{"id":"https://openalex.org/W330245850","doi":null,"title":"Understanding the Regulation of Metabolic Enzyme Acetylation in E. Coli","display_name":"Understanding the Regulation of Metabolic Enzyme Acetylation in E. Coli","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W330245850","mag":"330245850"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.luc.edu:luc_theses-1838","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_theses/839","pdf_url":"https://ecommons.luc.edu/luc_theses/839","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ecommons.luc.edu/luc_theses/839","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038422966","display_name":"Arti Walker\u2010Peddakotla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arti Walker\u2010Peddakotla","raw_affiliation_strings":["#N#        Loyola University, Chicago"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"#N#        Loyola University, Chicago","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038422966"],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12688","display_name":"Microbial metabolism and enzyme function","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-acetylation","display_name":"protein acetylation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8790000081062317},{"id":"https://openalex.org/keywords/camp-receptor-protein","display_name":"cAMP receptor protein","score":0.9520000219345093},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.7870000004768372},{"id":"https://openalex.org/keywords/pat","display_name":"PAT","score":0.5680000185966492},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/central-carbon-metabolism","display_name":"central carbon metabolism","score":0.7229999899864197},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gluconeogenesis","display_name":"gluconeogenesis","score":1.0},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.8347817063331604},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.8125125169754028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5101309418678284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48355743288993835},{"id":"https://openalex.org/C2910274206","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferases","level":4,"score":0.4556141793727875},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41225284337997437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3276136815547943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2493833303451538}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.luc.edu:luc_theses-1838","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_theses/839","pdf_url":"https://ecommons.luc.edu/luc_theses/839","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},{"id":"mag:330245850","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.luc.edu/cgi/viewcontent.cgi?article=1838&context=luc_theses","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.luc.edu:luc_theses-1838","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.luc.edu/luc_theses/839","pdf_url":"https://ecommons.luc.edu/luc_theses/839","source":{"id":"https://openalex.org/S4306402030","display_name":"Loyola eCommons (Loyola University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1925986","host_organization_name":"Loyola University Chicago","host_organization_lineage":["https://openalex.org/I1925986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Master's Theses","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W330245850.pdf","grobid_xml":"https://content.openalex.org/works/W330245850.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W91379014","https://openalex.org/W93718454","https://openalex.org/W191474238","https://openalex.org/W209744592","https://openalex.org/W623445268","https://openalex.org/W836553960","https://openalex.org/W1485808785","https://openalex.org/W1487037005","https://openalex.org/W1501390529","https://openalex.org/W1510507516","https://openalex.org/W1512374553","https://openalex.org/W1517551696","https://openalex.org/W1520001214","https://openalex.org/W1520448658","https://openalex.org/W1523248897","https://openalex.org/W1531828321","https://openalex.org/W1548772486","https://openalex.org/W1555