{"id":"https://openalex.org/W32916265","doi":null,"title":"Mechanobiology in the development, maintenance, and degeneration of articular cartilage.","display_name":"Mechanobiology in the development, maintenance, and degeneration of articular cartilage.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W32916265","mag":"32916265","pmid":"https://pubmed.ncbi.nlm.nih.gov/10850820"},"language":"en","primary_location":{"id":"pmid:10850820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of rehabilitation research and development","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049530601","display_name":"Gary S. Beaupr\u00e9","orcid":"https://orcid.org/0000-0002-6211-7621","observed_orcids":["https://orcid.org/0000-0002-6211-7621"]},"institutions":[{"id":"https://openalex.org/I204866599","display_name":"VA Palo Alto Health Care System","ror":"https://ror.org/00nr17z89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I204866599","https://openalex.org/I2799886695","https://openalex.org/I4210125474"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G S Beaupr\u00e9","raw_affiliation_strings":["Rehabilitation Research and Development Center, VA Palo Alto Health Care System, CA 94304, USA. beaupre@bones.stanford.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rehabilitation Research and Development Center, VA Palo Alto Health Care System, CA 94304, USA. beaupre@bones.stanford.edu","institution_ids":["https://openalex.org/I204866599"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S S Stevens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S S Stevens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110014819","display_name":"Dennis R. Professor Carter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D R Carter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3127,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.78325703,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"37","issue":"2","first_page":"145","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.8830000162124634},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cartilage-thickness","display_name":"cartilage thickness","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hydrostatic-pressure","display_name":"hydrostatic pressure","score":0.8619999885559082},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.9929999709129333},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9739999771118164},{"id":"https://openalex.org/keywords/finite-element-model","display_name":"finite element model","score":0.7099999785423279},{"id":"https://openalex.org/keywords/joint-contact-pressure","display_name":"joint contact pressure","score":0.6430000066757202},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.9150000214576721},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9639999866485596},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.8356292843818665},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.8295851945877075},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.7759743928909302},{"id":"https://openalex.org/C2910081258","wikidata":"https://www.wikidata.org/wiki/Q177807","display_name":"Hydrostatic pressure","level":2,"score":0.6444884538650513},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5234474539756775},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.43817609548568726},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.42574116587638855},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38413146138191223},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3806186616420746},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3631242513656616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1937030851840973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16015440225601196},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.12296369671821594},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10850820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of rehabilitation research and development","raw_type":"Journal Article"},{"id":"mag:32916265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10850820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W119579525","https://openalex.org/W570795997","https://openalex.org/W961324200","https://openalex.org/W1497437212","https://openalex.org/W1562926557","https://openalex.org/W1601571585","https://openalex.org/W1797949464","https://openalex.org/W1965766554","https://openalex.org/W1968065996","https://openalex.org/W1973188134","https://openalex.org/W1973771232","https://openalex.org/W1984348097","https://openalex.org/W1984554900","https://openalex.org/W1984621921","https://openalex.org/W1989831107","https://openalex.org/W1990654868","https://openalex.org/W1997914540","https://openalex.org/W1999444272","https://openalex.org/W2001525713","https://openalex.org/W2008786326","https://openalex.org/W2011487877","https://openalex.org/W2012915718","https://openalex.org/W2016717347","https://openalex.org/W2016944916","https://openalex.org/W2018393167","https://openalex.org/W2020316925","https://openalex.org/W2025561101","https://openalex.org/W2025975569","https://openalex.org/W2026143674","https://openalex.org/W2034317727","https://openalex.org/W2036252774","https://openalex.org/W2040142253","