{"id":"https://openalex.org/W32860048","doi":"https://doi.org/10.1093/joneph/23.s15.s41","title":"Functional changes in the aging kidney","display_name":"Functional changes in the aging kidney","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W32860048","doi":"https://doi.org/10.1093/joneph/23.s15.s41","mag":"32860048","pmid":"https://pubmed.ncbi.nlm.nih.gov/20872370"},"language":"en","primary_location":{"id":"doi:10.1093/joneph/23.s15.s41","doi":"https://doi.org/10.1093/joneph/23.s15.s41","is_oa":false,"landing_page_url":"https://doi.org/10.1093/joneph/23.s15.s41","pdf_url":null,"source":{"id":"https://openalex.org/S201014839","display_name":"Journal of Nephrology","issn_l":"1121-8428","issn":["1121-8428","1724-6059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nephrology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W32860048"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082784544","display_name":"Ciro Esposito","orcid":"https://orcid.org/0000-0002-7906-1097","observed_orcids":["https://orcid.org/0000-0002-7906-1097"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Ciro Esposito","raw_affiliation_strings":["Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia - Italy","Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy. espositociro56@live.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia - Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy. espositociro56@live.it","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056247519","display_name":"Antonio Dal Canton","orcid":"https://orcid.org/0000-0002-2189-6315","observed_orcids":["https://orcid.org/0000-0002-2189-6315"]},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]},{"id":"https://openalex.org/I4210151645","display_name":"Policlinico San Matteo Fondazione","ror":"https://ror.org/05w1q1c88","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210151645","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Dal Canton","raw_affiliation_strings":["Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia - Italy","IRCCS Fondazione Policlinico San Matteo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia - Italy","institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"]},{"raw_affiliation_string":"IRCCS Fondazione Policlinico San Matteo","institution_ids":["https://openalex.org/I4210151645"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082784544"],"corresponding_institution_ids":["https://openalex.org/I25217355","https://openalex.org/I4210151645"],"apc_list":{"value":4337,"currency":"USD","value_usd":4337},"apc_paid":null,"fwci":1.7156,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.83543796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"23","issue":"S15","first_page":"S41","last_page":"S45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-aging","display_name":"kidney aging","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glomerular-hemodynamics","display_name":"glomerular hemodynamics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/renal-sodium-handling","display_name":"renal sodium handling","score":0.8709999918937683},{"id":"https://openalex.org/keywords/renal-potassium-handling","display_name":"renal potassium handling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/renal-concentrating-ability","display_name":"renal concentrating ability","score":0.8149999976158142},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.722000002861023},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8999999761581421},{"id":"https://openalex.org/keywords/healthy-older-adults","display_name":"healthy older adults","score":0.6110000014305115},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9351222515106201},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.6558493375778198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6066277027130127},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.5996694564819336},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5793929696083069},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5516893267631531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4904174506664276},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.42867758870124817},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37386780977249146},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36938637495040894},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3598150312900543}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007678","descriptor_name":"Kidney Glomerulus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012079","descriptor_name":"Renal Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/joneph/23.s15.s41","doi":"https://doi.org/10.1093/joneph/23.s15.s41","is_oa":false,"landing_page_url":"https://doi.org/10.1093/joneph/23.s15.s41","pdf_url":null,"source":{"id":"https://openalex.org/S201014839","display_name":"Journal of Nephrology","issn_l":"1121-8428","issn":["1121-8428","1724-6059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nephrology","raw_type":"journal-article"},{"id":"pmid:20872370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20872370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nephrology","raw_type":"Journal Article"},{"id":"mag:32860048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20872370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992738275","https://openalex.org/W2011668507","https://openalex.org/W66851497","https://openalex.org/W2588367776","https://openalex.org/W3153057095","https://openalex.org/W2082078726","https://openalex.org/W2142109912","https://openalex.org/W2120108153","https://openalex.org/W9577891","https://openalex.org/W3953308"],"abstract_inverted_index":{"The":[0],"aging":[1,44,83],"process":[2],"results":[3],"in":[4,7,88],"remarkable":[5],"changes":[6,11,84,96],"the":[8,21,24,28,37,40,66],"kidney.":[9],"These":[10],"are":[12,85],"both":[13],"anatomical":[14],"and":[15,17,55,111,115,118,120],"functional":[16],"have":[18],"been":[19],"considered":[20],"cause":[22],"of":[23,27,39,68],"increased":[25],"propensity":[26],"elderly":[29,47],"to":[30,76,99],"acute":[31],"or":[32,73],"chronic":[33],"renal":[34,63,71,78,95,113],"failure.":[35],"However,":[36],"majority":[38],"early":[41],"studies":[42],"on":[43,108,112],"enrolled":[45],"institutionalized":[46],"patients":[48],"with":[49],"several":[50],"comorbidities":[51],"such":[52],"as":[53],"hypertension":[54],"heart":[56],"disease":[57,72],"which":[58],"could":[59],"by":[60],"themselves":[61],"induce":[62],"alterations.":[64],"Recently":[65],"selection":[67],"subjects":[69],"lacking":[70],"processes":[74],"known":[75],"affect":[77],"function":[79],"has":[80],"demonstrated":[81],"that":[82],"less":[86],"pronounced":[87],"healthy":[89],"aged":[90],"subjects.":[91],"Nonetheless,":[92],"understanding":[93],"aging-induced":[94],"may":[97],"help":[98],"prevent":[100],"life-threatening":[101],"kidney":[102],"disease.":[103],"This":[104],"review":[105],"will":[106],"focus":[107],"glomerular":[109],"hemodynamics,":[110],"sodium":[114],"potassium":[116],"handling":[117],"diluting":[119],"concentrating":[121],"ability.":[122]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
