{"id":"https://openalex.org/W328964562","doi":null,"title":"Reduction of pulmonary toxicity by prednisolone prophylaxis during all-trans retinoic acid treatment of acute promyelocytic leukemia. Australian Leukaemia Study Group.","display_name":"Reduction of pulmonary toxicity by prednisolone prophylaxis during all-trans retinoic acid treatment of acute promyelocytic leukemia. Australian Leukaemia Study Group.","publication_year":1995,"publication_date":"1995-05-01","ids":{"openalex":"https://openalex.org/W328964562","mag":"328964562","pmid":"https://pubmed.ncbi.nlm.nih.gov/7769839"},"language":"en","primary_location":{"id":"pmid:7769839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7769839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008759622","display_name":"James S. Wiley","orcid":"https://orcid.org/0000-0001-9421-4154","observed_orcids":["https://orcid.org/0000-0001-9421-4154"]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"J S Wiley","raw_affiliation_strings":["ALSG Trial Centre, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALSG Trial Centre, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012224975","display_name":"Frank Caleb Firkin","orcid":"https://orcid.org/0000-0002-6419-7813","observed_orcids":["https://orcid.org/0000-0002-6419-7813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F C Firkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3487,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.79708083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"774","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pulmonary-toxicity","display_name":"pulmonary toxicity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/leukocytosis","display_name":"leukocytosis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.8989999890327454},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7279999852180481},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.7905479669570923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7517598867416382},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6967467665672302},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.6276662349700928},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6100730895996094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5924365520477295},{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.5844302773475647},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5688031911849976},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.42320239543914795},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3887394964694977},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.3056657910346985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06550869345664978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015473","descriptor_name":"Leukemia, Promyelocytic, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:7769839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7769839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Clinical Trial"},{"id":"pmh:oai:ecite.utas.edu.au:6230","doi":null,"is_oa":false,"landing_page_url":"http://ecite.utas.edu.au/6230","pdf_url":null,"source":{"id":"https://openalex.org/S4306401569","display_name":"eCite Digital Repository (University of Tasmania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129801699","host_organization_name":"University of Tasmania","host_organization_lineage":["https://openalex.org/I129801699"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Refereed Article"},{"id":"pmh:oai:figshare.com:article/22831160","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Reduction_of_pulmonary_toxicity_by_prednisolone_prophylaxis_during_all-trans_retinoic_acid_treatment_of_acute_promyelocytic_leukemia/22831160","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"mag:328964562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7769839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7033739447","https://openalex.org/W2461757933","https://openalex.org/W2409805922","https://openalex.org/W2166881161","https://openalex.org/W2032427904","https://openalex.org/W2094319709","https://openalex.org/W1948143034","https://openalex.org/W1585061487","https://openalex.org/W2025706554","https://openalex.org/W2036321453"],"abstract_inverted_index":{"All-trans":[0],"retinoic":[1],"acid":[2],"(ATRA)":[3],"induces":[4],"complete":[5],"remission":[6],"(CR)":[7],"in":[8,26,32,58,76,93,97,114,124,145,159,165,172,182,199,205,217],"most":[9],"cases":[10],"of":[11,29,35,47,121,139,174,196,214,220],"acute":[12],"promyelocytic":[13],"leukemia":[14],"(APL)":[15],"but":[16],"its":[17],"use":[18],"is":[19],"associated":[20],"with":[21,79,167,191,203],"potentially":[22],"fatal":[23],"pulmonary":[24,53,140,197],"toxicity":[25,54,141,157,198],"approximately":[27],"25%":[28],"APL":[30,218],"patients":[31,78,96,117,129,161],"the":[33,99,119,125,183,221],"setting":[34],"a":[36,59,143],"rapidly":[37],"rising":[38],"peripheral":[39],"blood":[40],"white":[41],"cell":[42],"count":[43],"(WBC).":[44],"The":[45,193],"efficacy":[46],"oral":[48],"corticosteroid":[49],"for":[50],"prophylaxis":[51,211],"against":[52],"has":[55],"been":[56],"investigated":[57],"prospective":[60],"multi-center":[61],"study.":[62],"ATRA":[63,113,132,164,215],"was":[64,91,110],"administered":[65],"at":[66],"45":[67],"mg/m2/day":[68],"as":[69,150,152],"single":[70],"agent":[71],"therapy":[72,216],"throughout":[73],"induction":[74],"treatment":[75],"19":[77,128],"an":[80,168],"initial":[81],"WBC":[82,100,146,173],"<":[83],"10":[84,103],"x":[85,104,154,176,180],"10(9)/l,":[86],"and":[87,178],"prednisolone":[88,109,210],"75":[89],"mg/day":[90],"added":[92,111],"those":[94],"12":[95],"whom":[98],"rose":[101],"above":[102],"10(9)/l.":[105,155],"Combination":[106],"chemotherapy":[107,134],"plus":[108],"to":[112,147],"six":[115],"other":[116],"on":[118,163],"basis":[120],"criteria":[122],"specified":[123],"protocol.":[126],"All":[127],"who":[130],"received":[131],"without":[133,137],"achieved":[135],"CR":[136],"signs":[138],"despite":[142],"rise":[144],"peak":[148,222],"values":[149],"high":[151],"112":[153],"Pulmonary":[156],"developed":[158],"two":[160],"commenced":[162],"association":[166],"unusually":[169],"rapid":[170],"increment":[171],"7.5":[175],"10(9)/l":[177,181],"32.5":[179],"first":[184],"2":[185],"days;":[186],"both":[187],"were":[188],"subsequently":[189],"treated":[190],"chemotherapy.":[192],"low":[194],"incidence":[195],"this":[200],"study":[201],"compared":[202],"that":[204,209],"previous":[206],"trials":[207],"suggests":[208],"increases":[212],"safety":[213],"irrespective":[219],"WBC.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}