898673","https://openalex.org/W1578248564","https://openalex.org/W1578261346","https://openalex.org/W1595014784","https://openalex.org/W1606734725","https://openalex.org/W1607751721","https://openalex.org/W1648306972","https://openalex.org/W1838466051","https://openalex.org/W1844005403","https://openalex.org/W1931147290","https://openalex.org/W1939754288","https://openalex.org/W1940645698","https://openalex.org/W1955508206","https://openalex.org/W1966614672","https://openalex.org/W1969899640","https://openalex.org/W1970177142","https://openalex.org/W1971729222","https://openalex.org/W1972806004","https://openalex.org/W1974089302","https://openalex.org/W1975692560","https://openalex.org/W1980472460","https://openalex.org/W1980747723","https://openalex.org/W1984481954","https://openalex.org/W1989075680","https://openalex.org/W1991102189","https://openalex.org/W1992552599","https://openalex.org/W1993436205","https://openalex.org/W1993463858","https://openalex.org/W1994782227","https://openalex.org/W1995042750","https://openalex.org/W1999607293","https://openalex.org/W2001721950","https://openalex.org/W2001769819","https://openalex.org/W2001903625","https://openalex.org/W2009826707","https://openalex.org/W2009841923","https://openalex.org/W2009929728","https://openalex.org/W2010480471","https://openalex.org/W2013617142","https://openalex.org/W2014889718","https://openalex.org/W2017117976","https://openalex.org/W2017702083","https://openalex.org/W2018684976","https://openalex.org/W2018711046","https://openalex.org/W2019653890","https://openalex.org/W2025827248","https://openalex.org/W2027575596","https://openalex.org/W2028275878","https://openalex.org/W2029130907","https://openalex.org/W2032088085","https://openalex.org/W2034614265","https://openalex.org/W2035333716","https://openalex.org/W2036449301","https://openalex.org/W2036874847","https://openalex.org/W2040199933","https://openalex.org/W2044973253","https://openalex.org/W2045751326","https://openalex.org/W2050373816","https://openalex.org/W2051001876","https://openalex.org/W2056390565","https://openalex.org/W2059473902","https://openalex.org/W2063227009","https://openalex.org/W2064921878","https://openalex.org/W2065896831","https://openalex.org/W2066989142","https://openalex.org/W2068353202","https://openalex.org/W2069430143","https://openalex.org/W2069826477","https://openalex.org/W2075747312","https://openalex.org/W2077263483","https://openalex.org/W2080180276","https://openalex.org/W2080688660","https://openalex.org/W2082926307","https://openalex.org/W2083319498","https://openalex.org/W2085836949","https://openalex.org/W2085872107","https://openalex.org/W2086251375","https://openalex.org/W2086377767","https://openalex.org/W2087714970","https://openalex.org/W2091457094","https://openalex.org/W2093891151","https://openalex.org/W2094531949","https://openalex.org/W2094685393","https://openalex.org/W2095235693","https://openalex.org/W2095965814","https://openalex.org/W2107272621","https://openalex.org/W2107870682","https://openalex.org/W2108848183","https://openalex.org/W2110247981","https://openalex.org/W2111612750","https://openalex.org/W2111967267","https://openalex.org/W2112351720","https://openalex.org/W2112389202","https://openalex.org/W2119952650","https://openalex.org/W2120469353","https://openalex.org/W2121012122","https://openalex.org/W2121956021","https://openalex.org/W2121972901","https://openalex.org/W2124869787","https://openalex.org/W2126017684","https://openalex.org/W2127811150","https://openalex.org/W2127936263","https://openalex.org/W2131233236","https://openalex.org/W2132552660","https://openalex.org/W2135871119","https://openalex.org/W2136773773","https://openalex.org/W2138457121","https://openalex.org/W2141093436","https://openalex.org/W2142256183","https://openalex.org/W2144495216","https://openalex.org/W2147189708","https://openalex.org/W2149743007","https://openalex.org/W2150512017","https://openalex.org/W2150688068","https://openalex.org/W2152875113","https://openalex.org/W2153399774","https://openalex.org/W2156153424","https://openalex.org/W2160902874","https://openalex.org/W2163433435","https://openalex.org/W2164125862","https://openalex.org/W2166555234","https