{"id":"https://openalex.org/W32866273","doi":null,"title":"Effect of anterior nucleus of thalamus stimulation on glucose metabolism in hippocampus of epileptic rats.","display_name":"Effect of anterior nucleus of thalamus stimulation on glucose metabolism in hippocampus of epileptic rats.","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W32866273","mag":"32866273","pmid":"https://pubmed.ncbi.nlm.nih.gov/22932185"},"language":"en","primary_location":{"id":"pmid:22932185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22932185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078590331","display_name":"Huanguang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan-Guang Liu","raw_affiliation_strings":["Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051255797","display_name":"Anchao Yang","orcid":"https://orcid.org/0000-0001-9179-5571","observed_orcids":["https://orcid.org/0000-0001-9179-5571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"An-Chao Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086722345","display_name":"Dawei Meng","orcid":"https://orcid.org/0000-0002-3529-3873","observed_orcids":["https://orcid.org/0000-0002-3529-3873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Da-Wei Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324060","display_name":"Kai Zhang","orcid":"https://orcid.org/0000-0003-4237-3115","observed_orcids":["https://orcid.org/0000-0003-4237-3115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100461787","display_name":"Jianguo Zhang","orcid":"https://orcid.org/0000-0002-0009-0574","observed_orcids":["https://orcid.org/0000-0002-0009-0574"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Guo Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9969,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73872109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"125","issue":"17","first_page":"3081","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6000000238418579},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9229999780654907},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lactate-pyruvate-ratio","display_name":"lactate/pyruvate ratio","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.8450000286102295},{"id":"https://openalex.org/keywords/kainic-acid-induced-seizures","display_name":"kainic acid-induced seizures","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ca3-region","display_name":"CA3 region","score":0.6209999918937683},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.8991842269897461},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.8568964004516602},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6531819701194763},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6516664028167725},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6194825172424316},{"id":"https://openalex.org/C2776108384","wikidata":"https://www.wikidata.org/wiki/Q390239","display_name":"Kainic acid","level":4,"score":0.5034491419792175},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.49126023054122925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39931949973106384},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38949325680732727},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.38613370060920715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25412899255752563},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.18408286571502686},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.17325827479362488},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0730532705783844}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020643","descriptor_name":"Anterior Thalamic Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22932185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22932185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:32866273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22932185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994753075","https://openalex.org/W2095143979","https://openalex.org/W2141469601","https://openalex.org/W2127126508","https://openalex.org/W3028686437","https://openalex.org/W1984471283","https://openalex.org/W1995296893","https://openalex.org/W1047663113","https://openalex.org/W4308367582","https://openalex.org/W7037598053"],"abstract_inverted_index":{"BACKGROUND:":[0],"Electrical":[1,180],"stimulation":[2,28,43,51,88,97,115,181,198],"of":[3,7,29,37,62,107,119,138,144,168,182,196,231,249],"the":[4,8,85,95,104,108,114,166,191,197,208,212,223,228,247],"anterior":[5],"nucleus":[6],"thalamus":[9],"(ANT)":[10],"appears":[11],"to":[12],"be":[13],"effective":[14],"against":[15],"seizures.":[16],"In":[17],"this":[18],"study,":[19],"we":[20],"investigated":[21],"changes":[22],"in":[23,31,84,91,113,124,151,165,186,190,211,227],"glucose":[24,169,209],"metabolism":[25,210],"during":[26,234],"high-frequency":[27],"ANT":[30,183,236],"epileptic":[32,145,232],"rats.":[33],"METHODS:":[34],"Three":[35],"groups":[36,176],"rats":[38,146,153,233],"were":[39,80,101,127,147],"used:":[40],"(1)":[41],"a":[42,49,68],"group":[44,52,70,93,199],"(n":[45,53,71],"=":[46,54,72,155,158],"12),":[47],"(2)":[48],"sham":[50,75,96],"12)":[55,73],"with":[56,74],"seizures":[57],"induced":[58,184],"by":[59,129],"stereotactic":[60],"administration":[61],"kainic":[63],"acid":[64],"(KA),":[65],"and":[66,122,140,170,188],"(3)":[67],"control":[69,152],"surgery.":[76],"Concentric":[77],"bipolar":[78],"electrodes":[79],"stereotaxically":[81],"implanted":[82],"unilaterally":[83,110],"ANT.":[86],"High-frequency":[87],"was":[89,172,225],"performed":[90],"each":[92],"except":[94],"group.":[98,116],"Microdialysis":[99],"probes":[100],"lowered":[102],"into":[103],"CA3":[105],"region":[106],"hippocampus":[109,193,214,230],"but":[111,203],"bilaterally":[112],"The":[117,135],"concentrations":[118,137],"glucose,":[120],"lactate,":[121],"pyruvate":[123,171],"dialysate":[125],"samples":[126],"determined":[128],"an":[130],"ISCUS":[131],"microdialysis":[132],"analyzer.":[133],"RESULTS:":[134],"extracellular":[136],"lactate":[139,187],"lactate/pyruvate":[141],"ratio":[142],"(LPR)":[143],"significantly":[148],"higher":[149],"than":[150],"(P":[154,177,200,215],"0.020,":[156],"P":[157],"0.001;":[159],"respectively).":[160],"However,":[161],"no":[162],"significant":[163],"difference":[164],"concentration":[167],"found":[173],"between":[174],"these":[175],">":[178,216],"0.05).":[179,217],"decreases":[185],"LPR":[189],"ipsilateral":[192,229],"(KA":[194],"injected)":[195],"<":[201],"0.05),":[202],"it":[204],"did":[205],"not":[206],"influence":[207],"contralateral":[213],"CONCLUSIONS:":[218],"This":[219],"study":[220],"demonstrated":[221],"that":[222],"glycolysis":[224],"inhibited":[226],"electrical":[235],"stimulation.":[237,252],"These":[238],"findings":[239],"may":[240],"provide":[241],"useful":[242],"information":[243],"for":[244],"better":[245],"understanding":[246],"mechanism":[248],"ANT-deep":[250],"brain":[251]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}