{"id":"https://openalex.org/W330485178","doi":null,"title":"[Primary and acquired resistance to antituberculous drugs in strains of Mycobacterium tuberculosis isolated in Rwanda].","display_name":"[Primary and acquired resistance to antituberculous drugs in strains of Mycobacterium tuberculosis isolated in Rwanda].","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W330485178","mag":"330485178","pmid":"https://pubmed.ncbi.nlm.nih.gov/17691433"},"language":"fr","primary_location":{"id":"pmid:17691433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17691433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medecine tropicale : revue du Corps de sante colonial","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103649823","display_name":"A N Umubyeyi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087849","display_name":"University of Rwanda","ror":"https://ror.org/00286hs46","country_code":"RW","type":"education","lineage":["https://openalex.org/I4210087849"]}],"countries":["RW"],"is_corresponding":false,"raw_author_name":"A N Umubyeyi","raw_affiliation_strings":["L'Unit\u00e9 de Mycobact\u00e9riologie de l'Institut de M\u00e9decine Tropicale, Universit\u00e9 Nationale du Rwanda. alainenyaruhirira@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L'Unit\u00e9 de Mycobact\u00e9riologie de l'Institut de M\u00e9decine Tropicale, Universit\u00e9 Nationale du Rwanda. alainenyaruhirira@hotmail.com","institution_ids":["https://openalex.org/I4210087849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033438385","display_name":"Leen Rigouts","orcid":"https://orcid.org/0000-0003-3301-9480","observed_orcids":["https://orcid.org/0000-0003-3301-9480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Rigouts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055947703","display_name":"Georges Zissis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Zissis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034902691","display_name":"Eliane Kamanzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Kamanzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066440566","display_name":"P Pauwels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Pauwels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084259440","display_name":"Michel Gasana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Gasana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019175428","display_name":"Greet Vandebriel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Vandebriel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043496834","display_name":"Marc Jean Struelens","orcid":"https://orcid.org/0000-0001-5150-4944","observed_orcids":["https://orcid.org/0000-0001-5150-4944"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Struelens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111805619","display_name":"Fran\u00e7oise Portaels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Portaels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2118,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.56373314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"67","issue":"2","first_page":"149","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-resistant-tuberculosis","display_name":"drug-resistant tuberculosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/primary-drug-resistance","display_name":"primary drug resistance","score":0.9760000109672546},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.843999981880188},{"id":"https://openalex.org/keywords/pulmonary-tuberculosis","display_name":"pulmonary tuberculosis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/hiv-coinfection","display_name":"HIV coinfection","score":0.8519999980926514},{"id":"https://openalex.org/keywords/streptomycin-resistance","display_name":"streptomycin resistance","score":0.828000009059906},{"id":"https://openalex.org/keywords/ethambutol-resistance","display_name":"ethambutol resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rwanda","display_name":"Rwanda","score":0.4569999873638153},{"id":"https://openalex.org/keywords/tuberculosis-surveillance","display_name":"tuberculosis surveillance","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8661340475082397},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.7059335112571716},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5264609456062317},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5055723190307617},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.46069690585136414},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.14736565947532654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.04604959487915039}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012432","descriptor_name":"Rwanda","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019233","descriptor_name":"Retreatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmid:17691433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17691433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medecine tropicale : revue du Corps de sante colonial","raw_type":"English Abstract"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/84393","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/84393","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine tropicale, 67 (2","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2408173403","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17691433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3142205465","doi":null,"is_oa":false,"landing_page_url":"https://bdsp-ehesp.inist.fr/vibad/index.php?action=getRecordDetail&idt=361922","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:330485178","doi":null,"is_oa":false,"landing_page_url":"https://difusion.ulb.ac.be/vufind/Record/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/84393/Details","pdf_url":null,"source":{"id":"https://openalex.org/S4306519440","display_name":"M\u00e9decine Tropicale","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"M\u00e9decine tropicale","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2051731467","https://openalex.org/W2082959484","https://openalex.org/W6902520518","https://openalex.org/W1820342512","https://openalex.org/W4300926894","https://openalex.org/W2496765242","https://openalex.org/W1984733401","https://openalex.org/W2414653838","https://openalex.org/W2555003979","https://openalex.org/W2072602769"],"abstract_inverted_index":{"This":[0,180],"study":[1,181],"was":[2,35,68,87,97,130,147,153,169,200],"undertaken":[3],"within":[4],"the":[5,12,38,102,154,184],"framework":[6],"of":[7,14,24,30,40,45,54,65,101,108,111,141,167,186,218],"a":[8,27,90],"surveillance":[9],"project":[10],"on":[11,78],"resistance":[13,44,121,143,160,190],"Mycobacterium":[15],"tuberculosis":[16,31,47,96],"to":[17,36,48,84,122,144,151,161,191,213],"first-line":[18,192],"antituberculosis":[19,50,85,128,145,193],"drugs":[20,86,129,146,194],"in":[21,99,132],"four":[22,127],"provinces":[23],"Rwanda":[25],"with":[26,57,171,202],"high":[28,196],"prevalence":[29,39,140],"(TB).":[32],"The":[33,139,164,205],"purpose":[34],"determine":[37],"primary":[41,187],"and":[42,80,136,176,188,197,216,220],"acquired":[43,142,189],"M.":[46,95],"major":[49],"drugs.":[51],"A":[52,106],"cohort":[53],"patients":[55,104],"(n=710)":[56],"pulmonary":[58],"TB":[59,199,207,219],"documented":[60],"by":[61,159],"positive":[62],"microscopic":[63],"examinations":[64],"exhaustive":[66],"samples":[67,75],"recruited":[69],"at":[70],"7":[71],"treatment":[72],"centers.":[73],"Sputum":[74],"were":[76,118,195],"cultured":[77],"L\u00f6wenstein-Jensen":[79],"Coletsos":[81],"media.":[82],"Sensitivity":[83],"tested":[88,113],"using":[89],"BACTEC":[91],"460":[92],"radiometric":[93],"system.":[94],"isolated":[98],"644":[100],"710":[103],"(90.7%).":[105],"total":[107],"296":[109],"out":[110],"573":[112],"for":[114],"HIV":[115,203,221],"infection":[116],"(51.7%)":[117],"positive.":[119],"Primary":[120,149],"one,":[123],"two,":[124],"three":[125],"or":[126],"observed":[131],"3.5%,":[133],"2.9%,":[134],"1.4%":[135],"5.7%":[137],"respectively.":[138],"11.2%.":[148],"monoresistance":[150],"streptomycin":[152],"most":[155],"prevalent":[156],"(2.3%)":[157],"followed":[158],"ethambutol":[162],"(1%).":[163],"combined":[165],"rate":[166],"multiresistance":[168],"11.6%":[170],"7%":[172],"involving":[173,178],"new":[174],"cases":[175],"25.5%":[177],"retreatment.":[179],"showed":[182],"that":[183,198],"rates":[185],"associated":[201],"infection.":[204,222],"National":[206],"Control":[208],"Program":[209],"must":[210],"implement":[211],"measures":[212],"coordinate":[214],"diagnosis":[215],"management":[217]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}