{"id":"https://openalex.org/W32963192","doi":null,"title":"Cell biology of valvular interstitial cells.","display_name":"Cell biology of valvular interstitial cells.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W32963192","mag":"32963192","pmid":"https://pubmed.ncbi.nlm.nih.gov/8624972"},"language":"en","primary_location":{"id":"pmid:8624972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8624972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111597503","display_name":"MSc Diane L Mulholland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D L Mulholland","raw_affiliation_strings":["Vascular Research Laboratory, Department of Pathology, Toronto Hospital Research Institute, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Research Laboratory, Department of Pathology, Toronto Hospital Research Institute, Ontario, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109251908","display_name":"A I Gotlieb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A I Gotlieb","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2924,"has_fulltext":false,"cited_by_count":181,"citation_normalized_percentile":{"value":0.57192887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"231","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valvular-interstitial-cells","display_name":"valvular interstitial cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/heart-valves","display_name":"heart valves","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitral-valve","display_name":"mitral valve","score":0.8140000104904175},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cell-heterogeneity","display_name":"cellular heterogeneity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fibroblast-phenotype","display_name":"fibroblast phenotype","score":0.6439999938011169},{"id":"https://openalex.org/keywords/cell-junctions","display_name":"cell junctions","score":0.8389999866485596},{"id":"https://openalex.org/keywords/extracellular-matrix-secretion","display_name":"extracellular matrix secretion","score":0.7870000004768372},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.5199999809265137},{"id":"https://openalex.org/keywords/ultrastructure","display_name":"ultrastructure","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2777534427","wikidata":"https://www.wikidata.org/wiki/Q6057165","display_name":"Interstitial cell","level":2,"score":0.8483256697654724},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.6989619135856628},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.6771500706672668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5810693502426147},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5642708539962769},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.559637188911438},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.554598867893219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5458836555480957},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5076004266738892},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.463661253452301},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29911699891090393},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.250422865152359},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.18010327219963074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10489293932914734}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001021","descriptor_name":"Aortic Valve","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006351","descriptor_name":"Heart Valves","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008858","descriptor_name":"Microscopy, Phase-Contrast","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010784","descriptor_name":"Photomicrography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8624972","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8624972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Journal Article"},{"id":"mag:32963192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8624972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993234518","https://openalex.org/W3152343873","https://openalex.org/W2075517582","https://openalex.org/W2096132697","https://openalex.org/W7097513103","https://openalex.org/W85565993","https://openalex.org/W2172067224","https://openalex.org/W19217443","https://openalex.org/W1979402648","https://openalex.org/W2079312626"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"review":[2,100],"the":[3,7,15,23,45,97,104,147,182],"cell":[4,46,86,116,120,122],"biology":[5,47],"of":[6,10,17,20,48,67,94,103,109,146,149,184],"interstitial":[8,18,27,51,63,112,132,151],"cells":[9,19,28,64,81,95,113,133,152],"heart":[11,21,49,61,110],"valves.":[12,143],"While":[13],"studying":[14],"function":[16,194],"valves,":[22],"authors":[24],"observed":[25],"that":[26,43],"from":[29,41],"porcine":[30],"mitral":[31],"valve":[32,50,62,111,191],"have":[33,65],"mixed":[34],"phenotypic":[35],"expression.":[36],"DATA":[37],"SOURCE:":[38],"English-language":[39],"literature":[40],"1985-95":[42],"discussed":[44],"cells,":[52],"including":[53,114,166],"their":[54],"structural":[55,105],"and":[56,70,106,128,141,173,193,197],"functional":[57,107],"characteristics.":[58],"RESULTS:":[59],"Morphologically,":[60],"characteristics":[66,108],"both":[68,139],"fibroblasts":[69],"smooth":[71,118],"muscle":[72,119],"cells.":[73],"It":[74],"is":[75,153],"not":[76],"clear,":[77],"however,":[78,155],"whether":[79,89],"these":[80],"represent":[82],"a":[83],"single":[84],"(myofibroblast)":[85],"type":[87],"or":[88],"there":[90],"are":[91,177],"two":[92],"populations":[93],"within":[96],"valve.":[98],"This":[99],"summarizes":[101],"reports":[102],"ultrastructure,":[115],"junctions,":[117],"markers,":[121],"growth,":[123],"role":[124,137],"in":[125,138,195],"wound":[126,171],"repair":[127,172],"contractility.":[129,174],"CONCLUSIONS:":[130],"Vascular":[131],"play":[134],"an":[135],"important":[136],"normal":[140],"diseased":[142],"Our":[144],"understanding":[145],"heterogeneity":[148,157,186],"valvular":[150],"incomplete;":[154],"this":[156],"allows":[158],"for":[159],"multiple":[160],"functions":[161],"to":[162,179,190],"be":[163],"carried":[164],"out":[165],"cell-cell":[167],"communication,":[168],"matrix":[169],"secretion,":[170],"Future":[175],"studies":[176],"needed":[178],"focus":[180],"on":[181],"regulation":[183],"cellular":[185],"as":[187],"it":[188],"relates":[189],"structure":[192],"health":[196],"disease.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
