":[107,129],"morphogenesis.":[109],"Moreover":[110],"inhibition":[111],"sufficient":[115],"alter":[117],"morphogenic":[119],"properties":[120],"fibroblast":[122],"growth":[123],"factor":[124],"7":[125],"on":[126],"isolated":[127],"epithelium":[130],"from":[131,185],"cystic":[133],"response.":[137,201],"also":[139],"investigated":[140],"protein":[141,208],"mediated":[142],"drug":[143,170],"delivery":[144,153],"tools":[145],"provide":[147],"means":[149],"enhancing":[151,301],"based":[156],"therapeutics.":[157],"Cell-penetrating":[158],"peptides":[159],"(CPPs)":[160],"are":[161,165,183,260],"small":[162],"proteins":[163,187],"transport":[168,304,319],"cargo":[171,209,322,332],"across":[172,280,323],"membrane":[174],"cell.":[177],"However,":[178],"given":[179],"CPPs":[182,196,202],"derived":[184],"viral":[186],"venoms":[189],"we":[190,203,312],"if":[194],"could":[197],"induce":[198],"an":[199,218,320],"immune":[200,219],"capable":[204,262,299],"delivering":[206],"into":[210,333],"interior":[212],"cells":[215,265,328,334],"without":[216],"inducing":[217],"response":[220],"as":[221],"measured":[222],"by":[223],"lack":[225],"NF\u03baB":[227],"activation":[228],"no":[230],"observable":[231],"increase":[232],"interleukin-6":[234],"-8":[236],"secretion.":[237],"finally":[239],"explored":[240],"repurposing":[244],"bacterial":[245],"toxins":[246,251],"therapeutic":[248],"applications.":[249],"The":[250],"Pseudomonas":[252],"aeruginosa":[253],"exotoxin":[254],"A":[255],"(PEx)":[256],"Cholix":[258],"(Chx)":[259],"natively":[261],"entering":[264],"subsequently":[267],"being":[268],"transported":[269],"either":[271],"cytoplasm":[273],"non-polarised":[275],"cells,":[276],"undergoing":[278],"transcytosis":[279],"polarised":[281,324],"cells.":[282],"were":[284],"identify":[287],"C16:1":[290],"ceramide":[291],"chain":[292],"variant":[293],"ganglioside":[296],"GM1":[297],"intracellular":[303],"PEx":[306,315],"Golgi":[309],"network.":[310],"Moreover,":[311],"demonstrated":[313],"siRNA":[321],"monolayers":[325],"Caco-2":[327],"deliver":[330],"said":[331],"present":[335],"basolateral":[338],"compartment.":[339]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