https://openalex.org/W2042190017","https://openalex.org/W2043471865","https://openalex.org/W2049610624","https://openalex.org/W2051658684","https://openalex.org/W2054041826","https://openalex.org/W2057713336","https://openalex.org/W2058830496","https://openalex.org/W2059107467","https://openalex.org/W2062094193","https://openalex.org/W2062291041","https://openalex.org/W2073368056","https://openalex.org/W2075935381","https://openalex.org/W2085450161","https://openalex.org/W2090073689","https://openalex.org/W2096362504","https://openalex.org/W2103576580","https://openalex.org/W2111004422","https://openalex.org/W2111632848","https://openalex.org/W2117121868","https://openalex.org/W2120585025","https://openalex.org/W2122319990","https://openalex.org/W2123310132","https://openalex.org/W2142943628","https://openalex.org/W2153747194","https://openalex.org/W2154678665","https://openalex.org/W2155888371","https://openalex.org/W2165678091","https://openalex.org/W2167225984","https://openalex.org/W2178676862","https://openalex.org/W2216796718","https://openalex.org/W2227199707","https://openalex.org/W2266209118","https://openalex.org/W2269768516","https://openalex.org/W2308814985","https://openalex.org/W2335155752","https://openalex.org/W2336315810","https://openalex.org/W2344695725","https://openalex.org/W2408942088","https://openalex.org/W2496305386","https://openalex.org/W2518444239","https://openalex.org/W2532719767","https://openalex.org/W2571109654","https://openalex.org/W2591181672","https://openalex.org/W2592529118","https://openalex.org/W2612019219","https://openalex.org/W2616491039","https://openalex.org/W2751670136","https://openalex.org/W2753944011","https://openalex.org/W2759067728","https://openalex.org/W2765750906","https://openalex.org/W2768399638","https://openalex.org/W2781962980","https://openalex.org/W2788900104","https://openalex.org/W2794723335","https://openalex.org/W2796923356","https://openalex.org/W2800393195","https://openalex.org/W2803802743","https://openalex.org/W2803816031","https://openalex.org/W2804827327","https://openalex.org/W2806194188","https://openalex.org/W2811318498","https://openalex.org/W2883160489","https://openalex.org/W2896424462","https://openalex.org/W2896532738","https://openalex.org/W2896991531","https://openalex.org/W2902061662","https://openalex.org/W2924277568","https://openalex.org/W2940163088","https://openalex.org/W2944179533","https://openalex.org/W2944515601","https://openalex.org/W2948981659","https://openalex.org/W2954169816","https://openalex.org/W2963126670","https://openalex.org/W2966647519","https://openalex.org/W3004692562","https://openalex.org/W3013213051","https://openalex.org/W6740677760","https://openalex.org/W6778287897"],"related_works":["https://openalex.org/W7095167908","https://openalex.org/W2088752908","https://openalex.org/W2076513735","https://openalex.org/W1535378657","https://openalex.org/W2016145855","https://openalex.org/W2090073689","https://openalex.org/W1995304439","https://openalex.org/W2122237923","https://openalex.org/W2418163344","https://openalex.org/W2044939951"],"abstract_inverted_index":{"During":[0],"skeletal":[1],"development,":[2],"the":[3,11,20,65,70,79,85,109,120,179,182,187],"establishment":[4],"of":[5,8,13,22,73,81,87,90,102,122,155,189],"a":[6,38,88,115,128],"layer":[7,89,131],"cartilage":[9,43,60,123,130,147,156,172,195],"at":[10,132],"ends":[12],"long":[14],"bones":[15],"is":[16,51],"intimately":[17],"linked":[18],"to":[19,53,170,194],"process":[21],"endochondral":[23],"ossification.":[24,46,63],"Previous":[25],"in":[26,41,118,126,158,164],"vivo":[27],"studies":[28],"and":[29,45,56,62,76,125,161,197],"computer":[30,98],"models":[31],"suggest":[32],"that":[33,111,137,139,181],"mechanobiological":[34,112,183],"factors":[35,113,184],"can":[36],"play":[37,114],"key":[39,116],"role":[40,117],"modulating":[42],"growth":[44],"Specifically,":[47],"intermittent":[48],"hydrostatic":[49,74],"pressure":[50,75],"thought":[52],"maintain":[54],"cartilage,":[55,92],"shear":[57,77],"stresses":[58],"encourage":[59],"destruction":[61],"In":[64],"present":[66],"investigation":[67],"we":[68],"examined":[69],"combined":[71],"effects":[72],"stress--in":[78],"form":[80],"an":[82,94],"osteogenic":[83],"index--on":[84],"development":[86,188],"articular":[91,165],"using":[93],"idealized":[95],"finite":[96],"element":[97],"model.":[99],"The":[100,134],"results":[101,175],"our":[103],"analyses":[104],"provide":[105],"further":[106],"support":[107],"for":[108,186],"view":[110,180],"regulating":[119],"distribution":[121],"thickness":[124,157],"maintaining":[127],"stable":[129],"maturity.":[133],"model":[135],"predicts":[136],"joints":[138,191],"experience":[140],"higher":[141],"contact":[142],"pressures":[143],"will":[144],"have":[145],"thicker":[146],"layers.":[148],"These":[149,174],"predictions":[150],"are":[151,168,176],"consistent":[152,177],"with":[153,178,200],"observations":[154],"both":[159],"humans":[160],"animals.":[162],"Variations":[163],"mechanical":[166],"load":[167],"predicted":[169],"modulate":[171],"thickness.":[173],"responsible":[185],"diarthrodial":[190],"eventually":[192],"lead":[193],"degeneration":[196],"osteoarthritis":[198],"(OA)":[199],"aging.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