://openalex.org/W2172187729","https://openalex.org/W2201187771","https://openalex.org/W2231318093","https://openalex.org/W2315836211","https://openalex.org/W2319456258"],"related_works":["https://openalex.org/W2121972901","https://openalex.org/W2899658543","https://openalex.org/W1899091258","https://openalex.org/W2765663455","https://openalex.org/W3033823933","https://openalex.org/W2896516937","https://openalex.org/W7125963528","https://openalex.org/W2124869787","https://openalex.org/W1500015504","https://openalex.org/W3210260070"],"abstract_inverted_index":{"Global":[0],"protein":[1,59,62,71,95,159,173,291],"acetylation":[2,26,63,72,96,116,257,322],"is":[3,39],"a":[4,29,99,122,143,158,162,181,225,230,240,246,294],"newly":[5],"discovered":[6],"phenomenon":[7],"in":[8,17,64,85,98,203],"bacteria.":[9],"Of":[10],"the":[11,42,56,74,105,149,155,172,194,251,268,304,324],"more":[12],"than":[13],"250":[14],"acetylations":[15,46],"reported":[16],"E.":[18,65],"coli,":[19],"many":[20],"are":[21,327],"of":[22,33,44,48,76,104,113,157,171,262,296],"metabolic":[23,34,50,110,297],"enzymes.":[24,111],"Thus,":[25],"could":[27,199,215],"represent":[28],"novel":[30],"posttranslational":[31],"mechanism":[32,182],"control.":[35],"Yet,":[36],"almost":[37],"nothing":[38],"known":[40,177],"about":[41],"regulation":[43],"these":[45],"or":[47],"their":[49,300],"outcomes.":[51],"Here,":[52],"we":[53,82,211,222],"report":[54,164],"that":[55,70,125,151,166,183,192,196,224,249,285,313],"cAMP":[57],"receptor":[58],"(CRP)":[60],"regulates":[61,209],"coli":[66],"and":[67,92,102,239,275,302,308],"provide":[68],"evidence":[69,191],"modulates":[73],"flux":[75],"carbon":[77,237,247],"through":[78],"central":[79,109],"metabolism.":[80,217],"When":[81],"grew":[83],"cells":[84],"mixed":[86],"amino":[87],"acids":[88],"supplemented":[89],"with":[90,130],"glucose":[91],"cAMP,":[93],"global":[94],"increased":[97],"CRP-dependent":[100,325],"manner":[101],"several":[103],"acetylated":[106],"proteins":[107],"were":[108,267],"Much":[112],"this":[114,321],"CRP-mediated":[115],"required":[117],"activation":[118],"region":[119],"1":[120],"(AR1),":[121],"surface":[123,135],"patch":[124,136],"allows":[126],"CRP":[127,152,167,197,208,280,286],"to":[128,142,318],"interact":[129],"RNA":[131],"polymerase.":[132],"A":[133],"second":[134],"(AR2)":[137],"also":[138,198],"was":[139,279],"involved,":[140],"albeit":[141],"lesser":[144],"degree.":[145],"These":[146],"results":[147],"raise":[148],"possibility":[150],"might":[153,168],"regulate":[154,169,200],"transcription":[156,170,202],"acetyltransferase.":[160],"Indeed,":[161],"recent":[163],"suggested":[165],"acetyltransferase":[174],"YfiQ":[175,214,265,314],"(also":[176],"as":[178],"Pat)":[179],"by":[180],"would":[184],"require":[185],"AR2.":[186],"We":[187,282,310],"further":[188,311],"obtained":[189],"bioinformatic":[190],"supports":[193],"hypothesis":[195],"yfiQ":[201,226,288],"an":[204],"AR1-dependent":[205],"manner.":[206],"Since":[207],"metabolism,":[210],"asked":[212],"if":[213],"influence":[216],"Using":[218],"Phenotype":[219],"MicroArray\uf8ea":[220],"analysis,":[221],"found":[223],"null":[227],"mutant":[228],"exhibits":[229],"distinctive":[231],"defect":[232],"during":[233,243],"growth":[234,244],"on":[235,245],"gluconeogenic":[236],"sources":[238],"distinct":[241],"advantage":[242],"source":[248],"bypasses":[250],"need":[252],"for":[253],"gluconeogenesis.":[254,309],"In":[255],"vitro":[256],"assays":[258],"identified":[259],"four":[260],"substrates":[261,266],"YfiQ.":[263],"Three":[264],"strictly":[269],"irreversible":[270],"glycolytic":[271],"enzymes":[272],"PfkA,":[273],"PfkB,":[274],"LpdA.":[276],"The":[277],"fourth":[278],"itself.":[281],"thus":[283],"hypothesize":[284],"activates":[287],"transcription,":[289],"whose":[290],"product":[292],"acetylates":[293,315],"subset":[295],"enzymes,":[298],"altering":[299],"function":[301],"shifting":[303],"balance":[305],"between":[306],"glycolysis":[307],"propose":[312],"CRP.":[316],"Efforts":[317],"determine":[319],"how":[320],"affects":[323],"transcriptome":[326],"underway.":[328]},"counts_by_year":[],"updated_date":"2026-09-16T18:09:00.828671","created_date":"2016-06-24T00:00:00"}
